| Combined inhibition of DYRK1A, SMAD, and trithorax pathways synergizes to induce robust replication in adult human beta cells P Wang, E Karakose, H Liu, E Swartz, C Ackeifi, V Zlatanic, J Wilson, ... Cell metabolism 29 (3), 638-652. e5, 2019 | 161 | 2019 |
| GLP-1 receptor agonists synergize with DYRK1A inhibitors to potentiate functional human β cell regeneration C Ackeifi, P Wang, E Karakose, JE Manning Fox, BJ González, H Liu, ... Science translational medicine 12 (530), eaaw9996, 2020 | 122 | 2020 |
| The kindlins at a glance E Karaköse, HB Schiller, R Fässler Journal of cell science 123 (14), 2353-2356, 2010 | 99 | 2010 |
| Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas H Wang, A Bender, P Wang, E Karakose, WB Inabnet, SK Libutti, A Arnold, ... Nature communications 8 (1), 767, 2017 | 98 | 2017 |
| Pharmacologic and genetic approaches define human pancreatic β cell mitogenic targets of DYRK1A inhibitors C Ackeifi, E Swartz, K Kumar, H Liu, S Chalada, E Karakose, DK Scott, ... JCI insight 5 (1), 2020 | 58 | 2020 |
| Human beta cell regenerative drug therapy for diabetes: past achievements and future challenges P Wang, E Karakose, L Choleva, K Kumar, RJ DeVita, A Garcia-Ocaña, ... Frontiers in Endocrinology 12, 671946, 2021 | 51 | 2021 |
| Glucose-dependent partitioning of arginine to the urea cycle protects β-cells from inflammation A Fu, JC Alvarez-Perez, D Avizonis, T Kin, SB Ficarro, DW Choi, ... Nature metabolism 2 (5), 432-446, 2020 | 46 | 2020 |
| Epigenetic modulation of β cells by interferon-α via PNPT1/mir-26a/TET2 triggers autoimmune diabetes M Stefan-Lifshitz, E Karakose, L Cui, A Ettela, Z Yi, W Zhang, Y Tomer JCI insight 4 (5), 2019 | 38 | 2019 |
| Advances in drug discovery for human beta cell regeneration E Karakose, C Ackeifi, P Wang, AF Stewart Diabetologia 61, 1693-1699, 2018 | 37 | 2018 |
| PINCH-1 promotes Bcl-2-dependent survival signalling and inhibits JNK-mediated apoptosis in the primitive endoderm E Montanez, E Karaköse, D Tischner, A Villunger, R Fässler Journal of Cell Science 125 (21), 5233-5240, 2012 | 34 | 2012 |
| Disrupting the DREAM complex enables proliferation of adult human pancreatic β cells P Wang, E Karakose, C Argmann, H Wang, M Balev, RI Brody, HG Rivas, ... The Journal of clinical investigation 132 (15), 2022 | 33 | 2022 |
| The focal adhesion protein PINCH-1 associates with EPLIN at integrin adhesion sites E Karaköse, T Geiger, K Flynn, K Lorenz-Baath, R Zent, M Mann, ... Journal of cell science 128 (5), 1023-1033, 2015 | 32 | 2015 |
| Crosslinking proteins modulate the self-organization of driven systems V Schaller, KM Schmoller, E Karaköse, B Hammerich, M Maier, ... Soft Matter 9 (30), 7229-7233, 2013 | 27 | 2013 |
| Maladaptive positive feedback production of ChREBPβ underlies glucotoxic β-cell failure LS Katz, G Brill, P Zhang, A Kumar, S Baumel-Alterzon, LB Honig, ... nature communications 13 (1), 4423, 2022 | 15 | 2022 |
| Aberrant methylation underlies insulin gene expression in human insulinoma E Karakose, H Wang, W Inabnet, RV Thakker, S Libutti, ... Nature communications 11 (1), 5210, 2020 | 10 | 2020 |
| Pharmacologic and genetic approaches define human pancreatic β cell mitogenic targets of DYRK1A inhibitors. JCI Insight, 5 (1) C Ackeifi, E Swartz, K Kumar, H Liu, S Chalada, E Karakose, DK Scott, ... | 5 | 2020 |
| GLP-1 receptor agonists synergize with DYRK1A inhibitors to potentiate functional human cell regeneration C Ackeifi, P Wang, E Karakose, JEM Fox, BJ González, H Liu, J Wilson, ... Sci. Transl. Med 12, 2020 | 4 | 2020 |
| 349-OR: Selected DYRK1A Inhibitors Simultaneously Drive Both Human Beta-Cell Proliferation and Differentiation P WANG, K KUMAR, H LIU, O WOOD, E KARAKOSE, L CHOLEVA, ... Diabetes 72 (Supplement_1), 2023 | 3 | 2023 |
| Structure-Function Analysis of p57KIP2 in the Human Pancreatic Beta Cell Reveals a Bipartite Nuclear Localization Signal L Choleva, P Wang, H Liu, O Wood, L Lambertini, DK Scott, E Karakose, ... Endocrinology 165 (2), bqad197, 2024 | 2 | 2024 |
| Human Pancreatic α-Cell Heterogeneity and Trajectory Inference Analysis Using Integrated Single Cell-and Single Nucleus-RNA Sequencing Platforms RB Kang, J Lee, M Varela, Y Li, C Rosselot, T Zhang, E Karakose, ... bioRxiv, 2023.11. 19.567715, 2023 | 2 | 2023 |
