| Ancestral sequence reconstruction for protein engineers MA Spence, JA Kaczmarski, JW Saunders, CJ Jackson Current opinion in structural biology 69, 131-141, 2021 | 111 | 2021 |
| Protein engineering: the potential of remote mutations M Wilding, N Hong, M Spence, AM Buckle, CJ Jackson Biochemical Society Transactions 47 (2), 701-711, 2019 | 84 | 2019 |
| Immunizations with diverse sarbecovirus receptor-binding domains elicit SARS-CoV-2 neutralizing antibodies against a conserved site of vulnerability DL Burnett, KJL Jackson, DB Langley, A Aggarwal, AO Stella, ... Immunity 54 (12), 2908-2921. e6, 2021 | 55 | 2021 |
| A comprehensive phylogenetic analysis of the serpin superfamily MA Spence, MD Mortimer, AM Buckle, BQ Minh, CJ Jackson Molecular Biology and Evolution 38 (7), 2915-2929, 2021 | 55 | 2021 |
| Ancestral Sequence Reconstruction Identifies Structural Changes Underlying the Evolution of Ideonella sakaiensis PETase and Variants with Improved Stability … Y Joho, V Vongsouthi, MA Spence, J Ton, C Gomez, LL Tan, ... Biochemistry 62 (2), 437-450, 2022 | 48 | 2022 |
| Structural and evolutionary approaches to the design and optimization of fluorescence-based small molecule biosensors JA Kaczmarski, JA Mitchell, MA Spence, V Vongsouthi, CJ Jackson Current Opinion in Structural Biology 57, 31-38, 2019 | 32 | 2019 |
| Strategies for increasing protein stability PG Chandler, SS Broendum, BT Riley, MA Spence, CJ Jackson, ... Protein Nanotechnology: Protocols, Instrumentation, and Applications, 163-181, 2020 | 27 | 2020 |
| Comprehensive phylogenetic analysis of the ribonucleotide reductase family reveals an ancestral clade AA Burnim, MA Spence, D Xu, CJ Jackson, N Ando Elife 11, e79790, 2022 | 20 | 2022 |
| A broad-spectrum macrocyclic peptide inhibitor of the SARS-CoV-2 spike protein V Thijssen, DL Hurdiss, OJ Debski-Antoniak, MA Spence, C Franck, ... Proceedings of the National Academy of Sciences 120 (26), e2303292120, 2023 | 17 | 2023 |
| Analysis of insertions and extensions in the functional evolution of the ribonucleotide reductase family AA Burnim, D Xu, MA Spence, CJ Jackson, N Ando Protein Science 31 (12), e4483, 2022 | 10 | 2022 |
| Rugged fitness landscapes minimize promiscuity in the evolution of transcriptional repressors AT Meger, MA Spence, M Sandhu, D Matthews, J Chen, CJ Jackson, ... Cell Systems 15 (4), 374-387. e6, 2024 | 7 | 2024 |
| Leveraging ancestral sequence reconstruction for protein representation learning DS Matthews, MA Spence, AC Mater, J Nichols, SB Pulsford, M Sandhu, ... Nature Machine Intelligence 6 (12), 1542-1555, 2024 | 4 | 2024 |
| Increasing the Soluble Expression and Whole-Cell Activity of the Plastic-Degrading Enzyme MHETase through Consensus Design JW Saunders, AM Damry, V Vongsouthi, MA Spence, RL Frkic, C Gomez, ... Biochemistry, 2024 | 3 | 2024 |
| Ancestral reconstruction of polyethylene terephthalate degrading cutinases reveals a rugged and unexplored sequence-fitness landscape V Vongsouthi, R Georgelin, D Matthews, J Saunders, BM Lee, J Ton, ... bioRxiv, 2024.04. 25.591214, 2024 | 3 | 2024 |
| Evo-velocity: Protein language modeling accelerates the study of evolution M Sandhu, MA Spence, CJ Jackson Cell Systems 13 (4), 271-273, 2022 | 2 | 2022 |
| Protein Evolution as a Complex System B Gall, SB Pulsford, D Matthews, MA Spence, JA Kaczmarski, JZ Chen, ... arXiv preprint arXiv:2412.06115, 2024 | | 2024 |
| Computational and Experimental Exploration of Protein Fitness Landscapes: Navigating Smooth and Rugged Terrains M Sandhu, J Chen, D Matthews, MA Spence, SB Pulsford, B Gall, ... arXiv preprint arXiv:2411.12957, 2024 | | 2024 |
| Enzymes and Uses Thereof CJ Jackson, V Vongsouthi, M Spence US Patent App. 18/578,768, 2024 | | 2024 |
| Enzyme variants and uses thereof JW Saunders, M Spence, V Vongsouthi, AM Damry, CJ Jackson US Patent App. 18/507,504, 2024 | | 2024 |
| The rugged DNA-binding sequence-fitness landscape of the LacI/GalR Family is a product of asymmetry in the operator: repressor complex AT Meger, MA Spence, M Sandhu, CJ Jackson, S Raman bioRxiv, 2022.10. 25.513693, 2022 | | 2022 |
