| On the role of helper lipids in lipid nanoparticle formulations of siRNA JA Kulkarni, D Witzigmann, J Leung, YYC Tam, PR Cullis Nanoscale 11 (45), 21733-21739, 2019 | 316 | 2019 |
| Lipid nanoparticle technology for therapeutic gene regulation in the liver D Witzigmann, JA Kulkarni, J Leung, S Chen, PR Cullis, R van der Meel Advanced drug delivery reviews 159, 344-363, 2020 | 311 | 2020 |
| Fibrin is a critical regulator of neutrophil effector function at the oral mucosal barrier LM Silva, AD Doyle, T Greenwell-Wild, N Dutzan, CL Tran, L Abusleme, ... Science 374 (6575), eabl5450, 2021 | 133 | 2021 |
| Fusion-dependent formation of lipid nanoparticles containing macromolecular payloads JA Kulkarni, D Witzigmann, J Leung, R van der Meel, J Zaifman, ... Nanoscale 11 (18), 9023-9031, 2019 | 127 | 2019 |
| Induction of bleb structures in lipid nanoparticle formulations of mRNA leads to improved transfection potency MHY Cheng, J Leung, Y Zhang, C Strong, G Basha, A Momeni, Y Chen, ... Advanced Materials 35 (31), 2303370, 2023 | 96 | 2023 |
| Spontaneous, solvent-free entrapment of siRNA within lipid nanoparticles JA Kulkarni, SB Thomson, J Zaifman, J Leung, PK Wagner, A Hill, ... Nanoscale 12 (47), 23959-23966, 2020 | 51 | 2020 |
| Simultaneous, single-particle measurements of size and loading give insights into the structure of drug-delivery nanoparticles A Kamanzi, Y Gu, R Tahvildari, Z Friedenberger, X Zhu, R Berti, ... ACS nano 15 (12), 19244-19255, 2021 | 38 | 2021 |
| Aortic intimal resident macrophages are essential for maintenance of the non-thrombogenic intravascular state GE Hernandez, F Ma, G Martinez, NB Firozabadi, J Salvador, LJ Juang, ... Nature cardiovascular research 1 (1), 67-84, 2022 | 32 | 2022 |
| Sustained depletion of FXIII-A by inducing acquired FXIII-B deficiency AW Strilchuk, SC Meixner, J Leung, NS Safikhan, JA Kulkarni, HM Russell, ... Blood, The Journal of the American Society of Hematology 136 (25), 2946-2954, 2020 | 28 | 2020 |
| Hypofibrinogenemia with preserved hemostasis and protection from thrombosis in mice with an Fga truncation mutation WS Hur, DS Paul, EG Bouck, OA Negrón, JM Mwiza, LG Poole, ... Blood, The Journal of the American Society of Hematology 139 (9), 1374-1388, 2022 | 26 | 2022 |
| Suppression of fibrin (ogen)-driven pathologies in disease models through controlled knockdown by lipid nanoparticle delivery of siRNA LJ Juang, WS Hur, LM Silva, AW Strilchuk, B Francisco, J Leung, ... Blood, The Journal of the American Society of Hematology 139 (9), 1302-1311, 2022 | 22 | 2022 |
| Lipid Nanoparticle-Mediated Hit-and-Run Approaches Yield Efficient and Safe In Situ Gene Editing in Human Skin J Bolsoni, D Liu, F Mohabatpour, R Ebner, G Sadhnani, B Tafech, J Leung, ... ACS nano 17 (21), 22046-22059, 2023 | 15 | 2023 |
| Elimination of fibrin polymer formation or crosslinking, but not fibrinogen deficiency, is protective against diet‐induced obesity and associated pathologies WS Hur, KC King, YN Patel, YV Nguyen, Z Wei, Y Yang, LJ Juang, ... Journal of Thrombosis and Haemostasis 20 (12), 2873-2886, 2022 | 14 | 2022 |
| Genetically engineered transfusable platelets using mRNA lipid nanoparticles J Leung, C Strong, KE Badior, M Robertson, X Wu, MA Meledeo, E Kang, ... Science advances 9 (48), eadi0508, 2023 | 10 | 2023 |
| Exploring Mechanisms of Lipid Nanoparticle‐Mucus Interactions in Healthy and Cystic Fibrosis Conditions B Tafech, MR Rokhforouz, J Leung, MMH Sung, PJC Lin, DD Sin, ... Advanced Healthcare Materials, 2304525, 2024 | 8 | 2024 |
| Lipid nanoparticles and siRNA targeting plasminogen provide lasting inhibition of fibrinolysis in mouse and dog models of hemophilia A AW Strilchuk, WS Hur, P Batty, Y Sang, SR Abrahams, ASM Yong, ... Science Translational Medicine 16 (735), eadh0027, 2024 | 6 | 2024 |
| Emerging gene therapies for enhancing the hemostatic potential of platelets J Leung, MF Cau, CJ Kastrup Transfusion 61, S275-S285, 2021 | 3 | 2021 |
| Platelets Genetically Modified with mRNA-Lipid Nanoparticles Are Functionally Similar to Clinically Transfused Platelets in Vitro C Strong, J Leung, K Badior, M Robertson, E Kang, LJ Juang, P Cullis, ... 2022 Annual Meeting, 2022 | 2 | 2022 |
| Genetic engineering of transfusable platelets with mRNA-lipid nanoparticles is compatible with blood banking practices C Strong, J Leung, E Kang, KE Badior, M Robertson, N Pereyra, ... Blood 144 (21), 2223-2236, 2024 | 1 | 2024 |
| RNA Therapeutics to Control Fibrinolysis: Review on Applications in Biology and Medicine F Ferraresso, J Leung, CJ Kastrup Journal of Thrombosis and Haemostasis, 2024 | 1 | 2024 |
Pieter R CullisProfessor Biochemistry, University of BCVerified email at mail.ubc.ca