| Detecting the mutational signature of homologous recombination deficiency in clinical samples DC Gulhan, JJK Lee, GEM Melloni, I Cortes-Ciriano, PJ Park Nature genetics 51 (5), 912-919, 2019 | 275 | 2019 |
| Association of apolipoprotein B–containing lipoproteins and risk of myocardial infarction in individuals with and without atherosclerosis: distinguishing between particle … NA Marston, RP Giugliano, GEM Melloni, JG Park, V Morrill, MA Blazing, ... JAMA cardiology 7 (3), 250-256, 2022 | 192 | 2022 |
| The origins and genetic interactions of KRAS mutations are allele- and tissue-specific JH Cook, GEM Melloni, DC Gulhan, PJ Park, KM Haigis Nature communications 12 (1), 1808, 2021 | 160 | 2021 |
| Genetic drivers of heterogeneity in type 2 diabetes pathophysiology K Suzuki, K Hatzikotoulas, L Southam, HJ Taylor, X Yin, KM Lorenz, ... Nature 627 (8003), 347-357, 2024 | 124 | 2024 |
| Release of paused RNA polymerase II at specific loci favors DNA double-strand-break formation and promotes cancer translocations GI Dellino, F Palluzzi, AM Chiariello, R Piccioni, S Bianco, L Furia, ... Nature genetics 51 (6), 1011-1023, 2019 | 105 | 2019 |
| The effect of PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibition on the risk of venous thromboembolism NA Marston, Y Gurmu, GEM Melloni, M Bonaca, B Gencer, PS Sever, ... Circulation 141 (20), 1600-1607, 2020 | 93 | 2020 |
| Computational analysis of cancer genome sequencing data I Cortés-Ciriano, DC Gulhan, JJK Lee, GEM Melloni, PJ Park Nature Reviews Genetics 23 (5), 298-314, 2022 | 88 | 2022 |
| Very low-depth whole-genome sequencing in complex trait association studies A Gilly, L Southam, D Suveges, K Kuchenbaecker, R Moore, GEM Melloni, ... Bioinformatics 35 (15), 2555-2561, 2019 | 88 | 2019 |
| INSPEcT: a computational tool to infer mRNA synthesis, processing and degradation dynamics from RNA-and 4sU-seq time course experiments S De Pretis, T Kress, MJ Morelli, GEM Melloni, L Riva, B Amati, ... Bioinformatics 31 (17), 2829-2835, 2015 | 77 | 2015 |
| p53 loss in breast cancer leads to Myc activation, increased cell plasticity, and expression of a mitotic signature with prognostic value A Santoro, T Vlachou, L Luzi, G Melloni, L Mazzarella, E D’Elia, X Aobuli, ... Cell reports 26 (3), 624-638. e8, 2019 | 76 | 2019 |
| Predictive utility of a coronary artery disease polygenic risk score in primary prevention NA Marston, JP Pirruccello, GEM Melloni, S Koyama, FK Kamanu, ... JAMA cardiology 8 (2), 130-137, 2023 | 75 | 2023 |
| In Vivo Genetic Screens of Patient-Derived Tumors Revealed Unexpected Frailty of the Transformed Phenotype D Bossi, A Cicalese, GI Dellino, L Luzi, L Riva, C D'Alesio, GR Diaferia, ... Cancer discovery 6 (6), 650-663, 2016 | 70 | 2016 |
| The hidden genomic landscape of acute myeloid leukemia: subclonal structure revealed by undetected mutations M Bodini, C Ronchini, L Giacò, A Russo, GEM Melloni, L Luzi, D Sardella, ... Blood, The Journal of the American Society of Hematology 125 (4), 600-605, 2015 | 68 | 2015 |
| A polygenic risk score predicts atrial fibrillation in cardiovascular disease NA Marston, AC Garfinkel, FK Kamanu, GM Melloni, C Roselli, P Jarolim, ... European Heart Journal 44 (3), 221-231, 2023 | 44 | 2023 |
| Clinical application of a novel genetic risk score for ischemic stroke in patients with cardiometabolic disease NA Marston, PN Patel, FK Kamanu, F Nordio, GM Melloni, C Roselli, ... Circulation 143 (5), 470-478, 2021 | 41 | 2021 |
| The E3 ubiquitin ligase WWP1 sustains the growth of acute myeloid leukaemia AG Sanarico, C Ronchini, A Croce, EM Memmi, UA Cammarata, ... Leukemia 32 (4), 911-919, 2018 | 40 | 2018 |
| DOTS-Finder: a comprehensive tool for assessing driver genes in cancer genomes GEM Melloni, AGE Ogier, S de Pretis, L Mazzarella, M Pelizzola, ... Genome medicine 6, 1-13, 2014 | 40 | 2014 |
| Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits A Gilly, D Suveges, K Kuchenbaecker, M Pollard, L Southam, ... Nature communications 9 (1), 4674, 2018 | 36 | 2018 |
| Lipoprotein (a), C-reactive protein, and cardiovascular risk in primary and secondary prevention populations AM Small, A Pournamdari, GEM Melloni, BM Scirica, DL Bhatt, I Raz, ... JAMA cardiology 9 (4), 385-391, 2024 | 27 | 2024 |
| LowMACA: exploiting protein family analysis for the identification of rare driver mutations in cancer GEM Melloni, S de Pretis, L Riva, M Pelizzola, A Céol, J Costanza, ... BMC bioinformatics 17, 1-12, 2016 | 23 | 2016 |
Marc S. SabatineTIMI Study Group, Brigham and Women's Hospital, Harvard Medical SchoolVerified email at partners.org