| Production of hyperpolarized [1,4-13C2]malate from [1,4-13C2]fumarate is a marker of cell necrosis and treatment response in tumors FA Gallagher, MI Kettunen, DE Hu, PR Jensen, R Zandt, M Karlsson, ... Proceedings of the National Academy of Sciences 106 (47), 19801-19806, 2009 | 380 | 2009 |
| Reporter gene imaging of targeted T cell immunotherapy in recurrent glioma KV Keu, TH Witney, S Yaghoubi, J Rosenberg, A Kurien, R Magnusson, ... Science translational medicine 9 (373), eaag2196, 2017 | 333 | 2017 |
| Kinetic modeling of hyperpolarized 13C label exchange between pyruvate and lactate in tumor cells TH Witney, MI Kettunen, KM Brindle Journal of Biological Chemistry 286 (28), 24572-24580, 2011 | 168 | 2011 |
| Detecting treatment response in a model of human breast adenocarcinoma using hyperpolarised [1-13C] pyruvate and [1, 4-13C2] fumarate TH Witney, MI Kettunen, DE Hu, FA Gallagher, SE Bohndiek, ... British journal of cancer 103 (9), 1400-1406, 2010 | 166 | 2010 |
| Magnetic resonance imaging with hyperpolarized [1, 4-13C2] fumarate allows detection of early renal acute tubular necrosis MR Clatworthy, MI Kettunen, DE Hu, RJ Mathews, TH Witney, ... Proceedings of the National Academy of Sciences 109 (33), 13374-13379, 2012 | 133 | 2012 |
| Magnetization transfer measurements of exchange between hyperpolarized [1‐13C]pyruvate and [1‐13C]lactate in a murine lymphoma MI Kettunen, D Hu, TH Witney, R McLaughlin, FA Gallagher, SE Bohndiek, ... Magnetic Resonance in Medicine: An Official Journal of the International …, 2010 | 133 | 2010 |
| A comparison between radiolabeled fluorodeoxyglucose uptake and hyperpolarized 13C-labeled pyruvate utilization as methods for detecting tumor response to treatment TH Witney, MI Kettunen, SE Day, D Hu, AA Neves, FA Gallagher, ... Neoplasia 11 (6), 574-IN11, 2009 | 130 | 2009 |
| Evaluation of integrin αvβ6 cystine knot PET tracers to detect cancer and idiopathic pulmonary fibrosis RH Kimura, L Wang, B Shen, L Huo, W Tummers, FV Filipp, HH Guo, ... Nature communications 10 (1), 4673, 2019 | 100 | 2019 |
| Detection of Tumor Response to a Vascular Disrupting Agent by Hyperpolarized 13C Magnetic Resonance Spectroscopy SE Bohndiek, MI Kettunen, D Hu, TH Witney, BWC Kennedy, ... Molecular cancer therapeutics 9 (12), 3278-3288, 2010 | 94 | 2010 |
| Imaging of T-cells and their responses during anti-cancer immunotherapy M Krekorian, GO Fruhwirth, M Srinivas, CG Figdor, S Heskamp, TH Witney, ... Theranostics 9 (25), 7924, 2019 | 88 | 2019 |
| Evaluation of Deuterated 18F- and 11C-Labeled Choline Analogs for Cancer Detection by Positron Emission Tomography TH Witney, IS Alam, DR Turton, G Smith, L Carroll, D Brickute, FJ Twyman, ... Clinical Cancer Research 18 (4), 1063-1072, 2012 | 72 | 2012 |
| PET imaging of tumor glycolysis downstream of hexokinase through noninvasive measurement of pyruvate kinase M2 TH Witney, ML James, B Shen, E Chang, C Pohling, N Arksey, A Hoehne, ... Science translational medicine 7 (310), 310ra169-310ra169, 2015 | 69 | 2015 |
| Comparison of the C2A domain of synaptotagmin-I and annexin-V as probes for detecting cell death IS Alam, AA Neves, TH Witney, J Boren, KM Brindle Bioconjugate chemistry 21 (5), 884-891, 2010 | 67 | 2010 |
| A Systematic Comparison of 18F-C-SNAT to Established Radiotracer Imaging Agents for the Detection of Tumor Response to Treatment TH Witney, A Hoehne, RE Reeves, O Ilovich, M Namavari, B Shen, ... Clinical Cancer Research 21 (17), 3896-3905, 2015 | 61 | 2015 |
| Assessment of Tumor Redox Status through (S)-4-(3-[18F]fluoropropyl)-L-Glutamic Acid PET Imaging of System xc− Activity PN McCormick, HE Greenwood, M Glaser, ODK Maddocks, T Gendron, ... Cancer research 79 (4), 853-863, 2022 | 53 | 2022 |
| Imaging tumour cell metabolism using hyperpolarized 13C magnetic resonance spectroscopy TH Witney, KM Brindle Biochemical Society Transactions 38 (5), 1220-1224, 2010 | 49 | 2010 |
| A novel radiotracer to image glycogen metabolism in tumors by positron emission tomography TH Witney, L Carroll, IS Alam, A Chandrashekran, QD Nguyen, R Sala, ... Cancer research 74 (5), 1319-1328, 2014 | 48 | 2014 |
| Measurement of tumor antioxidant capacity and prediction of chemotherapy resistance in preclinical models of ovarian cancer by positron emission tomography HE Greenwood, PN McCormick, T Gendron, M Glaser, R Pereira, ... Clinical Cancer Research 25 (8), 2471-2482, 2019 | 47 | 2019 |
| AshwaMAX and Withaferin A inhibits gliomas in cellular and murine orthotopic models E Chang, C Pohling, A Natarajan, TH Witney, J Kaur, L Xu, ... Journal of neuro-oncology 126, 253-264, 2016 | 43 | 2016 |
| High-throughput PET/CT imaging using a multiple-mouse imaging system HE Greenwood, Z Nyitrai, G Mocsai, S Hobor, TH Witney Journal of Nuclear Medicine 61 (2), 292-297, 2020 | 41 | 2020 |
Prof. K.M. BrindleUniversity of CambridgeVerified email at cam.ac.uk