| Development of “substrate-trapping” mutants to identify physiological substrates of protein tyrosine phosphatases AJ Flint, T Tiganis, D Barford, NK Tonks Proceedings of the National Academy of Sciences 94 (5), 1680-1685, 1997 | 1005 | 1997 |
| Coordinated control of endothelial nitric-oxide synthase phosphorylation by protein kinase C and the cAMP-dependent protein kinase BJ Michell, Z Chen, T Tiganis, D Stapleton, F Katsis, DA Power, AT Sim, ... Journal of biological chemistry 276 (21), 17625-17628, 2001 | 714 | 2001 |
| Reactive oxygen species enhance insulin sensitivity K Loh, H Deng, A Fukushima, X Cai, B Boivin, S Galic, C Bruce, ... Cell metabolism 10 (4), 260-272, 2009 | 681 | 2009 |
| The Akt kinase signals directly to endothelial nitric oxide synthase BJ Michell, JE Griffiths, KI Mitchelhill, I Rodriguez-Crespo, T Tiganis, ... Current biology 9 (15), S1, 1999 | 622 | 1999 |
| Leptin and insulin act on POMC neurons to promote the browning of white fat GT Dodd, S Decherf, K Loh, SE Simonds, F Wiede, E Balland, TL Merry, ... Cell 160 (1), 88-104, 2015 | 440 | 2015 |
| Obesity drives STAT-1-dependent NASH and STAT-3-dependent HCC M Grohmann, F Wiede, GT Dodd, EN Gurzov, GJ Ooi, T Butt, ... Cell 175 (5), 1289-1306. e20, 2018 | 358 | 2018 |
| Protein tyrosine phosphatase function: the substrate perspective T Tiganis, AM Bennett Biochemical Journal 402 (1), 1-15, 2007 | 354 | 2007 |
| Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers CG Fedele, LM Ooms, M Ho, J Vieusseux, SA O'Toole, EK Millar, ... Proceedings of the National Academy of Sciences 107 (51), 22231-22236, 2010 | 334 | 2010 |
| Regulation of insulin signaling through reversible oxidation of the protein-tyrosine phosphatases TC45 and PTP1B TC Meng, DA Buckley, S Galic, T Tiganis, NK Tonks Journal of Biological Chemistry 279 (36), 37716-37725, 2004 | 327 | 2004 |
| Epidermal growth factor promotes MDA-MB-231 breast cancer cell migration through a phosphatidylinositol 3′-kinase and phospholipase C-dependent mechanism JT Price, T Tiganis, A Agarwal, D Djakiew, EW Thompson Cancer research 59 (21), 5475-5478, 1999 | 316 | 1999 |
| Epidermal Growth Factor Receptor and the Adaptor Protein p52Shc Are Specific Substrates of T-Cell Protein Tyrosine Phosphatase T Tiganis, AM Bennett, KS Ravichandran, NK Tonks Molecular and cellular biology 18 (3), 1622-1634, 1998 | 303 | 1998 |
| Reactive oxygen species and insulin resistance: the good, the bad and the ugly T Tiganis Trends in pharmacological sciences 32 (2), 82-89, 2011 | 300 | 2011 |
| Age-related decline in primary CD8+ T cell responses is associated with the development of senescence in virtual memory CD8+ T cells KM Quinn, A Fox, KL Harland, BE Russ, J Li, THO Nguyen, L Loh, ... Cell reports 23 (12), 3512-3524, 2018 | 247 | 2018 |
| Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP S Galic, C Hauser, BB Kahn, FG Haj, BG Neel, NK Tonks, T Tiganis Molecular and cellular biology 25 (2), 819-829, 2005 | 246 | 2005 |
| T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice F Wiede, BJ Shields, SH Chew, K Kyparissoudis, C Van Vliet, S Galic, ... The Journal of clinical investigation 121 (12), 4758-4774, 2011 | 240 | 2011 |
| Regulation of insulin receptor signaling by the protein tyrosine phosphatase TCPTP S Galic, M Klingler-Hoffmann, MT Fodero-Tavoletti, MA Puryer, TC Meng, ... Molecular and cellular biology 23 (6), 2096-2108, 2003 | 223 | 2003 |
| Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance K Loh, A Fukushima, X Zhang, S Galic, D Briggs, PJ Enriori, S Simonds, ... Cell metabolism 14 (5), 684-699, 2011 | 210 | 2011 |
| Selective regulation of tumor necrosis factor–induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase C van Vliet, PE Bukczynska, MA Puryer, CM Sadek, BJ Shields, ... Nature immunology 6 (3), 253-260, 2005 | 207 | 2005 |
| PTP1B and TCPTP–nonredundant phosphatases in insulin signaling and glucose homeostasis T Tiganis The FEBS journal 280 (2), 445-458, 2013 | 199 | 2013 |
| Protein tyrosine phosphatases in hypothalamic insulin and leptin signaling ZY Zhang, GT Dodd, T Tiganis Trends in pharmacological sciences 36 (10), 661-674, 2015 | 190 | 2015 |