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Thomas Sedlak MD, PhD
Thomas Sedlak MD, PhD
Johns Hopkins School of Medicine, Psychiatry and Behavioral Sciences
Verified email at jhmi.edu
Title
Cited by
Cited by
Year
Multiple Bcl-2 family members demonstrate selective dimerizations with Bax.
TW Sedlak, ZN Oltvai, E Yang, K Wang, LH Boise, CB Thompson, ...
Proceedings of the National Academy of Sciences 92 (17), 7834-7838, 1995
11231995
The diverse functions of GAPDH: views from different subcellular compartments
C Tristan, N Shahani, TW Sedlak, A Sawa
Cellular Signalling 23 (2), 317-323, 2011
7502011
Bilirubin and glutathione have complementary antioxidant and cytoprotective roles
TW Sedlak, M Saleh, DS Higginson, BD Paul, KR Juluri, SH Snyder
Proceedings of the National Academy of Sciences 106 (13), 5171-5176, 2009
6192009
Bilirubin benefits: cellular protection by a biliverdin reductase antioxidant cycle
TW Sedlak, SH Snyder
Pediatrics 113 (6), 1776-1782, 2004
5912004
Hematopoietic Malignancies Demonstrate Loss-of-Function Mutations ofBAX
JPP Meijerink, EJBM Mensink, K Wang, TW Sedlak, AW Slöetjes, ...
Blood, The Journal of the American Society of Hematology 91 (8), 2991-2997, 1998
3981998
Oxidative stress and schizophrenia: recent breakthroughs from an old story
FE Emiliani, TW Sedlak, A Sawa
Current Opinion in Psychiatry 27 (3), 185-190, 2014
2092014
Hydrogen sulfide is neuroprotective in Alzheimer’s disease by sulfhydrating GSK3β and inhibiting Tau hyperphosphorylation
D Giovinazzo, B Bursac, JI Sbodio, S Nalluru, T Vignane, AM Snowman, ...
Proceedings of the National Academy of Sciences 118 (4), e2017225118, 2021
1902021
Implications for reactive oxygen species in schizophrenia pathogenesis
M Koga, AV Serritella, A Sawa, TW Sedlak
Schizophrenia Research 176 (1), 52-71, 2016
1702016
Assessing brain metabolism with 7-T proton magnetic resonance spectroscopy in patients with first-episode psychosis
AM Wang, S Pradhan, JM Coughlin, A Trivedi, SL DuBois, JL Crawford, ...
JAMA Psychiatry 76 (3), 314-323, 2019
1602019
The glutathione cycle shapes synaptic glutamate activity
TW Sedlak, BD Paul, GM Parker, LD Hester, AM Snowman, Y Taniguchi, ...
Proceedings of the National Academy of Sciences 116 (7), 2701-2706, 2019
1472019
Constituents of bile, bilirubin and TUDCA, protect against oxidative stress‐induced retinal degeneration
BC Oveson, T Iwase, SF Hackett, SY Lee, S Usui, TW Sedlak, SH Snyder, ...
Journal of Neurochemistry 116 (1), 144-153, 2011
1152011
Cognitive and motivational deficits together with prefrontal oxidative stress in a mouse model for neuropsychiatric illness
AW Johnson, H Jaaro-Peled, N Shahani, TW Sedlak, S Zoubovsky, ...
Proceedings of the National Academy of Sciences 110 (30), 12462-12467, 2013
1122013
Reduction of plasma glutathione in psychosis associated with schizophrenia and bipolar disorder in translational psychiatry
LG Nucifora, T Tanaka, LN Hayes, M Kim, BJ Lee, T Matsuda, ...
Translational Psychiatry 7 (8), e1215-e1215, 2017
1042017
Heme oxygenase-2 is activated by calcium-calmodulin
D Boehning, L Sedaghat, TW Sedlak, SH Snyder
Journal of Biological Chemistry 279 (30), 30927-30930, 2004
1012004
Bilirubin links heme metabolism to neuroprotection by scavenging superoxide
C Vasavda, R Kothari, AP Malla, R Tokhunts, A Lin, M Ji, C Ricco, R Xu, ...
Cell Chemical Biology 26 (10), 1450-1460. e7, 2019
982019
Glutathione is a physiologic reservoir of neuronal glutamate
M Koga, AV Serritella, MM Messmer, A Hayashi-Takagi, LD Hester, ...
Biochemical and Biophysical Research Communications 409 (4), 596-602, 2011
942011
Sulforaphane augments glutathione and influences brain metabolites in human subjects: a clinical pilot study
TW Sedlak, LG Nucifora, M Koga, LS Shaffer, C Higgs, T Tanaka, ...
Molecular Neuropsychiatry 3 (4), 214-222, 2018
792018
DISC1 regulates trafficking and processing of APP and Aβ generation
N Shahani, S Seshadri, H Jaaro-Peled, K Ishizuka, Y Hirota-Tsuyada, ...
Molecular Psychiatry 20 (7), 874-879, 2015
642015
Bax-mediated cell death by the Gax homeoprotein requires mitogen activation but is independent of cell cycle activity
H Perlman, M Sata, A Le Roux, TW Sedlak, D Branellec, K Walsh
EMBO Journal 17 (13), 3576-3586, 1998
631998
Messenger molecules and cell death: therapeutic implications
TW Sedlak, SH Snyder
JAMA 295 (1), 81-89, 2006
592006
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