| The medicinal chemist's toolbox for late stage functionalization of drug-like molecules T Cernak, KD Dykstra, S Tyagarajan, P Vachal, SW Krska Chemical Society Reviews 45 (3), 546-576, 2016 | 1579 | 2016 |
| Profound Methyl Effects in Drug Discovery and a Call for New C H Methylation Reactions H Schönherr, T Cernak Angewandte Chemie International Edition 52 (47), 12256-12267, 2013 | 978 | 2013 |
| Nanomole-scale high-throughput chemistry for the synthesis of complex molecules A Buitrago Santanilla, EL Regalado, T Pereira, M Shevlin, K Bateman, ... Science 347 (6217), 49-53, 2015 | 596 | 2015 |
| Chemistry informer libraries: a chemoinformatics enabled approach to evaluate and advance synthetic methods PS Kutchukian, JF Dropinski, KD Dykstra, B Li, DA DiRocco, ... Chemical science 7 (4), 2604-2613, 2016 | 211 | 2016 |
| Nanoscale synthesis and affinity ranking NJ Gesmundo, B Sauvagnat, PJ Curran, MP Richards, CL Andrews, ... Nature 557 (7704), 228-232, 2018 | 194 | 2018 |
| Mapping the dark space of chemical reactions with extended nanomole synthesis and MALDI-TOF MS S Lin, S Dikler, WD Blincoe, RD Ferguson, RP Sheridan, Z Peng, ... Science 361 (6402), eaar6236, 2018 | 179 | 2018 |
| Automation and computer-assisted planning for chemical synthesis Y Shen, JE Borowski, MA Hardy, R Sarpong, AG Doyle, T Cernak Nature Reviews Methods Primers 1 (1), 1-23, 2021 | 162 | 2021 |
| Pharmaceutical diversification via palladium oxidative addition complexes MR Uehling, RP King, SW Krska, T Cernak, SL Buchwald Science 363 (6425), 405-408, 2019 | 153 | 2019 |
| Multicatalytic synthesis of α-pyrrolidinyl ketones via a tandem palladium (II)/indium (III)-catalyzed aminochlorocarbonylation/Friedel− Crafts acylation reaction TA Cernak, TH Lambert Journal of the American Chemical Society 131 (9), 3124-3125, 2009 | 138 | 2009 |
| A map of the amine–carboxylic acid coupling system B Mahjour, Y Shen, W Liu, T Cernak Nature 580 (7801), 71-75, 2020 | 99 | 2020 |
| Microscale high-throughput experimentation as an enabling technology in drug discovery: Application in the discovery of (Piperidinyl) pyridinyl-1 H-benzimidazole diacylglycerol … T Cernak, NJ Gesmundo, K Dykstra, Y Yu, Z Wu, ZC Shi, P Vachal, ... Journal of Medicinal Chemistry 60 (9), 3594-3605, 2017 | 91 | 2017 |
| Ultrahigh-throughput experimentation for information-rich chemical synthesis B Mahjour, Y Shen, T Cernak Accounts of Chemical Research 54 (10), 2337-2346, 2021 | 72 | 2021 |
| Ausgeprägte Methyleffekte in der Wirkstoff‐Forschung und der Bedarf an neuen C‐H‐Methylierungsreaktionen H Schönherr, T Cernak Angewandte Chemie 125 (47), 12480-12492, 2013 | 72 | 2013 |
| Stable 5‐Substituted Cyclopentadienes for the Diels–Alder Cycloaddition and their Application to the Synthesis of Palau'amine J Hudon, TA Cernak, JA Ashenhurst, JL Gleason Angewandte Chemie International Edition 47 (46), 8885-8888, 2008 | 65 | 2008 |
| Density functional theory guided design of exo-selective dehydroalanine dienophiles for application toward the synthesis of palau'amine TA Cernak, JL Gleason The Journal of Organic Chemistry 73 (1), 102-110, 2008 | 63 | 2008 |
| Mild and Direct C–H Arylation of Quinoxalin-2 (1H)-ones with Aryldiazonium Salts under Metal-Free Conditions K Yin, R Zhang Synlett 29 (05), 597-602, 2018 | 46 | 2018 |
| Predicting reaction conditions from limited data through active transfer learning E Shim, JA Kammeraad, Z Xu, A Tewari, T Cernak, PM Zimmerman Chemical science 13 (22), 6655-6668, 2022 | 45 | 2022 |
| Rapid planning and analysis of high-throughput experiment arrays for reaction discovery B Mahjour, R Zhang, Y Shen, A McGrath, R Zhao, OG Mohamed, Y Lin, ... Nature Communications 14 (1), 3924, 2023 | 36 | 2023 |
| The Formal Cross‐Coupling of Amines and Carboxylic Acids to Form sp3–sp3 Carbon–Carbon Bonds Z Zhang, T Cernak Angewandte Chemie 133 (52), 27499-27504, 2021 | 35 | 2021 |
| Computer-aided key step generation in alkaloid total synthesis Y Lin, R Zhang, D Wang, T Cernak Science 379 (6631), 453-457, 2023 | 34 | 2023 |