Metabolism and pharmacokinetics of pharmaceuticals in cats (Felix sylvestris catus) and implications for the risk assessment of feed additives and contaminants LS Lautz, MZ Jeddi, F Girolami, C Nebbia, J Dorne Toxicology Letters 338, 114-127, 2021 | 66 | 2021 |
Evaluation of SimpleTreat 4.0: Simulations of pharmaceutical removal in wastewater treatment plant facilities LS Lautz, J Struijs, TM Nolte, AM Breure, E Van der Grinten, ... Chemosphere 168, 870-876, 2017 | 51 | 2017 |
Human variability in isoform-specific UDP-glucuronosyltransferases: markers of acute and chronic exposure, polymorphisms and uncertainty factors EEJ Kasteel, K Darney, NI Kramer, J Dorne, LS Lautz Archives of toxicology 94, 2637-2661, 2020 | 49 | 2020 |
Towards a systematic method for assessing the impact of chemical pollution on ecosystem services of water systems J Wang, LS Lautz, TM Nolte, L Posthuma, KR Koopman, RSEW Leuven, ... Journal of Environmental Management 281, 111873, 2021 | 43 | 2021 |
Ecological risks of imidacloprid to aquatic species in the Netherlands: Measured and estimated concentrations compared to species sensitivity distributions NW Thunnissen, LS Lautz, TWG Van Schaik, AJ Hendriks Chemosphere 254, 126604, 2020 | 43 | 2020 |
An open source physiologically based kinetic model for the chicken (Gallus gallus domesticus): Calibration and validation for the prediction residues in tissues and eggs LS Lautz, C Nebbia, S Hoeks, R Oldenkamp, AJ Hendriks, AMJ Ragas, ... Environment International 136, 105488, 2020 | 40 | 2020 |
Human variability in glutathione-S-transferase activities, tissue distribution and major polymorphic variants: Meta-analysis and implication for chemical risk assessment FM Buratti, K Darney, S Vichi, L Turco, E Di Consiglio, LS Lautz, ... Toxicology letters 337, 78-90, 2021 | 36 | 2021 |
Generic physiologically based kinetic modelling for farm animals: Part I. Data collection of physiological parameters in swine, cattle and sheep LS Lautz, J Dorne, R Oldenkamp, AJ Hendriks, AMJ Ragas Toxicology letters 319, 95-101, 2020 | 36 | 2020 |
Acetylcholinesterase inhibition in electric eel and human donor blood: an in vitro approach to investigate interspecies differences and human variability in toxicodynamics EEJ Kasteel, SM Nijmeijer, K Darney, LS Lautz, JLCM Dorne, NI Kramer, ... Archives of Toxicology 94 (12), 4055-4065, 2020 | 34 | 2020 |
Physiologically based kinetic models for farm animals: Critical review of published models and future perspectives for their use in chemical risk assessment LS Lautz, R Oldenkamp, JL Dorne, AMJ Ragas Toxicology in Vitro 60, 61-70, 2019 | 34 | 2019 |
Human variability in polymorphic CYP2D6 metabolism: Implications for the risk assessment of chemicals in food and emerging designer drugs K Darney, LS Lautz, C Béchaux, W Wiecek, E Testai, B Amzal, J Dorne Environment International 156, 106760, 2021 | 27 | 2021 |
Human variability in influx and efflux transporters in relation to uncertainty factors for chemical risk assessment K Darney, L Turco, FM Buratti, E Di Consiglio, S Vichi, AC Roudot, ... Food and Chemical Toxicology 140, 111305, 2020 | 27 | 2020 |
Bayesian meta-analysis of inter-phenotypic differences in human serum paraoxonase-1 activity for chemical risk assessment K Darney, EEJ Kasteel, FM Buratti, L Turco, S Vichi, C Béchaux, ... Environment international 138, 105609, 2020 | 26 | 2020 |
Modelling human variability in toxicokinetic and toxicodynamic processes using Bayesian meta‐analysis, physiologically‐based modelling and in vitro systems E Testai, C Bechaux, FM Buratti, K Darney, E Di Consiglio, EEJ Kasteel, ... EFSA Supporting Publications 18 (4), 6504E, 2021 | 25 | 2021 |
Risk assessment of chemicals in food and feed: principles, applications and future perspectives L Ingenbleek, LS Lautz, G Dervilly, K Darney, MC Astuto, J Tarazona, ... | 25 | 2020 |
Human variability in carboxylesterases and carboxylesterase-related uncertainty factors for chemical risk assessment E Di Consiglio, K Darney, FM Buratti, L Turco, S Vichi, E Testai, LS Lautz, ... Toxicology Letters 350, 162-170, 2021 | 24 | 2021 |
Generic physiologically based kinetic modelling for farm animals: Part II. Predicting tissue concentrations of chemicals in swine, cattle, and sheep LS Lautz, S Hoeks, R Oldenkamp, AJ Hendriks, J Dorne, AMJ Ragas Toxicology Letters 318, 50-56, 2020 | 24 | 2020 |
OpenCYP: An open source database exploring human variability in activities and frequencies of polymophisms for major cytochrome P-450 isoforms across world populations S Vichi, FM Buratti, E Di Consiglio, L Turco, LS Lautz, K Darney, ... Toxicology Letters 350, 267-282, 2021 | 13 | 2021 |
Application of in vitro data in physiologically-based kinetic models for quantitative in vitro-in vivo extrapolation: A case-study for baclofen EEJ Kasteel, LS Lautz, M Culot, NI Kramer, A Zwartsen Toxicology in Vitro 76, 105223, 2021 | 11 | 2021 |
Fipronil and fipronil sulfone in chicken: From in vitro experiments to in vivo PBK model predictions LS Lautz, G Stoopen, AJ Ginting, R Hoogenboom, A Punt Food and Chemical Toxicology 165, 113086, 2022 | 10 | 2022 |