| MYC drives temporal evolution of small cell lung cancer subtypes by reprogramming neuroendocrine fate AS Ireland, AM Micinski, DW Kastner, B Guo, SJ Wait, KB Spainhower, ... Cancer cell 38 (1), 60-78. e12, 2020 | 380 | 2020 |
| MOFSimplify, machine learning models with extracted stability data of three thousand metal–organic frameworks A Nandy, G Terrones, N Arunachalam, C Duan, DW Kastner, HJ Kulik Scientific Data 9 (1), 74, 2022 | 84 | 2022 |
| Engineering of serine protease for improved thermostability and catalytic activity using rational design NM Ashraf, A Krishnagopal, A Hussain, D Kastner, AMM Sayed, YK Mok, ... International journal of biological macromolecules 126, 229-237, 2019 | 74 | 2019 |
| ASCL1 represses a SOX9+ neural crest stem-like state in small cell lung cancer RR Olsen, AS Ireland, DW Kastner, SM Groves, KB Spainhower, K Pozo, ... Genes & Development 35 (11-12), 847-869, 2021 | 54 | 2021 |
| Using Computational Chemistry to Reveal Nature’s Blueprints for Single-Site Catalysis of C–H Activation A Nandy, H Adamji, DW Kastner, V Vennelakanti, A Nazemi, M Liu, ... ACS Catalysis 12 (15), 9281-9306, 2022 | 36 | 2022 |
| Humanin induces conformational changes in the apoptosis regulator BAX and sequesters it into fibers, preventing mitochondrial outer-membrane permeabilization DL Morris, DW Kastner, S Johnson, MP Strub, Y He, CKE Bleck, DY Lee, ... Journal of Biological Chemistry 294 (50), 19055-19065, 2019 | 35 | 2019 |
| Mechanistic insights into substrate positioning that distinguish non-heme Fe (II)/α-ketoglutarate-dependent halogenases and hydroxylases DW Kastner, A Nandy, R Mehmood, HJ Kulik ACS Catalysis 13 (4), 2489-2501, 2023 | 26 | 2023 |
| Impact of Dehydroamino Acids on the Structure and Stability of Incipient 310-Helical Peptides D Joaquin, MA Lee, DW Kastner, J Singh, ST Morrill, G Damstedt, ... The Journal of organic chemistry 85 (3), 1601-1613, 2019 | 23 | 2019 |
| Bulky dehydroamino acids enhance proteolytic stability and folding in β-hairpin peptides A Jalan, DW Kastner, KGI Webber, MS Smith, JL Price, SL Castle Organic letters 19 (19), 5190-5193, 2017 | 19 | 2017 |
| Probing the mechanism of isonitrile formation by a non-heme iron (II)-dependent oxidase/decarboxylase A Del Rio Flores, DW Kastner, Y Du, M Narayanamoorthy, Y Shen, W Cai, ... Journal of the American Chemical Society 144 (13), 5893-5901, 2022 | 17 | 2022 |
| Emergence of a proton exchange-based isomerization and lactonization mechanism in the plant coumarin synthase COSY CY Kim, AJ Mitchell, DW Kastner, CE Albright, MA Gutierrez, ... Nature Communications 14 (1), 597, 2023 | 16 | 2023 |
| Influence of the greater protein environment on the electrostatic potential in metalloenzyme active sites: The case of formate dehydrogenase A Nazemi, AH Steeves, DW Kastner, HJ Kulik The Journal of Physical Chemistry B 126 (22), 4069-4079, 2022 | 15 | 2022 |
| Active Learning Exploration of Transition-Metal Complexes to Discover Method-Insensitive and Synthetically Accessible Chromophores C Duan, A Nandy, GG Terrones, DW Kastner, HJ Kulik JACS Au 3 (2), 391-401, 2022 | 13 | 2022 |
| Potential involvement of mi-RNA 574-3p in progression of prostate cancer: A bioinformatic study NM Ashraf, K Imran, DW Kastner, K Ikram, A Mushtaq, A Hussain, ... Molecular and cellular probes 36, 21-28, 2017 | 13 | 2017 |
| Enzymatic synthesis of azide by a promiscuous N-nitrosylase A Del Rio Flores, R Zhai, DW Kastner, K Seshadri, S Yang, K De Matias, ... Nature Chemistry, 1-10, 2024 | 4 | 2024 |
| Protein3D: Enabling analysis and extraction of metal‐containing sites from the Protein Data Bank with molSimplify F Edholm, A Nandy, CR Reinhardt, DW Kastner, HJ Kulik Journal of Computational Chemistry 45 (6), 352-361, 2024 | 3 | 2024 |
| Synthesis and evaluation of potent yaku'amide A analogs CCL Lo, D Joaquin, DA Moyá, A Ramos, DW Kastner, SM White, ... Chemical Science 13 (7), 1899-1905, 2022 | 3 | 2022 |
| High-Throughput Discovery of Ferrocene Mechanophores with Enhanced Reactivity and Network Toughening I Kevlishvili, J Vakil, D Kastner, X Huang, S Craig, H Kulik | 1 | 2024 |
| ASCL1 represses a latent osteogenic program in small cell lung Cancer in multiple cells of origin RR Olsen, DW Kastner, AS Ireland, SM Groves, K Pozo, CP Whitney, ... bioRxiv, 2020.11. 11.362632, 2020 | 1 | 2020 |
| IA21 ASCL1 represses a latent osteogenic program in small-cell lung cancer arising from multiple cells of origin RR Olsen, DW Kastner, AS Ireland, K Pozo, CP Whitney, MR Guthrie, ... Journal of Thoracic Oncology 15 (2), S7, 2020 | 1 | 2020 |
Heather J. KulikChemical Engineering and Chemistry, Massachusetts Institute of TechnologyVerified email at mit.edu