| TREM2 regulates microglial cholesterol metabolism upon chronic phagocytic challenge AA Nugent, K Lin, B Van Lengerich, S Lianoglou, L Przybyla, SS Davis, ... Neuron 105 (5), 837-854. e9, 2020 | 510 | 2020 |
| Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice JC Ullman, A Arguello, JA Getz, A Bhalla, CS Mahon, J Wang, T Giese, ... Science Translational Medicine 12 (545), eaay1163, 2020 | 170 | 2020 |
| Human CFEOM1 mutations attenuate KIF21A autoinhibition and cause oculomotor axon stalling L Cheng, J Desai, CJ Miranda, JS Duncan, W Qiu, AA Nugent, AL Kolpak, ... Neuron 82 (2), 334-349, 2014 | 113 | 2014 |
| Human disorders of axon guidance AA Nugent, AL Kolpak, EC Engle Current opinion in neurobiology 22 (5), 837-843, 2012 | 112 | 2012 |
| Loss of MAFB function in humans and mice causes Duane syndrome, aberrant extraocular muscle innervation, and inner-ear defects JG Park, MA Tischfield, AA Nugent, L Cheng, SA Di Gioia, WM Chan, ... The American Journal of Human Genetics 98 (6), 1220-1227, 2016 | 89 | 2016 |
| Mutant α2-chimaerin signals via bidirectional ephrin pathways in Duane retraction syndrome AA Nugent, JG Park, Y Wei, AP Tenney, NM Gilette, MM DeLisle, ... The Journal of clinical investigation 127 (5), 1664-1682, 2017 | 28 | 2017 |
| Neutral or detrimental effects of TREM2 agonist antibodies in preclinical models of Alzheimer’s disease and multiple sclerosis A Etxeberria, YAA Shen, S Vito, SM Silverman, J Imperio, G Lalehzadeh, ... Journal of Neuroscience 44 (29), 2024 | 7 | 2024 |
| Anti-trem2 antibodies and methods of use thereof H Chen, G Di Paolo, HAO Rui, JW Lewcock, N Moerke, AA Nugent, ... US Patent App. 16/646,536, 2020 | 6 | 2020 |
| DNL343 is an investigational CNS penetrant eIF2B activator that prevents and reverses the effects of neurodegeneration caused by the Integrated Stress Response E Yulyaningsih, JH Suh, MH Fanok, R Chau, H Solanoy, R Takahashi, ... bioRxiv, 2023.08. 21.554203, 2023 | 5 | 2023 |
| Lysosomal storage disorder biomarkers and methods of use thereof A Arguello, G Astarita, A Bhalla, JR Blumenfeld, G Di Paolo, A Henry, ... US Patent App. 17/311,939, 2022 | 4 | 2022 |
| Primate cerebrospinal fluid CHI3L1 reflects brain TREM2 agonism SP Schauer, CH Cho, G Novikova, GA Roth, J Lee, AD Sharma, AR Foley, ... Alzheimer's & Dementia 20 (9), 5861-5888, 2024 | 1 | 2024 |
| Novel FACS based method demonstrates CNS cell-type distribution and efficacy of a BBB penetrant ERT in a mouse model of MPS II JC Ullman, AA Nugent, A Arguello, A Bhalla, T Sandmann, S Lianoglou, ... Molecular Genetics and Metabolism 129 (2), S155, 2020 | 1 | 2020 |
| Brain delivery and efficacy of an intravenously-administered lysosomal enzyme using a blood-brain barrier transport vehicle AG Henry, J Ullman, A Arguello, J Getz, A Bhalla, C Mahon, J Wang, ... Molecular Genetics and Metabolism 129 (2), S72, 2020 | 1 | 2020 |
| DNL343 is an investigational CNS penetrant eukaryotic initiation factor 2B activator that prevents and reverses the effects of neurodegeneration caused by the integrated stress … E Yulyaningsih, JH Suh, M Fanok, R Chau, H Solanoy, R Takahashi, ... Elife 12, RP92173, 2024 | | 2024 |
| SARM1 orthosteric base exchange inhibitors cause subinhibitory SARM1 activation R Leahey, M Weber, CH Cho, S Hur, A Cramer, K Manzanares, B Babin, ... bioRxiv, 2024.08. 06.606489, 2024 | | 2024 |
| Methods for treating dysregulated lipid metabolism G Astarita, G Di Paolo, KL Lin, KM Monroe, AA Nugent, B Van Lengerich US Patent App. 17/296,506, 2022 | | 2022 |
| Procédés de traitement du métabolisme lipidique dérégulé G Astarita, PG Di, KM Monroe, AA Nugent, LB Van | | 2021 |
| Developing Hindbrain Motor Neurons Show Spatial and Temporal Transcriptomic Diversity Mapping to Wiring Decisions M Rose, A Tenney, T Ray, D Creighton, A Gelber, M Tischfield, E Murray, ... JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 80 (6), 564-564, 2021 | | 2021 |
| Methods for treating dysregulated lipid metabolism G ASTARITA, G DI PAOLO, KL LIN, KM MONROE, AA NUGENT, ... | | 2020 |
| Mapping motor neuron diversity in the developing brainstem with a single cell transcriptomic atlas and tissue clearing M Rose, A Tenney, D Creighton, A Gelber, M Tischfield, T Collins, ... JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 79 (6), 658-659, 2020 | | 2020 |
