| TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A AL Brown, OG Wilkins, MJ Keuss, SE Hill, M Zanovello, WC Lee, ... Nature 603 (7899), 131-137, 2022 | 297 | 2022 |
| Truncated stathmin-2 is a marker of TDP-43 pathology in frontotemporal dementia M Prudencio, J Humphrey, S Pickles, AL Brown, SE Hill, JM Kachergus, ... The Journal of clinical investigation 130 (11), 2020 | 170 | 2020 |
| Clonal evolution and heterogeneity of osimertinib acquired resistance mechanisms in EGFR mutant lung cancer N Roper, AL Brown, JS Wei, S Pack, C Trindade, C Kim, O Restifo, S Gao, ... Cell reports medicine 1 (1), 2020 | 134 | 2020 |
| Notch signaling and efficacy of PD-1/PD-L1 blockade in relapsed small cell lung cancer N Roper, MJ Velez, A Chiappori, YS Kim, JS Wei, S Sindiri, N Takahashi, ... Nature Communications 12 (1), 3880, 2021 | 114 | 2021 |
| APOBEC mutagenesis and copy-number alterations are drivers of proteogenomic tumor evolution and heterogeneity in metastatic thoracic tumors N Roper, S Gao, TK Maity, AR Banday, X Zhang, A Venugopalan, ... Cell reports 26 (10), 2651-2666. e6, 2019 | 108 | 2019 |
| Finding driver mutations in cancer: Elucidating the role of background mutational processes AL Brown, M Li, A Goncearenco, AR Panchenko PLoS computational biology 15 (4), e1006981, 2019 | 97 | 2019 |
| FUS ALS-causative mutations impair FUS autoregulation and splicing factor networks through intron retention J Humphrey, N Birsa, C Milioto, M McLaughlin, AM Ule, D Robaldo, ... Nucleic acids research 48 (12), 6889-6905, 2020 | 87 | 2020 |
| Mis-spliced transcripts generate de novo proteins in TDP-43–related ALS/FTD S Seddighi, YA Qi, AL Brown, OG Wilkins, C Bereda, C Belair, YJ Zhang, ... Science Translational Medicine 16 (734), eadg7162, 2024 | 80 | 2024 |
| The era of cryptic exons: implications for ALS-FTD PR Mehta, AL Brown, ME Ward, P Fratta Molecular Neurodegeneration 18 (1), 16, 2023 | 51 | 2023 |
| Cell environment shapes TDP-43 function with implications in neuronal and muscle disease U Šušnjar, N Škrabar, AL Brown, Y Abbassi, H Phatnani, A Cortese, ... Communications biology 5 (1), 314, 2022 | 46 | 2022 |
| HnRNP K mislocalisation is a novel protein pathology of frontotemporal lobar degeneration and ageing and leads to cryptic splicing A Bampton, A Gatt, J Humphrey, S Cappelli, D Bhattacharya, S Foti, ... Acta Neuropathologica 142, 609-627, 2021 | 39 | 2021 |
| Morphological variability is greater at developing than mature mouse neuromuscular junctions AM Mech, AL Brown, G Schiavo, JN Sleigh Journal of Anatomy 237 (4), 603-617, 2020 | 36 | 2020 |
| Unexpected frequency of the pathogenic AR CAG repeat expansion in the general population M Zanovello, K Ibáñez, AL Brown, P Sivakumar, A Bombaci, L Santos, ... Brain 146 (7), 2723-2729, 2023 | 18 | 2023 |
| RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides with STMN-2 cryptic splicing and precedes clinical manifestation in ALS H Spence, FM Waldron, RS Saleeb, AL Brown, OM Rifai, M Gilodi, F Read, ... Acta Neuropathologica 147 (1), 50, 2024 | 14 | 2024 |
| Correlates of auditory decision-making in prefrontal, auditory, and basal lateral amygdala cortical areas JL Napoli, CR Camalier, AL Brown, J Jacobs, MM Mishkin, BB Averbeck Journal of Neuroscience 41 (6), 1301-1316, 2021 | 11 | 2021 |
| Creation of de novo cryptic splicing for ALS and FTD precision medicine OG Wilkins, MZYJ Chien, JJ Wlaschin, S Barattucci, P Harley, F Mattedi, ... Science 386 (6717), 61-69, 2024 | 6 | 2024 |
| TDP-43 loss induces extensive cryptic polyadenylation in ALS/FTD S Bryce-Smith, AL Brown, PR Mehta, F Mattedi, A Mikheenko, S Barattucci, ... BioRxiv, 2024.01. 22.576625, 2024 | 6 | 2024 |
| NOS1AP is a novel molecular target and critical factor in TDP-43 pathology S Cappelli, A Spalloni, F Feiguin, G Visani, U Šušnjar, AL Brown, ... Brain Communications 4 (5), fcac242, 2022 | 5 | 2022 |
| Blocking incidental frustration during bargaining MES Vargas, AL Brown, CM Durkee, H Sim Cognition and Emotion 33 (2), 146-156, 2019 | 4 | 2019 |
| Solving A Decade-Long Mystery: Neurons Hold The Key To Rare Neurological Diseases AL Brown TheScienceBreaker 9 (1), 2023 | | 2023 |