| The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53 M Scheffner, BA Werness, JM Huibregtse, AJ Levine, PM Howley cell 63 (6), 1129-1136, 1990 | 5394 | 1990 |
| The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53 M Scheffner, JM Huibregtse, RD Vierstra, PM Howley Cell 75 (3), 495-505, 1993 | 3201 | 1993 |
| A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase. JM Huibregtse, M Scheffner, S Beaudenon, PM Howley Proceedings of the National Academy of Sciences 92 (7), 2563-2567, 1995 | 1509 | 1995 |
| Protein ubiquitination involving an E1–E2–E3 enzyme ubiquitin thioester cascade M Scheffner, U Nuber, JM Huibregtse Nature 373 (6509), 81-83, 1995 | 1378 | 1995 |
| A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18. JM Huibregtse, M Scheffner, PM Howley The EMBO journal 10 (13), 4129-4135, 1991 | 1171 | 1991 |
| In Vivo Ubiquitination and Proteasome-mediated Degradation of p53 CG Maki, JM Huibregtse, PM Howley Cancer research 56 (11), 2649-2654, 1996 | 883 | 1996 |
| Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade L Huang, E Kinnucan, G Wang, S Beaudenon, PM Howley, JM Huibregtse, ... Science 286 (5443), 1321-1326, 1999 | 797 | 1999 |
| Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53 JM Huibregtse, M Scheffner, PM Howley Molecular and cellular biology 13 (2), 775-784, 1993 | 756 | 1993 |
| Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase S Nakagawa, JM Huibregtse Molecular and cellular biology 20 (21), 8244-8253, 2000 | 624 | 2000 |
| A PPxY motif within the VP40 protein of Ebola virus interacts physically and functionally with a ubiquitin ligase: implications for filovirus budding RN Harty, ME Brown, G Wang, J Huibregtse, FP Hayes Proceedings of the National Academy of Sciences 97 (25), 13871-13876, 2000 | 579 | 2000 |
| Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways C Zhao, C Denison, JM Huibregtse, S Gygi, RM Krug Proceedings of the National Academy of Sciences 102 (29), 10200-10205, 2005 | 578 | 2005 |
| Mycobacterial disease and impaired IFN-γ immunity in humans with inherited ISG15 deficiency D Bogunovic, M Byun, LA Durfee, A Abhyankar, O Sanal, D Mansouri, ... Science 337 (6102), 1684-1688, 2012 | 574 | 2012 |
| Localization of the E6-AP regions that direct human papillomavirus E6 binding, association with p53, and ubiquitination of associated proteins JM Huibregtse, M Scheffner, PM Howley Molecular and cellular biology, 1993 | 566 | 1993 |
| The transcriptional transactivation function of wild‐type p53 is inhibited by SV40 large T‐antigen and by HPV‐16 E6 oncoprotein. JA Mietz, T Unger, JM Huibregtse, PM Howley The EMBO journal 11 (13), 5013-5020, 1992 | 508 | 1992 |
| Interactions of HPV E6 and E7 oncoproteins with tumour suppressor gene products. K Münger, M Scheffner, JM Huibregtse, PM Howley Cancer surveys 12, 197-217, 1992 | 426 | 1992 |
| The ISG15 conjugation system broadly targets newly synthesized proteins: implications for the antiviral function of ISG15 LA Durfee, N Lyon, K Seo, JM Huibregtse Molecular cell 38 (5), 722-732, 2010 | 387 | 2010 |
| Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53. M Scheffner, JM Huibregtse, PM Howley Proceedings of the National Academy of Sciences 91 (19), 8797-8801, 1994 | 371 | 1994 |
| The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-α/β-induced ubiquitin-like protein C Zhao, SL Beaudenon, ML Kelley, MB Waddell, W Yuan, BA Schulman, ... Proceedings of the National Academy of Sciences 101 (20), 7578-7582, 2004 | 367 | 2004 |
| Polyubiquitination by HECT E3s and the determinants of chain type specificity HC Kim, JM Huibregtse Molecular and cellular biology 29 (12), 3307-3318, 2009 | 357 | 2009 |
| The role of E6AP in the regulation of p53 protein levels in human papillomavirus (HPV)-positive and HPV-negative cells AL Talis, JM Huibregtse, PM Howley Journal of Biological Chemistry 273 (11), 6439-6445, 1998 | 349 | 1998 |