| Nimotuzumab, an antitumor antibody that targets the epidermal growth factor receptor, blocks ligand binding while permitting the active receptor conformation A Talavera, R Friemann, S Gómez-Puerta, C Martinez-Fleites, G Garrido, ... Cancer research 69 (14), 5851-5859, 2009 | 259 | 2009 |
| AAV vectors: The Rubik’s cube of human gene therapy A Pupo, A Fernández, SH Low, A François, L Suárez-Amarán, ... Molecular Therapy 30 (12), 3515-3541, 2022 | 199 | 2022 |
| Connexinopathies: a structural and functional glimpse IE García, P Prado, A Pupo, O Jara, D Rojas-Gómez, P Mujica, ... BMC cell biology 17, 71-87, 2016 | 64 | 2016 |
| From hyperactive connexin26 hemichannels to impairments in epidermal calcium gradient and permeability barrier in the keratitis-ichthyosis-deafness syndrome IE Garcia, F Bosen, P Mujica, A Pupo, C Flores-Munoz, O Jara, ... Journal of Investigative Dermatology 136 (3), 574-583, 2016 | 54 | 2016 |
| Structural and functional characterization of a recombinant sticholysin I (rSt I) from the sea anemone Stichodactyla helianthus F Pazos, A Valle, D Martínez, A Ramírez, L Calderón, A Pupo, M Tejuca, ... Toxicon 48 (8), 1083-1094, 2006 | 43 | 2006 |
| Extracellular cysteine in connexins: role as redox sensors MA Retamal, IE García, BI Pinto, A Pupo, D Báez, J Stehberg, R Del Rio, ... Frontiers in physiology 7, 1, 2016 | 42 | 2016 |
| Affinity maturation and fine functional mapping of an antibody fragment against a novel neutralizing epitope on human vascular endothelial growth factor H Lamdan, JV Gavilondo, Y Muñoz, A Pupo, V Huerta, A Musacchio, ... Molecular BioSystems 9 (8), 2097-2106, 2013 | 39 | 2013 |
| Molecular mechanism underlying β1 regulation in voltage-and calcium-activated potassium (BK) channels K Castillo, GF Contreras, A Pupo, YP Torres, A Neely, C González, ... Proceedings of the National Academy of Sciences 112 (15), 4809-4814, 2015 | 38 | 2015 |
| Deciphering the molecular bases of the biological effects of antibodies against Interleukin-2: a versatile platform for fine epitope mapping G Rojas, A Pupo, K Leon, J Avellanet, T Carmenate, S Sidhu Immunobiology 218 (1), 105-113, 2013 | 33 | 2013 |
| Fine epitope specificity of antibodies against interleukin-2 explains their paradoxical immunomodulatory effects G Rojas, Y Cabrera Infante, A Pupo, T Carmenate MAbs 6 (1), 273-285, 2014 | 28 | 2014 |
| Analysing an allelic series of rare missense variants of CACNA1I in a Swedish schizophrenia cohort D Baez-Nieto, A Allen, S Akers-Campbell, L Yang, N Budnik, A Pupo, ... Brain 145 (5), 1839-1853, 2022 | 27 | 2022 |
| Engineering the Binding Site of an Antibody against N-Glycolyl GM3: From Functional Mapping to Novel Anti-ganglioside Specificities G Rojas, A Pupo, S Gómez, U Krengel, E Moreno ACS Chemical Biology 8 (2), 376-386, 2013 | 25 | 2013 |
| Predicting functional residues in Plasmodium falciparum plasmepsins by combining sequence and structural analysis with molecular dynamics simulations PA Valiente, PR Batista, A Pupo, T Pons, A Valencia, PG Pascutti Proteins: Structure, Function, and Bioinformatics 73 (2), 440-457, 2008 | 24 | 2008 |
| Voltage-dependent BK and Hv1 channels expressed in non-excitable tissues: New therapeutics opportunities as targets in human diseases FJ Morera, J Saravia, JP Pontigo, L Vargas-Chacoff, GF Contreras, ... Pharmacological Research 101, 56-64, 2015 | 23 | 2015 |
| Control of lysosomal-mediated cell death by the pH-dependent calcium channel RECS1 P Pihán, F Lisbona, J Borgonovo, S Edwards-Jorquera, P Nunes-Hasler, ... Science advances 7 (46), eabe5469, 2021 | 22 | 2021 |
| The syndromic deafness mutation G12R impairs fast and slow gating in Cx26 hemichannels IE García, F Villanelo, GF Contreras, A Pupo, BI Pinto, JE Contreras, ... Journal of General Physiology 150 (5), 697-711, 2018 | 22 | 2018 |
| Pharmacological modulation of proton channel Hv1 in cancer therapy: Future perspectives A Fernández, A Pupo, K Mena-Ulecia, C Gonzalez Molecular pharmacology 90 (3), 385-402, 2016 | 22 | 2016 |
| Delineating the functional map of the interaction between nimotuzumab and the epidermal growth factor receptor Y Tundidor, CP García-Hernández, A Pupo, YC Infante, G Rojas MAbs 6 (4), 1013-1025, 2014 | 22 | 2014 |
| A combinatorial mutagenesis approach for functional epitope mapping on phage-displayed target antigen: application to antibodies against epidermal growth factor YC Infante, A Pupo, G Rojas MAbs 6 (3), 637-648, 2014 | 20 | 2014 |
| Calcium binding and voltage gating in Cx46 hemichannels BI Pinto, A Pupo, IE García, K Mena-Ulecia, AD Martínez, R Latorre, ... Scientific Reports 7 (1), 15851, 2017 | 18 | 2017 |
Agustin D MartinezCentro Interdisciplinario de Neurociencia de Valparaíso, Universidad de ValparaísoVerified email at uv.cl