| CpG motifs in bacterial DNA trigger direct B-cell activation AM Krieg, AK Yi, S Matson, TJ Waldschmidt, GA Bishop, R Teasdale, ... Nature 374 (6522), 546-549, 1995 | 4815 | 1995 |
| CPG MOTIFS IN BACTERIAL DNA AND THEIR IMMUNE EFFECTS AM Krieg Annual review of immunology 20 (1), 709-760, 2002 | 3423 | 2002 |
| Therapeutic potential of Toll-like receptor 9 activation AM Krieg Nature reviews Drug discovery 5 (6), 471-484, 2006 | 2404 | 2006 |
| CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma. DM Klinman, AK Yi, SL Beaucage, J Conover, AM Krieg Proceedings of the national academy of sciences 93 (7), 2879-2883, 1996 | 2026 | 1996 |
| Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848 M Jurk, F Heil, J Vollmer, C Schetter, AM Krieg, H Wagner, G Lipford, ... Nature immunology 3 (6), 499-499, 2002 | 1368 | 2002 |
| CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity RS Chu, OS Targoni, AM Krieg, PV Lehmann, CV Harding The Journal of experimental medicine 186 (10), 1623-1631, 1997 | 1356 | 1997 |
| Identification of CpG oligonucleotide sequences with high induction of IFN‐α/β in plasmacytoid dendritic cells A Krug, S Rothenfusser, V Hornung, B Jahrsdörfer, S Blackwell, ZK Ballas, ... European journal of immunology 31 (7), 2154-2163, 2001 | 1202 | 2001 |
| Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA. ZK Ballas, WL Rasmussen, AM Krieg Journal of immunology (Baltimore, Md.: 1950) 157 (5), 1840-1845, 1996 | 1087 | 1996 |
| Toll‐like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL‐12 A Krug, A Towarowski, S Britsch, S Rothenfusser, V Hornung, R Bals, ... European journal of immunology 31 (10), 3026-3037, 2001 | 1076 | 2001 |
| CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen HL Davis, R Weeranta, TJ Waldschmidt, L Tygrett, J Schorr, AM Krieg The Journal of Immunology 160 (2), 870-876, 1998 | 999 | 1998 |
| CpG DNA: a potent signal for growth, activation, and maturation of human dendritic cells G Hartmann, GJ Weiner, AM Krieg Proceedings of the National Academy of Sciences 96 (16), 9305-9310, 1999 | 906 | 1999 |
| Mechanism and function of a newly identified CpG DNA motif in human primary B cells G Hartmann, AM Krieg The Journal of Immunology 164 (2), 944-953, 2000 | 896 | 2000 |
| Delineation of a CpG phosphorothioate oligodeoxynucleotide for activating primate immune responses in vitro and in vivo G Hartmann, RD Weeratna, ZK Ballas, P Payette, S Blackwell, I Suparto, ... The Journal of Immunology 164 (3), 1617-1624, 2000 | 836 | 2000 |
| Immunostimulatory nucleic acid molecules AM Krieg, J Kline, D Klinman, AD Steinberg US Patent 6,207,646, 2001 | 825* | 2001 |
| Human plasmacytoid dendritic cells activated by CpG oligodeoxynucleotides induce the generation of CD4+ CD25+ regulatory T cells EA Moseman, X Liang, AJ Dawson, A Panoskaltsis-Mortari, AM Krieg, ... The Journal of Immunology 173 (7), 4433-4442, 2004 | 812 | 2004 |
| Characterization of three CpG oligodeoxynucleotide classes with distinct immunostimulatory activities J Vollmer, R Weeratna, P Payette, M Jurk, C Schetter, M Laucht, T Wader, ... European journal of immunology 34 (1), 251-262, 2004 | 776 | 2004 |
| Rapid and strong human CD8+ T cell responses to vaccination with peptide, IFA, and CpG oligodeoxynucleotide 7909 DE Speiser, D Liénard, N Rufer, V Rubio-Godoy, D Rimoldi, F Lejeune, ... The Journal of clinical investigation 115 (3), 739-746, 2005 | 772 | 2005 |
| Cutting edge: modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma JN Kline, TJ Waldschmidt, TR Businga, JE Lemish, JV Weinstock, ... The Journal of Immunology 160 (6), 2555-2559, 1998 | 771 | 1998 |
| Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization GJ Weiner, HM Liu, JE Wooldridge, CE Dahle, AM Krieg Proceedings of the National Academy of Sciences 94 (20), 10833-10837, 1997 | 734 | 1997 |
| Immunotherapeutic applications of CpG oligodeoxynucleotide TLR9 agonists J Vollmer, AM Krieg Advanced drug delivery reviews 61 (3), 195-204, 2009 | 698 | 2009 |
Joel N KlineProfessor of Medicine, University of IowaVerified email at uiowa.edu
