| Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating … P Godoy, NJ Hewitt, U Albrecht, ME Andersen, N Ansari, S Bhattacharya, ... Archives of toxicology 87, 1315-1530, 2013 | 1464 | 2013 |
| The Nrf2 cell defence pathway: Keap1-dependent and-independent mechanisms of regulation HK Bryan, A Olayanju, CE Goldring, BK Park Biochemical pharmacology 85 (6), 705-717, 2013 | 1174 | 2013 |
| Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease CC Bell, DFG Hendriks, SML Moro, E Ellis, J Walsh, A Renblom, ... Scientific reports 6 (1), 25187, 2016 | 721 | 2016 |
| Mechanistic biomarkers provide early and sensitive detection of acetaminophen‐induced acute liver injury at first presentation to hospital DJ Antoine, JW Dear, PS Lewis, V Platt, J Coyle, M Masson, ... Hepatology 58 (2), 777-787, 2013 | 489 | 2013 |
| Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes M Baxter, S Withey, S Harrison, CP Segeritz, F Zhang, R Atkinson-Dell, ... Journal of hepatology 62 (3), 581-589, 2015 | 407 | 2015 |
| The Nrf2–Keap1 defence pathway: role in protection against drug-induced toxicity IM Copple, CE Goldring, NR Kitteringham, BK Park Toxicology 246 (1), 24-33, 2008 | 397 | 2008 |
| Comparison of hepatic 2D sandwich cultures and 3D spheroids for long-term toxicity applications: a multicenter study CC Bell, ACA Dankers, VM Lauschke, R Sison-Young, R Jenkins, ... Toxicological Sciences 162 (2), 655-666, 2018 | 311 | 2018 |
| Physical and functional interaction of sequestosome 1 with Keap1 regulates the Keap1-Nrf2 cell defense pathway IM Copple, A Lister, AD Obeng, NR Kitteringham, RE Jenkins, R Layfield, ... Journal of Biological Chemistry 285 (22), 16782-16788, 2010 | 302 | 2010 |
| Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy A Lister, T Nedjadi, NR Kitteringham, F Campbell, E Costello, B Lloyd, ... Molecular cancer 10, 1-13, 2011 | 297 | 2011 |
| ERK5: structure, regulation and function GN Nithianandarajah-Jones, B Wilm, CEP Goldring, J Müller, MJ Cross Cellular signalling 24 (11), 2187-2196, 2012 | 288 | 2012 |
| Activation of hepatic Nrf2 in vivo by acetaminophen in CD‐1 mice CEP Goldring, NR Kitteringham, R Elsby, LE Randle, YN Clement, ... Hepatology 39 (5), 1267-1276, 2004 | 252 | 2004 |
| Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity—implications for therapeutic targeting of Nrf2 A Olayanju, IM Copple, HK Bryan, GT Edge, RL Sison, MW Wong, ZQ Lai, ... Free Radical Biology and Medicine 78, 202-212, 2015 | 237 | 2015 |
| Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver NR Kitteringham, A Abdullah, J Walsh, L Randle, RE Jenkins, R Sison, ... Journal of proteomics 73 (8), 1612-1631, 2010 | 225 | 2010 |
| Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models RJ Weaver, EA Blomme, AE Chadwick, IM Copple, HHJ Gerets, ... Nature Reviews Drug Discovery 19 (2), 131-148, 2020 | 222 | 2020 |
| Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice H Cai, E Scott, A Kholghi, C Andreadi, A Rufini, A Karmokar, RG Britton, ... Science translational medicine 7 (298), 298ra117-298ra117, 2015 | 193 | 2015 |
| Increased constitutive c-Jun N-terminal kinase signaling in mice lacking glutathione S-transferase Pi R Elsby, NR Kitteringham, CE Goldring, CA Lovatt, M Chamberlain, ... Journal of Biological Chemistry 278 (25), 22243-22249, 2003 | 185 | 2003 |
| The hepatotoxic metabolite of acetaminophen directly activates the Keap1‐Nrf2 cell defense system IM Copple, CE Goldring, RE Jenkins, AJL Chia, LE Randle, JD Hayes, ... Hepatology 48 (4), 1292-1301, 2008 | 176 | 2008 |
| A novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3 HK Bone, AS Nelson, CE Goldring, D Tosh, MJ Welham Journal of cell science 124 (12), 1992-2000, 2011 | 138 | 2011 |
| Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation VM Lauschke, SU Vorrink, SML Moro, F Rezayee, Å Nordling, ... Hepatology 64 (5), 1743-1756, 2016 | 124 | 2016 |
| The keap1-nrf2 cellular defense pathway: mechanisms of regulation and role in protection against drug-induced toxicity IM Copple, CE Goldring, NR Kitteringham, BK Park Adverse Drug Reactions, 233-266, 2010 | 120 | 2010 |
Professor Ian CoppleDepartment of Pharmacology & Therapeutics, University of LiverpoolVerified email at liverpool.ac.uk