| A microRNA miR-34a-regulated bimodal switch targets Notch in colon cancer stem cells P Bu, KY Chen, JH Chen, L Wang, J Walters, YJ Shin, JP Goerger, J Sun, ... Cell stem cell 12 (5), 602-615, 2013 | 398 | 2013 |
| Aldolase B-mediated fructose metabolism drives metabolic reprogramming of colon cancer liver metastasis P Bu, KY Chen, K Xiang, C Johnson, SB Crown, N Rakhilin, Y Ai, L Wang, ... Cell metabolism 27 (6), 1249-1262. e4, 2018 | 264 | 2018 |
| A miR-34a-numb feedforward loop triggered by inflammation regulates asymmetric stem cell division in intestine and colon cancer P Bu, L Wang, KY Chen, T Srinivasan, PKL Murthy, KL Tung, AK Varanko, ... Cell stem cell 18 (2), 189-202, 2016 | 160 | 2016 |
| MESH1 is a cytosolic NADPH phosphatase that regulates ferroptosis CKC Ding, J Rose, T Sun, J Wu, PH Chen, CC Lin, WH Yang, KY Chen, ... Nature Metabolism 2 (3), 270-277, 2020 | 153 | 2020 |
| miR-1269 promotes metastasis and forms a positive feedback loop with TGF-β P Bu, L Wang, KY Chen, N Rakhilin, J Sun, A Closa, KL Tung, S King, ... Nature communications 6 (1), 6879, 2015 | 131 | 2015 |
| Matrix metalloproteinase inhibitors enhance the efficacy of frontline drugs against Mycobacterium tuberculosis Y Xu, L Wang, MD Zimmerman, KY Chen, L Huang, DJ Fu, F Kaya, ... PLoS pathogens 14 (4), e1006974, 2018 | 72 | 2018 |
| Fucosylation deficiency in mice leads to colitis and adenocarcinoma Y Wang, D Huang, KY Chen, M Cui, W Wang, X Huang, A Awadellah, Q Li, ... Gastroenterology 152 (1), 193-205. e10, 2017 | 69 | 2017 |
| NOTCH signaling regulates asymmetric cell fate of fast-and slow-cycling colon cancer–initiating cells T Srinivasan, J Walters, P Bu, EB Than, KL Tung, KY Chen, N Panarelli, ... Cancer research 76 (11), 3411-3421, 2016 | 64 | 2016 |
| Notch signalling regulates asymmetric division and inter-conversion between lgr5 and bmi1 expressing intestinal stem cells T Srinivasan, EB Than, P Bu, KL Tung, KY Chen, L Augenlicht, SM Lipkin, ... Scientific reports 6 (1), 26069, 2016 | 52 | 2016 |
| A metabolic signature of colon cancer initiating cells KY Chen, X Liu, P Bu, CS Lin, N Rakhilin, JW Locasale, X Shen 2014 36th annual international conference of the IEEE Engineering in …, 2014 | 52 | 2014 |
| A Notch positive feedback in the intestinal stem cell niche is essential for stem cell self‐renewal KY Chen, T Srinivasan, KL Tung, JM Belmonte, L Wang, PKL Murthy, ... Molecular Systems Biology 13 (4), 927, 2017 | 50 | 2017 |
| Asymmetric division: a marker for cancer stem cells? P Bu, KY Chen, SM Lipkin, X Shen Oncotarget 4 (7), 950, 2013 | 48 | 2013 |
| The regulation of ferroptosis by MESH1 through the activation of the integrative stress response CC Lin, CKC Ding, T Sun, J Wu, KY Chen, P Zhou, JT Chi Cell Death & Disease 12 (8), 727, 2021 | 36 | 2021 |
| Single-cell transcriptomics reveals heterogeneity and drug response of human colorectal cancer organoids KY Chen, T Srinivasan, C Lin, KL Tung, Z Gao, DS Hsu, SM Lipkin, ... 2018 40th Annual International Conference of the IEEE Engineering in …, 2018 | 35 | 2018 |
| Comprehensive models of human primary and metastatic colorectal tumors in immunodeficient and immunocompetent mice by chemokine targeting HJ Chen, J Sun, Z Huang, H Hou Jr, M Arcilla, N Rakhilin, DJ Joe, J Choi, ... Nature biotechnology 33 (6), 656-660, 2015 | 35 | 2015 |
| miR-34a is a microRNA safeguard for Citrobacter-induced inflammatory colon oncogenesis L Wang, E Wang, Y Wang, R Mines, K Xiang, Z Sun, G Zhou, KY Chen, ... Elife 7, e39479, 2018 | 33 | 2018 |
| Chromatin remodeling of colorectal cancer liver metastasis is mediated by an HGF‐PU. 1‐DPP4 axis L Wang, E Wang, J Prado Balcazar, Z Wu, K Xiang, Y Wang, Q Huang, ... Advanced Science 8 (19), 2004673, 2021 | 22 | 2021 |
| Development of a precision medicine pipeline to identify personalized treatments for colorectal cancer E Altunel, RS Roghani, KY Chen, SY Kim, S McCall, KE Ware, X Shen, ... BMC cancer 20, 1-10, 2020 | 19 | 2020 |
| Integrated chromatin and transcriptomic profiling of patient-derived colon cancer organoids identifies personalized drug targets to overcome oxaliplatin resistance KL Tung, KY Chen, M Negrete, T Chen, A Safi, AA Aljamal, L Song, ... Genes & diseases 8 (2), 203-214, 2021 | 17 | 2021 |
| Mammalian stringent-like response mediated by the cytosolic NADPH phosphatase MESH1 CKC Ding, J Rose, J Wu, T Sun, KY Chen, PH Chen, E Xu, S Tian, ... Biorxiv, 325266, 2018 | 13 | 2018 |
Xiling ShenAssociate Professor of Biomedical Engineering, Duke UniversityVerified email at duke.edu