| Bone morphogenetic proteins DI Chen, M Zhao, GR Mundy Growth factors 22 (4), 233-241, 2004 | 3104 | 2004 |
| Stimulation of bone formation in vitro and in rodents by statins G Mundy, R Garrett, S Harris, J Chan, D Chen, G Rossini, B Boyce, ... Science 286 (5446), 1946-1949, 1999 | 2659 | 1999 |
| Osteoarthritis: toward a comprehensive understanding of pathological mechanism DI Chen, J Shen, W Zhao, T Wang, L Han, JL Hamilton, HJ Im Bone research 5 (1), 1-13, 2017 | 1232 | 2017 |
| Implant-derived magnesium induces local neuronal production of CGRP to promote bone fracture healing in rats LQ Zhang Y, Xu J, Ruan Y, Yu PM, O’Laughlin M, Wise H, Chen D, Tian L, Shi D ... Nature Medicine 22 (10), 1160-1169, 2016 | 932 | 2016 |
| MicroRNA-204 regulates Runx2 protein expression and mesenchymal progenitor cell differentiation J Huang, L Zhao, L Xing, D Chen Stem cells 28 (2), 357-364, 2010 | 803 | 2010 |
| Activation of β‐catenin signaling in articular chondrocytes leads to osteoarthritis‐like phenotype in adult β‐catenin conditional activation mice M Zhu, D Tang, Q Wu, S Hao, M Chen, C Xie, RN Rosier, RJ O'Keefe, ... Journal of Bone and Mineral Research 24 (1), 12-21, 2009 | 601 | 2009 |
| Osteoarthritis pathogenesis: a review of molecular mechanisms B Xia, D Chen, J Zhang, S Hu, H Jin, P Tong Calcified tissue international 95, 495-505, 2014 | 600 | 2014 |
| Differential roles for bone morphogenetic protein (BMP) receptor type IB and IA in differentiation and specification of mesenchymal precursor cells to osteoblast and adipocyte … D Chen, X Ji, MA Harris, JQ Feng, G Karsenty, AJ Celeste, V Rosen, ... The Journal of cell biology 142 (1), 295-305, 1998 | 569 | 1998 |
| MMP13 is a critical target gene during the progression of osteoarthritis M Wang, ER Sampson, H Jin, J Li, QH Ke, HJ Im, D Chen Arthritis research & therapy 15, 1-11, 2013 | 567 | 2013 |
| Ankylosing spondylitis: etiology, pathogenesis, and treatments W Zhu, X He, K Cheng, L Zhang, D Chen, X Wang, G Qiu, X Cao, X Weng Bone research 7 (1), 22, 2019 | 472 | 2019 |
| The BMP signaling and in vivo bone formation X Cao, D Chen Gene 357 (1), 1-8, 2005 | 456 | 2005 |
| Smad5 and DPC4 are key molecules in mediating BMP-2-induced osteoblastic differentiation of the pluripotent mesenchymal precursor cell line C2C12 R Nishimura, Y Kato, D Chen, SE Harris, GR Mundy, T Yoneda Journal of Biological Chemistry 273 (4), 1872-1879, 1998 | 381 | 1998 |
| Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitro IR Garrett, D Chen, G Gutierrez, M Zhao, A Escobedo, G Rossini, ... The Journal of clinical investigation 111 (11), 1771-1782, 2003 | 371 | 2003 |
| Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts H Kaneki, R Guo, D Chen, Z Yao, EM Schwarz, YE Zhang, BF Boyce, ... Journal of Biological Chemistry 281 (7), 4326-4333, 2006 | 361 | 2006 |
| Wnt/β-catenin signaling activates bone morphogenetic protein 2 expression in osteoblasts R Zhang, BO Oyajobi, SE Harris, D Chen, C Tsao, HW Deng, M Zhao Bone 52 (1), 145-156, 2013 | 360 | 2013 |
| Intestinal epithelial vitamin D receptor deletion leads to defective autophagy in colitis S Wu, Y Zhang, R Lu, Y Xia, D Zhou, EO Petrof, EC Claud, D Chen, ... Gut 64 (7), 1082-1094, 2015 | 353 | 2015 |
| E3 ubiquitin ligase Smurf1 mediates core-binding factor α1/Runx2 degradation and plays a specific role in osteoblast differentiation M Zhao, M Qiao, BO Oyajobi, GR Mundy, D Chen Journal of Biological Chemistry 278 (30), 27939-27944, 2003 | 353 | 2003 |
| Bone morphogenetic protein 2 (BMP-2) enhances BMP-3, BMP-4, and bone cell differentiation marker gene expression during the induction of mineralized bone matrix formation in … D Chen, MA Harris, G Rossini, CR Dunstan, SL Dallas, JQ Feng, ... Calcified tissue international 60, 283-290, 1997 | 350 | 1997 |
| Inhibition of β‐catenin signaling in articular chondrocytes results in articular cartilage destruction M Zhu, M Chen, M Zuscik, Q Wu, YJ Wang, RN Rosier, RJ O'Keefe, ... Arthritis & Rheumatism: Official Journal of the American College of …, 2008 | 333 | 2008 |
| Regulation of chondrogenesis and chondrocyte differentiation by stress MJ Zuscik, MJ Hilton, X Zhang, D Chen, RJ O’Keefe The Journal of clinical investigation 118 (2), 429-438, 2008 | 332 | 2008 |
Regis O'KeefeChairman, Department of Orthopaedic Surgery, Washington University in St LouisVerified email at wustl.edu