| Small-molecule ligand docking into comparative models with Rosetta SA Combs, SL DeLuca, SH DeLuca, GH Lemmon, DP Nannemann, ... Nature protocols 8 (7), 1277-1298, 2013 | 215 | 2013 |
| A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses JM Steichen, YC Lin, C Havenar-Daughton, S Pecetta, G Ozorowski, ... Science 366 (6470), eaax4380, 2019 | 214 | 2019 |
| Human peripheral blood antibodies with long HCDR3s are established primarily at original recombination using a limited subset of germline genes BS Briney, JR Willis, JE Crowe Jr PloS one 7 (5), e36750, 2012 | 180 | 2012 |
| Vaccination induces HIV broadly neutralizing antibody precursors in humans DJ Leggat, KW Cohen, JR Willis, WJ Fulp, AC Decamp, O Kalyuzhniy, ... Science 378 (6623), eadd6502, 2022 | 164 | 2022 |
| Structure-based design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes and eliminate CD4 binding DW Kulp, JM Steichen, M Pauthner, X Hu, T Schiffner, A Liguori, ... Nature communications 8 (1), 1655, 2017 | 160 | 2017 |
| Human germline antibody gene segments encode polyspecific antibodies JR Willis, BS Briney, SL DeLuca, JE Crowe Jr, J Meiler PLoS computational biology 9 (4), e1003045, 2013 | 144 | 2013 |
| High-throughput antibody sequencing reveals genetic evidence of global regulation of the naive and memory repertoires that extends across individuals BS Briney, JR Willis, BA McKinney, JE Crowe Genes & Immunity 13 (6), 469-473, 2012 | 105 | 2012 |
| Location and length distribution of somatic hypermutation-associated DNA insertions and deletions reveals regions of antibody structural plasticity BS Briney, JR Willis, JE Crowe Genes & Immunity 13 (7), 523-529, 2012 | 90 | 2012 |
| Frequency and genetic characterization of V (DD) J recombinants in the human peripheral blood antibody repertoire BS Briney, JR Willis, MD Hicar, JW Thomas, JE Crowe Jr Immunology 137 (1), 56-64, 2012 | 81 | 2012 |
| Maturation-induced cloaking of neutralization epitopes on HIV-1 particles AS Joyner, JR Willis, JE Crowe Jr, C Aiken PLoS pathogens 7 (9), e1002234, 2011 | 58 | 2011 |
| Tissue-specific expressed antibody variable gene repertoires BS Briney, JR Willis, JA Finn, BA McKinney, JE Crowe Jr PLoS One 9 (6), e100839, 2014 | 42 | 2014 |
| Redesigned HIV antibodies exhibit enhanced neutralizing potency and breadth JR Willis, G Sapparapu, S Murrell, JP Julien, V Singh, HG King, Y Xia, ... The Journal of clinical investigation 125 (6), 2523-2531, 2015 | 36 | 2015 |
| Membrane-bound mRNA immunogens lower the threshold to activate HIV Env V2 apex-directed broadly neutralizing B cell precursors in humanized mice E Melzi, JR Willis, KM Ma, YC Lin, S Kratochvil, ZT Berndsen, EA Landais, ... Immunity 55 (11), 2168-2186. e6, 2022 | 34 | 2022 |
| Human immunoglobulin repertoire analysis guides design of vaccine priming immunogens targeting HIV V2-apex broadly neutralizing antibody precursors JR Willis, ZT Berndsen, KM Ma, JM Steichen, T Schiffner, E Landais, ... Immunity 55 (11), 2149-2167. e9, 2022 | 33 | 2022 |
| Improving loop modeling of the antibody complementarity-determining region 3 using knowledge-based restraints JA Finn, J Koehler Leman, JR Willis, A Cisneros III, JE Crowe Jr, J Meiler PloS one 11 (5), e0154811, 2016 | 32 | 2016 |
| Long antibody HCDR3s from HIV-naive donors presented on a PG9 neutralizing antibody background mediate HIV neutralization JR Willis, JA Finn, B Briney, G Sapparapu, V Singh, H King, ... Proceedings of the National Academy of Sciences 113 (16), 4446-4451, 2016 | 30 | 2016 |
| Rapid discovery of diverse neutralizing SARS-CoV-2 antibodies from large-scale synthetic phage libraries TZ Yuan, P Garg, L Wang, JR Willis, E Kwan, AGL Hernandez, E Tuscano, ... MAbs 14 (1), 2002236, 2022 | 25 | 2022 |
| PyIR: a scalable wrapper for processing billions of immunoglobulin and T cell receptor sequences using IgBLAST C Soto, JA Finn, JR Willis, SB Day, RS Sinkovits, T Jones, S Schmitz, ... BMC bioinformatics 21, 1-7, 2020 | 24 | 2020 |
| Structure-based design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes and eliminate CD4 binding. Nat Commun 8: 1655 DW Kulp, JM Steichen, M Pauthner, X Hu, T Schiffner, A Liguori, ... | 23 | 2017 |
| PyRosetta Jupyter notebooks teach biomolecular structure prediction and design KH Le, J Adolf-Bryfogle, JC Klima, S Lyskov, JW Labonte, S Bertolani, ... The Biophysicist 2 (1), 108-122, 2021 | 16 | 2021 |
James CroweVanderbilt University Medical CenterVerified email at vanderbilt.edu