| Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease EJ Slow, J van Raamsdonk, D Rogers, SH Coleman, RK Graham, Y Deng, ... Human molecular genetics 12 (13), 1555-1567, 2003 | 966 | 2003 |
| Deletion of the Mitochondrial Superoxide Dismutase sod-2 Extends Lifespan in Caenorhabditis elegans JM Van Raamsdonk, S Hekimi PLoS genetics 5 (2), e1000361, 2009 | 651 | 2009 |
| Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease CL Wellington, LM Ellerby, CA Gutekunst, D Rogers, S Warby, ... Journal of Neuroscience 22 (18), 7862-7872, 2002 | 513 | 2002 |
| Beneficial and detrimental effects of reactive oxygen species on lifespan: a comprehensive review of comparative and experimental studies HJ Shields, A Traa, JM Van Raamsdonk Frontiers in cell and developmental biology 9, 628157, 2021 | 412 | 2021 |
| Superoxide dismutase is dispensable for normal animal lifespan JM Van Raamsdonk, S Hekimi Proceedings of the National Academy of Sciences 109 (15), 5785-5790, 2012 | 396 | 2012 |
| Cognitive dysfunction precedes neuropathology and motor abnormalities in the YAC128 mouse model of Huntington's disease JM Van Raamsdonk, J Pearson, EJ Slow, SM Hossain, BR Leavitt, ... Journal of Neuroscience 25 (16), 4169-4180, 2005 | 389 | 2005 |
| Wild‐type huntingtin protects neurons from excitotoxicity BR Leavitt, JM van Raamsdonk, J Shehadeh, H Fernandes, Z Murphy, ... Journal of neurochemistry 96 (4), 1121-1129, 2006 | 263 | 2006 |
| Selective degeneration and nuclear localization of mutant huntingtin in the YAC128 mouse model of Huntington disease JM Van Raamsdonk, Z Murphy, EJ Slow, BR Leavitt, MR Hayden Human molecular genetics 14 (24), 3823-3835, 2005 | 238 | 2005 |
| Mitochondrial and cytoplasmic ROS have opposing effects on lifespan CE Schaar, DJ Dues, KK Spielbauer, E Machiela, JF Cooper, M Senchuk, ... PLoS genetics 11 (2), e1004972, 2015 | 232 | 2015 |
| Reactive Oxygen Species and Aging in Caenorhabditis elegans: Causal or Casual Relationship? JM Van Raamsdonk, S Hekimi Antioxidants & redox signaling 13 (12), 1911-1953, 2010 | 231 | 2010 |
| Loss of wild-type huntingtin influences motor dysfunction and survival in the YAC128 mouse model of Huntington disease JM Van Raamsdonk, J Pearson, DA Rogers, N Bissada, AW Vogl, ... Human molecular genetics 14 (10), 1379-1392, 2005 | 211 | 2005 |
| Modeling Parkinson’s Disease in C. elegans JF Cooper, JM Van Raamsdonk Journal of Parkinson's disease 8 (1), 17-32, 2018 | 183 | 2018 |
| Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration in experimental models of Parkinson’s disease A Ghosh, T Tyson, S George, EN Hildebrandt, JA Steiner, Z Madaj, ... Science translational medicine 8 (368), 368ra174-368ra174, 2016 | 169 | 2016 |
| Huntingtin inhibits caspase‐3 activation Y Zhang, BR Leavitt, JM van Raamsdonk, I Dragatsis, D Goldowitz, ... The EMBO journal 25 (24), 5896-5906, 2006 | 164 | 2006 |
| Body weight is modulated by levels of full-length huntingtin JM Van Raamsdonk, WT Gibson, J Pearson, Z Murphy, G Lu, BR Leavitt, ... Human molecular genetics 15 (9), 1513-1523, 2006 | 150 | 2006 |
| FUdR causes a twofold increase in the lifespan of the mitochondrial mutant gas-1 JM Van Raamsdonk, S Hekimi Mechanisms of ageing and development 132 (10), 519-521, 2011 | 148 | 2011 |
| Activation of DAF-16/FOXO by reactive oxygen species contributes to longevity in long-lived mitochondrial mutants in Caenorhabditis elegans MM Senchuk, DJ Dues, CE Schaar, BK Johnson, ZB Madaj, MJ Bowman, ... PLoS genetics 14 (3), e1007268, 2018 | 144 | 2018 |
| Phenotypic abnormalities in the YAC128 mouse model of Huntington disease are penetrant on multiple genetic backgrounds and modulated by strain JM Van Raamsdonk, M Metzler, E Slow, J Pearson, C Schwab, J Carroll, ... Neurobiology of disease 26 (1), 189-200, 2007 | 131 | 2007 |
| Testicular degeneration in Huntington disease JM Van Raamsdonk, Z Murphy, DM Selva, R Hamidizadeh, J Pearson, ... Neurobiology of disease 26 (3), 512-520, 2007 | 130 | 2007 |
| Decreased Energy Metabolism Extends Life Span in Caenorhabditis elegans Without Reducing Oxidative Damage JM Van Raamsdonk, Y Meng, D Camp, W Yang, X Jia, C Bénard, ... Genetics 185 (2), 559-571, 2010 | 129 | 2010 |
Michael HaydenKillam Professor, University of British ColumbiaVerified email at cmmt.ubc.ca