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Jonathan A Beagan
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On the existence and functionality of topologically associating domains
JA Beagan, JE Phillips-Cremins
Nature genetics 52 (1), 8-16, 2020
3612020
YY1 and CTCF orchestrate a 3D chromatin looping switch during early neural lineage commitment
JA Beagan, MT Duong, KR Titus, L Zhou, Z Cao, J Ma, CV Lachanski, ...
Genome research 27 (7), 1139-1152, 2017
2992017
Disease-associated short tandem repeats co-localize with chromatin domain boundaries
JH Sun, L Zhou, DJ Emerson, SA Phyo, KR Titus, W Gong, TG Gilgenast, ...
Cell 175 (1), 224-238. e15, 2018
2162018
Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons
EM Rocha, GA Smith, E Park, H Cao, E Brown, MA Hayes, J Beagan, ...
Neurobiology of disease 82, 495-503, 2015
1802015
Sustained systemic glucocerebrosidase inhibition induces brain α-synuclein aggregation, microglia and complement C1q activation in mice
EM Rocha, GA Smith, E Park, H Cao, AR Graham, E Brown, JR McLean, ...
Antioxidants & redox signaling 23 (6), 550-564, 2015
1502015
Three-dimensional genome restructuring across timescales of activity-induced neuronal gene expression
JA Beagan, ED Pastuzyn, LR Fernandez, MH Guo, K Feng, KR Titus, ...
Nature neuroscience 23 (6), 707-717, 2020
1462020
Local genome topology can exhibit an incompletely rewired 3D-folding state during somatic cell reprogramming
JA Beagan, TG Gilgenast, J Kim, Z Plona, HK Norton, G Hu, SC Hsu, ...
Cell stem cell 18 (5), 611-624, 2016
1332016
LADL: light-activated dynamic looping for endogenous gene expression control
JH Kim, M Rege, J Valeri, MC Dunagin, A Metzger, KR Titus, TG Gilgenast, ...
Nature methods 16 (7), 633-639, 2019
1312019
Widespread neuron-specific transgene expression in brain and spinal cord following synapsin promoter-driven AAV9 neonatal intracerebroventricular injection
JR McLean, GA Smith, EM Rocha, MA Hayes, JA Beagan, PJ Hallett, ...
Neuroscience letters 576, 73-78, 2014
1122014
Cohesin-dependence of neuronal gene expression relates to chromatin loop length
L Calderon, FD Weiss, JA Beagan, MS Oliveira, R Georgieva, YF Wang, ...
Elife 11, e76539, 2022
85*2022
A Nurr1 agonist causes neuroprotection in a Parkinson’s disease lesion model primed with the toll-like receptor 3 dsRNA inflammatory stimulant poly (I: C)
GA Smith, EM Rocha, T Rooney, P Barneoud, JR McLean, J Beagan, ...
PloS one 10 (3), e0121072, 2015
852015
Neuronal Yin Yang1 in the prefrontal cortex regulates transcriptional and behavioral responses to chronic stress in mice
DY Kwon, B Xu, P Hu, YT Zhao, JA Beagan, JH Nofziger, Y Cui, ...
Nature communications 13 (1), 55, 2022
232022
5C-ID: Increased resolution Chromosome-Conformation-Capture-Carbon-Copy with in situ 3C and double alternating primer design
JH Kim, KR Titus, W Gong, JA Beagan, Z Cao, JE Phillips-Cremins
Methods 142, 39-46, 2018
222018
ALS-associated peripherin spliced transcripts form distinct protein inclusions that are neuroprotective against oxidative stress
JR McLean, GA Smith, EM Rocha, TM Osborn, S Dib, MA Hayes, ...
Experimental Neurology 261, 217-229, 2014
152014
Increased motor neuron resilience by small molecule compounds that regulate IGF-II expression
TM Osborn, J Beagan, O Isacson
Neurobiology of Disease 110, 218-230, 2018
132018
CRISPR/Cas9 genome editing throws descriptive 3‐D genome folding studies for a loop
JA Beagan, JE Phillips‐Cremins
Wiley Interdisciplinary Reviews: Systems Biology and Medicine 8 (4), 286-299, 2016
42016
Specific configurations of electrical synapses filter sensory information to drive choices in behavior
A Almoril-Porras, AC Calvo, L Niu, J Beagan, JD Hawk, A Aljobeh, ...
bioRxiv, 2023
22023
Stress-induced epigenetic regulation of transcription in neocortical excitatory neurons drives depression-like behavior
DY Kwon, P Hu, YT Zhao, JA Beagan, JH Nofziger, Y Cui, B Xu, ...
bioRxiv, 2020.07. 06.190280, 2020
22020
Configuration of electrical synapses filters sensory information to drive behavioral choices
A Almoril-Porras, AC Calvo, L Niu, J Beagan, MD García, JD Hawk, ...
Cell 188 (1), 89-103. e13, 2025
2025
Elucidating the Regulatory Role of 3D Genome Folding During Neural Differentiation and Synaptic Activation
JA Beagan
University of Pennsylvania, 2020
2020
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