| DNA-demethylating agents target colorectal cancer cells by inducing viral mimicry by endogenous transcripts D Roulois, HL Yau, R Singhania, Y Wang, A Danesh, SY Shen, H Han, ... Cell 162 (5), 961-973, 2015 | 1416 | 2015 |
| Gene body methylation can alter gene expression and is a therapeutic target in cancer X Yang, H Han, DD De Carvalho, FD Lay, PA Jones, G Liang Cancer cell 26 (4), 577-590, 2014 | 1228 | 2014 |
| Epigenetic modifications as therapeutic targets TK Kelly, DD De Carvalho, PA Jones Nature biotechnology 28 (10), 1069-1078, 2010 | 938 | 2010 |
| Sensitive tumour detection and classification using plasma cell-free DNA methylomes SY Shen, R Singhania, G Fehringer, A Chakravarthy, MHA Roehrl, ... Nature 563 (7732), 579-583, 2018 | 810 | 2018 |
| LSD1 ablation stimulates anti-tumor immunity and enables checkpoint blockade W Sheng, MW LaFleur, TH Nguyen, S Chen, A Chakravarthy, JR Conway, ... Cell 174 (3), 549-563. e19, 2018 | 617 | 2018 |
| TGF-β-associated extracellular matrix genes link cancer-associated fibroblasts to immune evasion and immunotherapy failure A Chakravarthy, L Khan, NP Bensler, P Bose, DD De Carvalho Nature communications 9 (1), 4692, 2018 | 549 | 2018 |
| Epigenetic therapy in immune-oncology PA Jones, H Ohtani, A Chakravarthy, DD De Carvalho Nature Reviews Cancer 19 (3), 151-161, 2019 | 485 | 2019 |
| DNA methylation screening identifies driver epigenetic events of cancer cell survival DD De Carvalho, S Sharma, JS You, SF Su, PC Taberlay, TK Kelly, ... Cancer cell 21 (5), 655-667, 2012 | 338 | 2012 |
| A clinically applicable integrative molecular classification of meningiomas F Nassiri, J Liu, V Patil, Y Mamatjan, JZ Wang, R Hugh-White, AM Macklin, ... Nature 597 (7874), 119-125, 2021 | 321 | 2021 |
| Single-cell analysis reveals transcriptomic remodellings in distinct cell types that contribute to human prostate cancer progression S Chen, G Zhu, Y Yang, F Wang, YT Xiao, N Zhang, X Bian, Y Zhu, Y Yu, ... Nature cell biology 23 (1), 87-98, 2021 | 317 | 2021 |
| DNA methylation and cellular reprogramming DD De Carvalho, JS You, PA Jones Trends in cell biology 20 (10), 609-617, 2010 | 276 | 2010 |
| Detection of renal cell carcinoma using plasma and urine cell-free DNA methylomes PV Nuzzo, JE Berchuck, K Korthauer, S Spisak, AH Nassar, S Abou Alaiwi, ... Nature medicine 26 (7), 1041-1043, 2020 | 256 | 2020 |
| Integrated (epi)-genomic analyses identify subgroup-specific therapeutic targets in CNS rhabdoid tumors J Torchia, B Golbourn, S Feng, KC Ho, P Sin-Chan, A Vasiljevic, ... Cancer cell 30 (6), 891-908, 2016 | 252 | 2016 |
| Detection and discrimination of intracranial tumors using plasma cell-free DNA methylomes F Nassiri, A Chakravarthy, S Feng, SY Shen, R Nejad, JA Zuccato, ... Nature medicine 26 (7), 1044-1047, 2020 | 246 | 2020 |
| Mutant IDH1 downregulates ATM and alters DNA repair and sensitivity to DNA damage independent of TET2 S Inoue, WY Li, A Tseng, I Beerman, AJ Elia, SC Bendall, F Lemonnier, ... Cancer cell 30 (2), 337-348, 2016 | 226 | 2016 |
| Epigenetic therapy induces transcription of inverted SINEs and ADAR1 dependency P Mehdipour, SA Marhon, I Ettayebi, A Chakravarthy, A Hosseini, Y Wang, ... Nature 588 (7836), 169-173, 2020 | 219 | 2020 |
| Polycomb-repressed genes have permissive enhancers that initiate reprogramming PC Taberlay, TK Kelly, CC Liu, JS You, DD De Carvalho, TB Miranda, ... Cell 147 (6), 1283-1294, 2011 | 211 | 2011 |
| IL17 promotes mammary tumor progression by changing the behavior of tumor cells and eliciting tumorigenic neutrophils recruitment L Benevides, DM da Fonseca, PB Donate, DG Tiezzi, DD De Carvalho, ... Cancer research 75 (18), 3788-3799, 2015 | 208 | 2015 |
| Pervasive H3K27 acetylation leads to ERV expression and a therapeutic vulnerability in H3K27M gliomas B Krug, N De Jay, AS Harutyunyan, S Deshmukh, DM Marchione, ... Cancer cell 35 (5), 782-797. e8, 2019 | 197 | 2019 |
| Nucleolar RNA polymerase II drives ribosome biogenesis KJ Abraham, N Khosraviani, JNY Chan, A Gorthi, A Samman, DY Zhao, ... Nature 585 (7824), 298-302, 2020 | 194 | 2020 |
Scott V Bratman, MD PhDSenior Scientist (Principal Investigator), Princess Margaret Cancer Centre, University HealthVerified email at uhnresearch.ca
