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Steven G. Younkin
Steven G. Younkin
Professor of Neuroscience, Mayo Clinic
Verified email at mayo.edu
Title
Cited by
Cited by
Year
Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice
K Hsiao, P Chapman, S Nilsen, C Eckman, Y Harigaya, S Younkin, ...
Science 274 (5284), 99-103, 1996
55211996
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
JC Lambert, CA Ibrahim-Verbaas, D Harold, AC Naj, R Sims, ...
Nature genetics 45 (12), 1452-1458, 2013
46832013
Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to …
D Scheuner, C Eckman, M Jensen, X Song, M Citron, N Suzuki, TD Bird, ...
Nature medicine 2 (8), 864-870, 1996
36551996
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
D Harold, R Abraham, P Hollingworth, R Sims, A Gerrish, ML Hamshere, ...
Nature genetics 41 (10), 1088-1093, 2009
34412009
TREM2 Variants in Alzheimer's Disease
R Guerreiro, A Wojtas, J Bras, M Carrasquillo, E Rogaeva, E Majounie, ...
New England Journal of Medicine 368 (2), 117-127, 2013
33172013
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
BW Kunkle, B Grenier-Boley, R Sims, JC Bis, V Damotte, AC Naj, ...
Nature genetics 51 (3), 414-430, 2019
25782019
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
P Hollingworth, D Harold, R Sims, A Gerrish, JC Lambert, ...
Nature genetics 43 (5), 429-435, 2011
22872011
An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp717) Mutants
N Suzuki, TT Cheung, XD Cai, A Odaka, L Otvos Jr, C Eckman, TE Golde, ...
Science 264 (5163), 1336-1340, 1994
22641994
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease
AC Naj, G Jun, GW Beecham, LS Wang, BN Vardarajan, J Buros, ...
Nature genetics 43 (5), 436-441, 2011
22432011
Familial Alzheimer's disease–linked presenilin 1 variants elevate Aβ1–42/1–40 ratio in vitro and in vivo
DR Borchelt, G Thinakaran, CB Eckman, MK Lee, F Davenport, ...
Neuron 17 (5), 1005-1013, 1996
21371996
Increased amyloid-β42 (43) in brains of mice expressing mutant presenilin 1
K Duff, C Eckman, C Zehr, X Yu, CM Prada, J Perez-Tur, M Hutton, L Buee, ...
Nature 383 (6602), 710-713, 1996
20871996
Production of the Alzheimer amyloid β protein by normal proteolytic processing
M Shoji, TE Golde, J Ghiso, TT Cheung, S Estus, LM Shaffer, XD Cai, ...
Science 258 (5079), 126-129, 1992
19781992
Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: evidence for augmentation of a 42-specific γ secretase
JL Jankowsky, DJ Fadale, J Anderson, GM Xu, V Gonzales, NA Jenkins, ...
Human molecular genetics 13 (2), 159-170, 2004
18392004
The'Arctic'APP mutation (E693G) causes Alzheimer's disease by enhanced Aβ protofibril formation
C Nilsberth, A Westlind-Danielsson, CB Eckman, MM Condron, ...
Nature neuroscience 4 (9), 887-893, 2001
15852001
Release of excess amyloid β protein from a mutant amyloid β protein precursor
XD Cai, TE Golde, SG Younkin
Science 259 (5094), 514-516, 1993
14891993
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease
E Rogaeva, Y Meng, JH Lee, Y Gu, T Kawarai, F Zou, T Katayama, ...
Nature genetics 39 (2), 168-177, 2007
14472007
Age-dependent changes in brain, CSF, and plasma amyloid β protein in the Tg2576 transgenic mouse model of Alzheimer's disease
T Kawarabayashi, LH Younkin, TC Saido, M Shoji, KH Ashe, SG Younkin
Journal of neuroscience 21 (2), 372-381, 2001
13002001
Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice
PF Chapman, GL White, MW Jones, D Cooper-Blacketer, VJ Marshall, ...
Nature neuroscience 2 (3), 271-276, 1999
12071999
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
R Sims, SJ Van Der Lee, AC Naj, C Bellenguez, N Badarinarayan, ...
Nature genetics 49 (9), 1373-1384, 2017
9832017
Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci
PL De Jager, G Srivastava, K Lunnon, J Burgess, LC Schalkwyk, L Yu, ...
Nature neuroscience 17 (9), 1156-1163, 2014
9742014
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