| Expanding the medicinal chemistry synthetic toolbox J Boström, DG Brown, RJ Young, GM Keserü Nature Reviews Drug Discovery 17 (10), 709-727, 2018 | 647 | 2018 |
| The impact of aromatic ring count on compound developability: further insights by examining carbo-and hetero-aromatic and-aliphatic ring types TJ Ritchie, SJF Macdonald, RJ Young, SD Pickett Drug discovery today 16 (3-4), 164-171, 2011 | 434 | 2011 |
| Fueling open‐source drug discovery: 177 small‐molecule leads against tuberculosis L Ballell, RH Bates, RJ Young, D Alvarez‐Gomez, E Alvarez‐Ruiz, ... ChemMedChem 8 (2), 313-321, 2013 | 373 | 2013 |
| Getting physical in drug discovery II: the impact of chromatographic hydrophobicity measurements and aromaticity RJ Young, DVS Green, CN Luscombe, AP Hill Drug discovery today 16 (17-18), 822-830, 2011 | 351 | 2011 |
| Getting physical in drug discovery: a contemporary perspective on solubility and hydrophobicity AP Hill, RJ Young Drug discovery today 15 (15-16), 648-655, 2010 | 310 | 2010 |
| New small-molecule synthetic antimycobacterials L Ballell, RA Field, K Duncan, RJ Young Antimicrobial agents and chemotherapy 49 (6), 2153-2163, 2005 | 252 | 2005 |
| New thiopyrazolo [3, 4-d] pyrimidine derivatives as anti-mycobacterial agents L Ballell, RA Field, GAC Chung, RJ Young Bioorganic & medicinal chemistry letters 17 (6), 1736-1740, 2007 | 157 | 2007 |
| Molecular property design: does everyone get it? PD Leeson, RJ Young ACS medicinal chemistry letters 6 (7), 722-725, 2015 | 153 | 2015 |
| An Electrostatic Gauche Effect in β‐Fluoro‐ and β‐Hydroxy‐N‐ethylpyridinium Cations NEJ Gooseman, D O'Hagan, MJG Peach, AMZ Slawin, DJ Tozer, ... Angewandte Chemie International Edition 46 (31), 5904-5908, 2007 | 114 | 2007 |
| Mapping the efficiency and physicochemical trajectories of successful optimizations RJ Young, PD Leeson Journal of medicinal chemistry 61 (15), 6421-6467, 2018 | 111 | 2018 |
| Inhibition of inducible nitric oxide synthase by acetamidine derivatives of hetero-substituted lysine and homolysine RJ Young, RM Beams, K Carter, HAR Clark, DM Coe, CL Chambers, ... Bioorganic & medicinal chemistry letters 10 (6), 597-600, 2000 | 106 | 2000 |
| Facts, Patterns and Principles in Drug Discovery: appraising the Rule of 5 with measured physicochemical data. CP Tinworth, RJ Young Journal of Medicinal Chemistry, 2020 | 100 | 2020 |
| Design, synthesis, and evaluation of new thiadiazole-based direct inhibitors of enoyl acyl carrier protein reductase (InhA) for the treatment of tuberculosis R Šink, I Sosič, M Živec, R Fernandez-Menendez, S Turk, S Pajk, ... Journal of medicinal chemistry 58 (2), 613-624, 2015 | 84 | 2015 |
| The Time and Place for Nature in Drug Discovery RJ Young, SL Flitsch, M Grigalunas, PD Leeson, RJ Quinn, NJ Turner, ... JACS Au 2 (11), 2400-2416, 2022 | 77 | 2022 |
| Application of Biocatalysis to on‐DNA Carbohydrate Library Synthesis B Thomas, X Lu, WR Birmingham, K Huang, P Both, JE Reyes Martinez, ... ChemBioChem 18 (9), 858-863, 2017 | 74 | 2017 |
| Whole Cell Target Engagement Identifies Novel Inhibitors of Mycobacterium tuberculosis Decaprenylphosphoryl-β-d-ribose Oxidase SM Batt, M Cacho Izquierdo, J Castro Pichel, CJ Stubbs, ... ACS Infectious Diseases 1 (12), 615-626, 2015 | 71 | 2015 |
| Synthesis and antiviral evaluation of enantiomeric 2′, 3′-dideoxy-and 2′, 3′-didehydro-2′, 3′-dideoxy-4′-thionucleosides RJ Young, S Shaw-Ponter, JB Thomson, JA Miller, JG Cumming, ... Bioorganic & Medicinal Chemistry Letters 5 (22), 2599-2604, 1995 | 71 | 1995 |
| A new ‘golden age’for the antitubercular target InhA K Rožman, I Sosič, R Fernandez, RJ Young, A Mendoza, S Gobec, ... Drug discovery today 22 (3), 492-502, 2017 | 70 | 2017 |
| Factor Xa inhibitors: S1 binding interactions of a series of N-{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl} sulfonamides C Chan, AD Borthwick, D Brown, CL Burns-Kurtis, M Campbell, ... Journal of medicinal chemistry 50 (7), 1546-1557, 2007 | 57 | 2007 |
| Release of 50 new, drug-like compounds and their computational target predictions for open source anti-tubercular drug discovery MJ Rebollo-Lopez, J Lelièvre, D Alvarez-Gomez, J Castro-Pichel, ... PloS one 10 (12), e0142293, 2015 | 50 | 2015 |
Rob FieldPVC Science, UEA and Iceni GlycoscienceVerified email at uea.ac.uk