| Minimum information about a biosynthetic gene cluster MH Medema, R Kottmann, P Yilmaz, M Cummings, JB Biggins, K Blin, ... Nature chemical biology 11 (9), 625-631, 2015 | 939 | 2015 |
| Artificial intelligence for natural product drug discovery MW Mullowney, KR Duncan, SS Elsayed, N Garg, JJJ van der Hooft, ... Nature Reviews Drug Discovery 22 (11), 895-916, 2023 | 145 | 2023 |
| Antibiotics from Gram-negative bacteria: a comprehensive overview and selected biosynthetic highlights J Masschelein, M Jenner, GL Challis Natural product reports 34 (7), 712-783, 2017 | 128 | 2017 |
| Discovery and Biosynthesis of Gladiolin: A Burkholderia gladioli Antibiotic with Promising Activity against Mycobacterium tuberculosis L Song, M Jenner, J Masschelein, C Jones, MJ Bull, SR Harris, ... Journal of the American Chemical Society 139 (23), 7974-7981, 2017 | 105 | 2017 |
| Isolation and purification of a new kalimantacin/batumin-related polyketide antibiotic and elucidation of its biosynthesis gene cluster W Mattheus, LJ Gao, P Herdewijn, B Landuyt, J Verhaegen, ... Chemistry & biology 17 (2), 149-159, 2010 | 103 | 2010 |
| A PKS/NRPS/FAS hybrid gene cluster from Serratia plymuthica RVH1 encoding the biosynthesis of three broad spectrum, zeamine-related antibiotics J Masschelein, W Mattheus, LJ Gao, P Moons, R Van Houdt, ... PLoS One 8 (1), e54143, 2013 | 91 | 2013 |
| A conserved motif flags acyl carrier proteins for β-branching in polyketide synthesis AS Haines, X Dong, Z Song, R Farmer, C Williams, J Hothersall, ... Nature chemical biology 9 (11), 685-692, 2013 | 81 | 2013 |
| Thioester reduction and aldehyde transamination are universal steps in actinobacterial polyketide alkaloid biosynthesis GLC Ufedo R. Awodi1, Jade L. Ronan1, Joleen Masschelein1, Emmanuel L.C. de ... Chemical Science, 2016 | 59* | 2016 |
| Beyond peptide bond formation: the versatile role of condensation domains in natural product biosynthesis S Dekimpe, J Masschelein Natural product reports 38 (10), 1910-1937, 2021 | 55 | 2021 |
| Structural basis for chain release from the enacyloxin polyketide synthase S Kosol, A Gallo, D Griffiths, TR Valentic, J Masschelein, M Jenner, ... Nature chemistry 11 (10), 913-923, 2019 | 54 | 2019 |
| An unusual Burkholderia gladioli double chain-initiating nonribosomal peptide synthetase assembles ‘fungal’ icosalide antibiotics M Jenner, X Jian, Y Dashti, J Masschelein, C Hobson, D Roberts, C Jones, ... Chemical Science 10 (DOI: 10.1039/C8SC04897E), 2019 | 45 | 2019 |
| The kalimantacin/batumin biosynthesis operon encodes a self-resistance isoform of the FabI bacterial target W Mattheus, J Masschelein, LJ Gao, P Herdewijn, B Landuyt, G Volckaert, ... Chemistry & Biology 17 (10), 1067-1071, 2010 | 43 | 2010 |
| A combination of polyunsaturated fatty acid, nonribosomal peptide and polyketide biosynthetic machinery is used to assemble the zeamine antibiotics J Masschelein, C Clauwers, UR Awodi, K Stalmans, W Vermaelen, ... Chemical science 6 (2), 923-929, 2015 | 42 | 2015 |
| A dual transacylation mechanism for polyketide synthase chain release in enacyloxin antibiotic biosynthesis J Masschelein, PK Sydor, C Hobson, R Howe, C Jones, DM Roberts, ... Nature chemistry 11 (10), 906-912, 2019 | 39 | 2019 |
| The zeamine antibiotics affect the integrity of bacterial membranes J Masschelein, C Clauwers, K Stalmans, K Nuyts, W De Borggraeve, ... Applied and environmental microbiology 81 (3), 1139-1146, 2015 | 37 | 2015 |
| The Kalimantacin Polyketide Antibiotics Inhibit Fatty Acid Biosynthesis in Staphylococcus aureus by Targeting the Enoyl‐Acyl Carrier Protein Binding Site of FabI CD Fage, T Lathouwers, M Vanmeert, LJ Gao, K Vrancken, EM Lammens, ... Angewandte Chemie International Edition 59 (26), 10549-10556, 2020 | 34 | 2020 |
| Genomics‐Driven Discovery of a Novel Glutarimide Antibiotic from Burkholderia gladioli Reveals an Unusual Polyketide Synthase Chain Release Mechanism IT Nakou, M Jenner, Y Dashti, I Romero‐Canelón, J Masschelein, ... Angewandte Chemie 132 (51), 23345-23353, 2020 | 25 | 2020 |
| Pentamycin Biosynthesis in Philippine Streptomyces sp. S816: Cytochrome P450-Catalyzed Installation of the C-14 Hydroxyl Group S Zhou, L Song, J Masschelein, FAM Sumang, IA Papa, TO Zulaybar, ... ACS Chemical Biology 14 (6), 1305-1309, 2019 | 25 | 2019 |
| Elucidation of the relative and absolute stereochemistry of the kalimantacin/batumin antibiotics IRG Thistlethwaite, FM Bull, C Cui, PD Walker, SS Gao, L Wang, Z Song, ... Chemical Science 8 (9), 6196-6201, 2017 | 21 | 2017 |
| Combinatorial optimization of gene expression through recombinase-mediated promoter and terminator shuffling in yeast C Cautereels, J Smets, P Bircham, D De Ruysscher, A Zimmermann, ... Nature communications 15 (1), 1112, 2024 | 11 | 2024 |