New paradigms in chemokine receptor signal transduction: Moving beyond the two-site model AB Kleist, AE Getschman, JJ Ziarek, AM Nevins, PA Gauthier, A Chevigné, ... Biochemical pharmacology 114, 53-68, 2016 | 151 | 2016 |
Divergent transducer-specific molecular efficacies generate biased agonism at a G protein-coupled receptor (GPCR) RT Strachan, J Sun, DH Rominger, JD Violin, S Ahn, ARB Thomsen, ... Journal of Biological Chemistry 289 (20), 14211-14224, 2014 | 137 | 2014 |
Conformation guides molecular efficacy in docking screens of activated β-2 adrenergic G protein coupled receptor DR Weiss, SK Ahn, MF Sassano, A Kleist, X Zhu, R Strachan, BL Roth, ... ACS chemical biology 8 (5), 1018-1026, 2013 | 119 | 2013 |
Structural basis for chemokine recognition by a G protein–coupled receptor and implications for receptor activation JJ Ziarek, AB Kleist, N London, B Raveh, N Montpas, J Bonneterre, ... Science signaling 10 (471), eaah5756, 2017 | 96 | 2017 |
Evolution of fold switching in a metamorphic protein AF Dishman, RC Tyler, JC Fox, AB Kleist, KE Prehoda, MM Babu, ... Science 371 (6524), 86-90, 2021 | 79 | 2021 |
Integrated Genomic Analysis Identifies UBTF Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid Leukemia M Umeda, J Ma, BJ Huang, K Hagiwara, T Westover, S Abdelhamed, ... Blood cancer discovery 3 (3), 194-207, 2022 | 74 | 2022 |
Different contributions of chemokine N‐terminal features attest to a different ligand binding mode and a bias towards activation of ACKR3/CXCR7 compared with CXCR4 and CXCR3 M Szpakowska, AM Nevins, M Meyrath, D Rhainds, T D'huys, ... British journal of pharmacology 175 (9), 1419-1438, 2018 | 61 | 2018 |
CCL22 mutations drive natural killer cell lymphoproliferative disease by deregulating microenvironmental crosstalk C Baer, S Kimura, MS Rana, AB Kleist, T Flerlage, DJ Feith, P Chockley, ... Nature genetics 54 (5), 637-648, 2022 | 33 | 2022 |
Decoding the chemotactic signal MA Thomas, AB Kleist, BF Volkman Journal of leukocyte biology 104 (2), 359-374, 2018 | 33 | 2018 |
Conformational selection guides β-arrestin recruitment at a biased G protein–coupled receptor AB Kleist, S Jenjak, A Sente, LJ Laskowski, M Szpakowska, MM Calkins, ... Science 377 (6602), 222-228, 2022 | 23 | 2022 |
Solution NMR spectroscopy of GPCRs: Residue-specific labeling strategies with a focus on 13C-methyl methionine labeling of the atypical chemokine receptor ACKR3 AB Kleist, F Peterson, RC Tyler, M Gustavsson, TM Handel, BF Volkman Methods in cell biology 149, 259-288, 2019 | 12 | 2019 |
324 Allosteric pathways of CFTR activation reveal mechanistic insights into modulator-resistant variants A Kleist, N Sharma, H Li, G Lin, S Jalloh, K Raraigh, M Babu, D Sheppard, ... Journal of Cystic Fibrosis 22, S162, 2023 | | 2023 |
Signal Discrimination and Signal Transduction at Chemokine G Protein-Coupled Receptors AB Kleist The Medical College of Wisconsin, 2019 | | 2019 |