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Andrew Kleist
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New paradigms in chemokine receptor signal transduction: Moving beyond the two-site model
AB Kleist, AE Getschman, JJ Ziarek, AM Nevins, PA Gauthier, A Chevigné, ...
Biochemical pharmacology 114, 53-68, 2016
1512016
Divergent transducer-specific molecular efficacies generate biased agonism at a G protein-coupled receptor (GPCR)
RT Strachan, J Sun, DH Rominger, JD Violin, S Ahn, ARB Thomsen, ...
Journal of Biological Chemistry 289 (20), 14211-14224, 2014
1372014
Conformation guides molecular efficacy in docking screens of activated β-2 adrenergic G protein coupled receptor
DR Weiss, SK Ahn, MF Sassano, A Kleist, X Zhu, R Strachan, BL Roth, ...
ACS chemical biology 8 (5), 1018-1026, 2013
1192013
Structural basis for chemokine recognition by a G protein–coupled receptor and implications for receptor activation
JJ Ziarek, AB Kleist, N London, B Raveh, N Montpas, J Bonneterre, ...
Science signaling 10 (471), eaah5756, 2017
962017
Evolution of fold switching in a metamorphic protein
AF Dishman, RC Tyler, JC Fox, AB Kleist, KE Prehoda, MM Babu, ...
Science 371 (6524), 86-90, 2021
792021
Integrated Genomic Analysis Identifies UBTF Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid Leukemia
M Umeda, J Ma, BJ Huang, K Hagiwara, T Westover, S Abdelhamed, ...
Blood cancer discovery 3 (3), 194-207, 2022
742022
Different contributions of chemokine N‐terminal features attest to a different ligand binding mode and a bias towards activation of ACKR3/CXCR7 compared with CXCR4 and CXCR3
M Szpakowska, AM Nevins, M Meyrath, D Rhainds, T D'huys, ...
British journal of pharmacology 175 (9), 1419-1438, 2018
612018
CCL22 mutations drive natural killer cell lymphoproliferative disease by deregulating microenvironmental crosstalk
C Baer, S Kimura, MS Rana, AB Kleist, T Flerlage, DJ Feith, P Chockley, ...
Nature genetics 54 (5), 637-648, 2022
332022
Decoding the chemotactic signal
MA Thomas, AB Kleist, BF Volkman
Journal of leukocyte biology 104 (2), 359-374, 2018
332018
Conformational selection guides β-arrestin recruitment at a biased G protein–coupled receptor
AB Kleist, S Jenjak, A Sente, LJ Laskowski, M Szpakowska, MM Calkins, ...
Science 377 (6602), 222-228, 2022
232022
Solution NMR spectroscopy of GPCRs: Residue-specific labeling strategies with a focus on 13C-methyl methionine labeling of the atypical chemokine receptor ACKR3
AB Kleist, F Peterson, RC Tyler, M Gustavsson, TM Handel, BF Volkman
Methods in cell biology 149, 259-288, 2019
122019
324 Allosteric pathways of CFTR activation reveal mechanistic insights into modulator-resistant variants
A Kleist, N Sharma, H Li, G Lin, S Jalloh, K Raraigh, M Babu, D Sheppard, ...
Journal of Cystic Fibrosis 22, S162, 2023
2023
Signal Discrimination and Signal Transduction at Chemokine G Protein-Coupled Receptors
AB Kleist
The Medical College of Wisconsin, 2019
2019
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