| Slow freezing process design for human induced pluripotent stem cells by modeling intracontainer variation Y Hayashi, I Horiguchi, M Kino-oka, H Sugiyama Computers & Chemical Engineering 132, 106597, 2020 | 23 | 2020 |
| Model-based assessment of temperature profiles in slow freezing for human induced pluripotent stem cells Y Hayashi, I Horiguchi, M Kino-oka, H Sugiyama Computers & Chemical Engineering 144, 107150, 2021 | 19 | 2021 |
| A heterothermic kinetic model of hydrogen absorption in metals with subsurface transport S Ono, T Uchikoshi, Y Hayashi, Y Kitagawa, G Yeh, E Yamaguchi, ... Metals 9, 1131, 2019 | 15 | 2019 |
| A Dynamic and Probabilistic Design Space Determination Method for Mesenchymal Stem Cell Cultivation Processes K Hirono, I A. Udugama, Y Hayashi, M Kino-oka, H Sugiyama Industrial & Engineering Chemistry Research 61, 7009-7019, 2022 | 11 | 2022 |
| Hybrid-model-based design of fill-freeze-thaw processes for human induced pluripotent stem cells considering productivity and quality Y Hayashi, M Kino-oka, H Sugiyama Computers & Chemical Engineering 156, 107566, 2022 | 11 | 2022 |
| Computational screening of cryoprotective agents for regenerative medical products using quantum chemistry and molecular dynamics simulations Y Hayashi, Y Nakajima, H Sugiyama Cryobiology 100, 101-109, 2021 | 8 | 2021 |
| Roles of mechanistic, data-driven, and hybrid modeling approaches for pharmaceutical process design and operation MR Gaddem, J Kim, K Matsunami, Y Hayashi, S Badr, H Sugiyama Current Opinion in Chemical Engineering 44, 101019, 2024 | 7 | 2024 |
| The role of process systems engineering in applying quality by design (QbD) in mesenchymal stem cell production IA Udugama, S Badr, K Hirono, BX Scholz, Y Hayashi, M Kino-oka, ... Computers & Chemical Engineering 172, 108144, 2023 | 6 | 2023 |
| Hybrid Modeling of an Active Pharmaceutical Ingredient Flow Synthesis in a Ring-Opening Reaction of an Epoxide with a Grignard Reagent J Kim, Y Hayashi, S Badr, K Okamoto, T Hakogi, H Furukawa, ... Industrial & Engineering Chemistry Research 62 (43), 17824-17834, 2023 | 5 | 2023 |
| Impact of solvent selection on batch and flow syntheses for heterogeneous hydrogenation in drug substance manufacturing: A model-based analysis J Kim, Y Hayashi, S Badr, H Nakanishi, H Sugiyama Chemical Engineering Research and Design 189, 156-166, 2023 | 5 | 2023 |
| A CFD model-based design of seeding processes for two-dimensional mesenchymal stem cell cultivation BX Scholz, Y Hayashi, IA Udugama, M Kino-oka, H Sugiyama Computers & Chemical Engineering 171, 108157, 2023 | 3 | 2023 |
| Mechanistic insights into amination via nucleophilic aromatic substitution J Kim, Y Hayashi, S Badr, K Okamoto, T Hakogi, H Furukawa, ... Reaction Chemistry & Engineering 8, 2060-2070, 2023 | 3 | 2023 |
| Kinetic Study and Model-Based Design Space Determination for a Drug Substance Flow Synthesis Using an Amination Reaction via Nucleophilic Aromatic Substitution J Kim, Y Hayashi, S Badr, K Okamoto, T Hakogi, H Furukawa, ... Organic Process Research & Development 28 (5), 1793-1805, 2024 | 2 | 2024 |
| A multilayered approach to scale-up forced convection-based freezing of human induced pluripotent stem cells BX Scholz, Y Hayashi, IA Udugama, M Kino-oka, H Sugiyama Computers & Chemical Engineering 163, 107851, 2022 | 2 | 2022 |
| An agent-based model for cost-effectiveness analysis in the manufacture of allogeneic human induced pluripotent cells in Japan Y Hayashi, K Oishi, H Sugiyama Computer Aided Chemical Engineering 49, 2203-2208, 2022 | 2 | 2022 |
| Image‐based hybrid model incorporating initial spatial distribution for mesenchymal stem cell cultivation process design K Hirono, Y Hayashi, I A. Udugama, Y Takemoto, R Kato, M Kino‐oka, ... AIChE Journal, e18452, 2024 | 1 | 2024 |
| A Comprehensive Design Approach for Injectable Manufacturing Processes considering New Technologies and Operational Aspects M Yamada, S Badr, Y Hayashi, K Zenitani, K Kubota, H Nakanishi, ... Journal of Chemical Engineering of Japan 56 (1), 2201310, 2023 | 1 | 2023 |
| Development of concentration prediction models for personalized tablet manufacturing using near-infrared spectroscopy Y Hayashi, S Okazaki, K Matsunami, K Tanabe, T Nagato, H Sugiyama Chemical Engineering Research and Design 199, 507-514, 2023 | 1 | 2023 |
| A CFD-model-based approach to continuous freezing process design for human induced pluripotent stem cells Y Hayashi, BX Scholz, H Sugiyama Computer Aided Chemical Engineering 52, 65-70, 2023 | 1 | 2023 |
| Cost-effectiveness analysis in the manufacture of allogeneic human induced pluripotent cells in Japan by agent-based modeling Y Hayashi, K Oishi, H Sugiyama Chemical Engineering Research and Design 182, 172-182, 2022 | 1 | 2022 |
Hirokazu SugiyamaThe University of TokyoVerified email at chemsys.t.u-tokyo.ac.jp
