| Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism H Zhao, L Yang, J Baddour, A Achreja, V Bernard, T Moss, JC Marini, ... elife 5, e10250, 2016 | 899 | 2016 |
| Glutaminolysis: a hallmark of cancer metabolism L Yang, S Venneti, D Nagrath Annual review of biomedical engineering 19 (1), 163-194, 2017 | 817 | 2017 |
| Targeting stromal glutamine synthetase in tumors disrupts tumor microenvironment-regulated cancer cell growth L Yang, A Achreja, TL Yeung, LS Mangala, D Jiang, C Han, J Baddour, ... Cell metabolism 24 (5), 685-700, 2016 | 408 | 2016 |
| Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer L Yang, T Moss, LS Mangala, J Marini, H Zhao, S Wahlig, G Armaiz‐Pena, ... Molecular systems biology 10 (5), 728, 2014 | 374 | 2014 |
| Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer P Dey, J Baddour, F Muller, CC Wu, H Wang, WT Liao, Z Lan, A Chen, ... Nature 542 (7639), 119-123, 2017 | 281 | 2017 |
| Quantitative fluxomics of circulating metabolites S Hui, AJ Cowan, X Zeng, L Yang, T TeSlaa, X Li, C Bartman, Z Zhang, ... Cell metabolism 32 (4), 676-688. e4, 2020 | 231 | 2020 |
| Slow TCA flux and ATP production in primary solid tumours but not metastases CR Bartman, DR Weilandt, Y Shen, WD Lee, Y Han, T TeSlaa, ... Nature 614 (7947), 349-357, 2023 | 179 | 2023 |
| Serine catabolism feeds NADH when respiration is impaired L Yang, JCG Canaveras, Z Chen, L Wang, L Liang, C Jang, JA Mayr, ... Cell metabolism 31 (4), 809-821. e6, 2020 | 171 | 2020 |
| Lactate-mediated epigenetic reprogramming regulates formation of human pancreatic cancer-associated fibroblasts TD Bhagat, D Von Ahrens, M Dawlaty, Y Zou, J Baddour, A Achreja, ... Elife 8, e50663, 2019 | 143 | 2019 |
| The glucose‐deprivation network counteracts lapatinib‐induced toxicity in resistant ErbB2‐positive breast cancer cells K Komurov, JT Tseng, M Muller, EG Seviour, TJ Moss, L Yang, D Nagrath, ... Molecular systems biology 8 (1), 596, 2012 | 131 | 2012 |
| Pyruvate uptake is increased in highly invasive ovarian cancer cells under anoikis conditions for anaplerosis, mitochondrial function, and migration CA Caneba, N Bellance, L Yang, L Pabst, D Nagrath American Journal of Physiology-Endocrinology and Metabolism 303 (8), E1036-E1052, 2012 | 117 | 2012 |
| Amplification of USP13 drives ovarian cancer metabolism C Han, L Yang, HH Choi, J Baddour, A Achreja, Y Liu, Y Li, J Li, G Wan, ... Nature communications 7 (1), 13525, 2016 | 113 | 2016 |
| Spatially resolved isotope tracing reveals tissue metabolic activity L Wang, X Xing, X Zeng, SRE Jackson, T TeSlaa, O Al-Dalahmah, ... Nature methods 19 (2), 223-230, 2022 | 110 | 2022 |
| Peak annotation and verification engine for untargeted LC–MS metabolomics L Wang, X Xing, L Chen, L Yang, X Su, H Rabitz, W Lu, JD Rabinowitz Analytical chemistry 91 (3), 1838-1846, 2018 | 101 | 2018 |
| Myeloid-derived itaconate suppresses cytotoxic CD8+ T cells and promotes tumour growth H Zhao, D Teng, L Yang, X Xu, J Chen, T Jiang, AY Feng, Y Zhang, ... Nature metabolism 4 (12), 1660-1673, 2022 | 100 | 2022 |
| Nitric oxide is a positive regulator of the Warburg effect in ovarian cancer cells CA Caneba, L Yang, J Baddour, R Curtis, J Win, S Hartig, J Marini, ... Cell death & disease 5 (6), e1302-e1302, 2014 | 98 | 2014 |
| Mutant Kras-and p16-regulated NOX4 activation overcomes metabolic checkpoints in development of pancreatic ductal adenocarcinoma HQ Ju, H Ying, T Tian, J Ling, J Fu, Y Lu, M Wu, L Yang, A Achreja, ... Nature communications 8 (1), 14437, 2017 | 86 | 2017 |
| Role of Increased n-acetylaspartate Levels in Cancer B Zand, RA Previs, NM Zacharias, R Rupaimoole, T Mitamura, ... Journal of the National Cancer Institute 108 (6), djv426, 2016 | 83 | 2016 |
| Exo-MFA–a 13C metabolic flux analysis framework to dissect tumor microenvironment-secreted exosome contributions towards cancer cell metabolism A Achreja, H Zhao, L Yang, TH Yun, J Marini, D Nagrath Metabolic engineering 43, 156-172, 2017 | 76 | 2017 |
| Ketogenic diet and chemotherapy combine to disrupt pancreatic cancer metabolism and growth L Yang, T TeSlaa, S Ng, M Nofal, L Wang, T Lan, X Zeng, A Cowan, ... Med 3 (2), 119-136. e8, 2022 | 74 | 2022 |
Deepak NagrathDepartment of Biomedical Engineering, University of MichiganVerified email at umich.edu