| Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin RK Graham, Y Deng, EJ Slow, B Haigh, N Bissada, G Lu, J Pearson, ... Cell 125 (6), 1179-1191, 2006 | 822 | 2006 |
| Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease MM Zeron, O Hansson, N Chen, CL Wellington, BR Leavitt, P Brundin, ... Neuron 33 (6), 849-860, 2002 | 748 | 2002 |
| Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract CL Wellington, LM Ellerby, AS Hackam, RL Margolis, MA Trifiro, ... Journal of Biological Chemistry 273 (15), 9158-9167, 1998 | 737 | 1998 |
| Vascular contributions to cognitive impairment and dementia including Alzheimer's disease HM Snyder, RA Corriveau, S Craft, JE Faber, SM Greenberg, D Knopman, ... Alzheimer's & Dementia 11 (6), 710-717, 2015 | 671 | 2015 |
| Vascular dysfunction—the disregarded partner of Alzheimer's disease MD Sweeney, A Montagne, AP Sagare, DA Nation, LS Schneider, ... Alzheimer's & Dementia 15 (1), 158-167, 2019 | 660 | 2019 |
| Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1, 4, 5) triphosphate receptor type 1 TS Tang, H Tu, EYW Chan, A Maximov, Z Wang, CL Wellington, ... Neuron 39 (2), 227-239, 2003 | 623 | 2003 |
| Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates D Martindale, A Hackam, A Wieczorek, L Ellerby, C Wellington, ... Nature genetics 18 (2), 150-154, 1998 | 595 | 1998 |
| Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease CL Wellington, LM Ellerby, CA Gutekunst, D Rogers, S Warby, ... Journal of Neuroscience 22 (18), 7862-7872, 2002 | 513 | 2002 |
| Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells CL Wellington, L Ellerby, J Savill, S Roy, B Leavitt, E Cattaneo, A Hackam, ... Journal of Biological Chemistry 275 (26), 19831-19838, 2000 | 479 | 2000 |
| HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain MA Kalchman, HB Koide, K McCutcheon, RK Graham, K Nichol, ... Nature genetics 16 (1), 44-53, 1997 | 477 | 1997 |
| Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease SE Wahrle, H Jiang, M Parsadanian, J Kim, A Li, A Knoten, S Jain, ... The Journal of clinical investigation 118 (2), 671-682, 2008 | 458 | 2008 |
| Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain V Hirsch-Reinshagen, S Zhou, BL Burgess, L Bernier, SA McIsaac, ... Journal of Biological Chemistry 279 (39), 41197-41207, 2004 | 451 | 2004 |
| The influence of huntingtin protein size on nuclear localization and cellular toxicity AS Hackam, R Singaraja, CL Wellington, M Metzler, K McCutcheon, ... The Journal of cell biology 141 (5), 1097-1105, 1998 | 430 | 1998 |
| Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus J Gafni, E Hermel, JE Young, CL Wellington, MR Hayden, LM Ellerby Journal of Biological Chemistry 279 (19), 20211-20220, 2004 | 411 | 2004 |
| White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities J Alber, S Alladi, HJ Bae, DA Barton, LA Beckett, JM Bell, SE Berman, ... Alzheimer's & Dementia: Translational Research & Clinical Interventions 5 …, 2019 | 405 | 2019 |
| ABCA1 mRNA and protein distribution patterns predict multiple different roles and levels of regulation CL Wellington, EKY Walker, A Suarez, A Kwok, N Bissada, YZ Yang, ... Laboratory investigation 82 (3), 273-283, 2002 | 343 | 2002 |
| Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease E Hermel, J Gafni, SS Propp, BR Leavitt, CL Wellington, JE Young, ... Cell Death & Differentiation 11 (4), 424-438, 2004 | 312 | 2004 |
| 24 (S)-hydroxycholesterol participates in a liver X receptor-controlled pathway in astrocytes that regulates apolipoprotein E-mediated cholesterol efflux K Abildayeva, PJ Jansen, V Hirsch-Reinshagen, VW Bloks, AHF Bakker, ... Journal of Biological Chemistry 281 (18), 12799-12808, 2006 | 296 | 2006 |
| The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease V Hirsch-Reinshagen, LF Maia, BL Burgess, JF Blain, KE Naus, ... Journal of Biological Chemistry 280 (52), 43243-43256, 2005 | 293 | 2005 |
| Expanded polyglutamines in Caenorhabditis elegans cause axonal abnormalities and severe dysfunction of PLM mechanosensory neurons without cell death JA Parker, JB Connolly, C Wellington, M Hayden, J Dausset, C Neri Proceedings of the National Academy of Sciences 98 (23), 13318-13323, 2001 | 289 | 2001 |
