| Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4 Z Skrott, M Mistrik, KK Andersen, S Friis, D Majera, J Gursky, T Ozdian, ... Nature 552 (7684), 194-199, 2017 | 708 | 2017 |
| The Hsp90 chaperone machinery: conformational dynamics and regulation by co-chaperones J Li, J Soroka, J Buchner Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1823 (3), 624-635, 2012 | 629 | 2012 |
| Structure, function and regulation of the hsp90 machinery J Buchner, J Li Biomedical journal 36 (3), 106, 2013 | 510 | 2013 |
| Mixed Hsp90–cochaperone complexes are important for the progression of the reaction cycle J Li, K Richter, J Buchner Nature structural & molecular biology 18 (1), 61-66, 2011 | 207 | 2011 |
| Integration of the accelerator Aha1 in the Hsp90 co-chaperone cycle J Li, K Richter, J Reinstein, J Buchner Nature structural & molecular biology 20 (3), 326-331, 2013 | 158 | 2013 |
| Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11 J Li, T Yakushi, F Parlati, AL Mackinnon, C Perez, Y Ma, KP Carter, ... Nature chemical biology 13 (5), 486-493, 2017 | 155 | 2017 |
| Antibody targeting of E3 ubiquitin ligases for receptor degradation H Marei, WTK Tsai, YS Kee, K Ruiz, J He, C Cox, T Sun, S Penikalapati, ... Nature 610 (7930), 182-189, 2022 | 150 | 2022 |
| Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases L Lauinger, J Li, A Shostak, IA Cemel, N Ha, Y Zhang, PE Merkl, ... Nature chemical biology 13 (7), 709-714, 2017 | 119 | 2017 |
| Proteasome inhibitors: harnessing proteostasis to combat disease DJ Sherman, J Li Molecules 25 (3), 671, 2020 | 90 | 2020 |
| Discovery of an inhibitor of the proteasome subunit Rpn11 C Perez, J Li, F Parlati, M Rouffet, Y Ma, AL Mackinnon, TF Chou, ... Journal of medicinal chemistry 60 (4), 1343-1361, 2017 | 84 | 2017 |
| Increased proteasomal activity supports photoreceptor survival in inherited retinal degeneration ES Lobanova, S Finkelstein, J Li, AM Travis, Y Hao, M Klingeborn, ... Nature communications 9 (1), 1738, 2018 | 83 | 2018 |
| p97/VCP promotes degradation of CRBN substrate glutamine synthetase and neosubstrates TV Nguyen, J Li, CC Lu, JL Mamrosh, G Lu, BE Cathers, RJ Deshaies Proceedings of the National Academy of Sciences 114 (14), 3565-3571, 2017 | 82 | 2017 |
| Inhibition of COP9-signalosome (CSN) deneddylating activity and tumor growth of diffuse large B-cell lymphomas by doxycycline M Pulvino, L Chen, D Oleksyn, J Li, G Compitello, R Rossi, S Spence, ... Oncotarget 6 (17), 14796, 2015 | 49 | 2015 |
| Epidithiodiketopiperazines inhibit protein degradation by targeting proteasome deubiquitinase Rpn11 J Li, Y Zhang, BDSS Dos Santos, F Wang, Y Ma, C Perez, Y Yang, J Peng, ... Cell chemical biology 25 (11), 1350-1358. e9, 2018 | 44 | 2018 |
| Dual antibody inhibition of KLK5 and KLK7 for Netherton syndrome and atopic dermatitis J Chavarria-Smith, CPC Chiu, JK Jackman, J Yin, J Zhang, JA Hackney, ... Science Translational Medicine 14 (675), eabp9159, 2022 | 20 | 2022 |
| The unique proline-rich domain regulates the chaperone function of AIPL1 J Li, G Zoldak, T Kriehuber, J Soroka, FX Schmid, K Richter, J Buchner Biochemistry, 2013 | 20 | 2013 |
| Adaptive exchange sustains cullin–RING ubiquitin ligase networks and proper licensing of DNA replication Y Zhang, M Jost, RA Pak, D Lu, J Li, B Lomenick, SD Garbis, CM Li, ... Proceedings of the National Academy of Sciences 119 (36), e2205608119, 2022 | 18 | 2022 |
| Quantitative measurement of the requirement of diverse protein degradation pathways in MHC class I peptide presentation JL Mamrosh, DJ Sherman, JR Cohen, JA Johnston, MK Joubert, J Li, ... Science Advances 9 (25), eade7890, 2023 | 11 | 2023 |
| Inhibitors of RPN11 RJ Deshaies, J Li, S Cohen, C Perez, Y Ma US Patent 10,005,735, 2018 | 3 | 2018 |
| Discovery of an inhibitor of the Rpn11 proteasome subunit C Perez, J Li, F Parlati, M Rouffet, Y Ma, AL Mackinnon, TF Chou, ... ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 252, 2016 | | 2016 |
Yaru ZhangScientist, AmgenVerified email at caltech.edu