| Randomized trial of tocilizumab in systemic juvenile idiopathic arthritis F De Benedetti, HI Brunner, N Ruperto, A Kenwright, S Wright, I Calvo, ... New England Journal of Medicine 367 (25), 2385-2395, 2012 | 996 | 2012 |
| 2016 classification criteria for macrophage activation syndrome complicating systemic juvenile idiopathic arthritis: a European League Against Rheumatism/American College of … A Ravelli, F Minoia, S Davì, AC Horne, F Bovis, A Pistorio, M Aricò, ... Annals of the Rheumatic Diseases 75 (3), 481-489, 2016 | 953 | 2016 |
| Interleukin 6 is required for the development of collagen-induced arthritis T Alonzi, E Fattori, D Lazzaro, P Costa, L Probert, G Kollias, ... The Journal of experimental medicine 187 (4), 461-468, 1998 | 817 | 1998 |
| On the alert for cytokine storm: immunopathology in COVID‐19 LA Henderson, SW Canna, GS Schulert, S Volpi, PY Lee, KF Kernan, ... Arthritis & rheumatology 72 (7), 1059-1063, 2020 | 789 | 2020 |
| Interleukin 6 causes growth impairment in transgenic mice through a decrease in insulin-like growth factor-I. A model for stunted growth in children with chronic inflammation. F De Benedetti, T Alonzi, A Moretta, D Lazzaro, P Costa, V Poli, A Martini, ... The Journal of clinical investigation 99 (4), 643-650, 1997 | 625 | 1997 |
| Translating IL-6 biology into effective treatments EH Choy, F De Benedetti, T Takeuchi, M Hashizume, MR John, ... Nature Reviews Rheumatology 16 (6), 335-345, 2020 | 591 | 2020 |
| Canakinumab for the treatment of autoinflammatory recurrent fever syndromes F De Benedetti, M Gattorno, J Anton, E Ben-Chetrit, J Frenkel, ... New England Journal of Medicine 378 (20), 1908-1919, 2018 | 483 | 2018 |
| Emapalumab in children with primary hemophagocytic lymphohistiocytosis F Locatelli, MB Jordan, C Allen, S Cesaro, C Rizzari, A Rao, B Degar, ... New England Journal of Medicine 382 (19), 1811-1822, 2020 | 457 | 2020 |
| Correlation of serum interleukin‐6 levels with joint involvement and thrombocytosis in systemic juvenile rheumatoid arthritis F De Benedetti, M Massa, P Robbioni, A Ravelli, GR Burgio, A Martini Arthritis & Rheumatism: Official Journal of the American College of …, 1991 | 456 | 1991 |
| Macrophage activation syndrome in the era of biologic therapy AA Grom, AC Horne, F De Benedetti Nature Reviews Rheumatology 12 (5), 259-268, 2016 | 435 | 2016 |
| Classification criteria for autoinflammatory recurrent fevers M Gattorno, M Hofer, S Federici, F Vanoni, F Bovis, I Aksentijevich, ... Annals of the rheumatic diseases 78 (8), 1025-1032, 2019 | 431 | 2019 |
| Impaired skeletal development in interleukin‐6–transgenic mice: a model for the impact of chronic inflammation on the growing skeletal system F De Benedetti, N Rucci, A Del Fattore, B Peruzzi, R Paro, M Longo, ... Arthritis & Rheumatism: Official Journal of the American College of …, 2006 | 380 | 2006 |
| Treating juvenile idiopathic arthritis to target: recommendations of an international task force A Ravelli, A Consolaro, G Horneff, RM Laxer, DJ Lovell, NM Wulffraat, ... Annals of the rheumatic diseases 77 (6), 819-828, 2018 | 362 | 2018 |
| Mutation screening of the macrophage migration inhibitory factor gene: positive association of a functional polymorphism of macrophage migration inhibitory factor with juvenile … R Donn, Z Alourfi, F De Benedetti, C Meazza, E Zeggini, M Lunt, ... Arthritis & Rheumatism 46 (9), 2402-2409, 2002 | 340 | 2002 |
| Efficacy and safety of tocilizumab in patients with polyarticular-course juvenile idiopathic arthritis: results from a phase 3, randomised, double-blind withdrawal trial HI Brunner, N Ruperto, Z Zuber, C Keane, O Harari, A Kenwright, P Lu, ... Annals of the rheumatic diseases 74 (6), 1110-1117, 2015 | 324 | 2015 |
| NGF and its receptors in the regulation of inflammatory response G Minnone, F De Benedetti, L Bracci-Laudiero International journal of molecular sciences 18 (5), 1028, 2017 | 311 | 2017 |
| Inhibition of natural killer cell cytotoxicity by interleukin‐6: implications for the pathogenesis of macrophage activation syndrome L Cifaldi, G Prencipe, I Caiello, C Bracaglia, F Locatelli, F De Benedetti, ... Arthritis & rheumatology 67 (11), 3037-3046, 2015 | 301 | 2015 |
| Serum soluble interleukin 6 (IL-6) receptor and IL-6/soluble IL-6 receptor complex in systemic juvenile rheumatoid arthritis. F De Benedetti, M Massa, P Pignatti, S Albani, D Novick, A Martini The Journal of clinical investigation 93 (5), 2114-2119, 1994 | 287 | 1994 |
| Elevated circulating levels of interferon-γ and interferon-γ-induced chemokines characterise patients with macrophage activation syndrome complicating systemic juvenile … C Bracaglia, K de Graaf, DP Marafon, F Guilhot, W Ferlin, G Prencipe, ... Annals of the rheumatic diseases 76 (1), 166-172, 2017 | 281 | 2017 |
| Mutations in the perforin gene can be linked to macrophage activation syndrome in patients with systemic onset juvenile idiopathic arthritis SJ Vastert, R Van Wijk, LE D’Urbano, KMK De Vooght, W De Jager, ... Rheumatology 49 (3), 441-449, 2010 | 266 | 2010 |
