| Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, ... autophagy 17 (1), 1-382, 2021 | 13828* | 2021 |
| Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations JH Lee, WH Yu, A Kumar, S Lee, PS Mohan, CM Peterhoff, DM Wolfe, ... Cell 141 (7), 1146-1158, 2010 | 1311 | 2010 |
| Macroautophagy—a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease WH Yu, AM Cuervo, A Kumar, CM Peterhoff, SD Schmidt, JH Lee, ... The Journal of cell biology 171 (1), 87-98, 2005 | 1189 | 2005 |
| Copper (II)-induced self-oligomerization of α-synuclein SR Paik, HJ SHIN, JH LEE, CS CHANG, J KIM Biochemical Journal 340 (3), 821-828, 1999 | 452 | 1999 |
| Neurodegenerative lysosomal disorders: a continuum from development to late age RA Nixon, DS Yang, JH Lee Autophagy 4 (5), 590-599, 2008 | 428 | 2008 |
| Faulty autolysosome acidification in Alzheimer’s disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques JH Lee, DS Yang, CN Goulbourne, E Im, P Stavrides, A Pensalfini, ... Nature neuroscience 25 (6), 688-701, 2022 | 422 | 2022 |
| Autophagy failure in A lzheimer's disease and the role of defective lysosomal acidification DM Wolfe, J Lee, A Kumar, S Lee, SJ Orenstein, RA Nixon European journal of neuroscience 37 (12), 1949-1961, 2013 | 421 | 2013 |
| Presenilin 1 maintains lysosomal Ca2+ homeostasis via TRPML1 by regulating vATPase-mediated lysosome acidification JH Lee, MK McBrayer, DM Wolfe, LJ Haslett, A Kumar, Y Sato, PPY Lie, ... Cell reports 12 (9), 1430-1444, 2015 | 356 | 2015 |
| Metal-catalyzed oxidation of α-synuclein in the presence of copper (II) and hydrogen peroxide SR Paik, HJ Shin, JH Lee Archives of biochemistry and biophysics 378 (2), 269-277, 2000 | 232 | 2000 |
| Aluminum-induced structural alterations of the precursor of the non-Aβ component of Alzheimer's disease amyloid SR Paik, JH Lee, DH Kim, CS Chang, J Kim Archives of biochemistry and biophysics 344 (2), 325-334, 1997 | 194 | 1997 |
| Neurofilament subunits are integral components of synapses and modulate neurotransmission and behavior in vivo A Yuan, H Sershen, BS Basavarajappa, A Kumar, A Hashim, M Berg, ... Molecular psychiatry 20 (8), 986-994, 2015 | 140 | 2015 |
| The neuronal adaptor protein X11α reduces Aβ levels in the brains of Alzheimer's APPswe Tg2576 transgenic mice JH Lee, KF Lau, MS Perkinton, CL Standen, SJA Shemilt, L Mercken, ... Journal of Biological Chemistry 278 (47), 47025-47029, 2003 | 114 | 2003 |
| Endosomal dysfunction induced by directly overactivating Rab5 recapitulates prodromal and neurodegenerative features of Alzheimer’s disease A Pensalfini, S Kim, S Subbanna, C Bleiwas, CN Goulbourne, ... Cell reports 33 (8), 2020 | 91 | 2020 |
| The neuronal adaptor protein X11β reduces amyloid β-protein levels and amyloid plaque formation in the brains of transgenic mice JH Lee, KF Lau, MS Perkinton, CL Standen, B Rogelj, A Falinska, ... Journal of Biological Chemistry 279 (47), 49099-49104, 2004 | 86 | 2004 |
| Self‐oligomerization of NACP, the precursor protein of the non‐amyloid β/A4 protein (Aβ) component of Alzheimer's disease amyloid, observed in the presence of a C‐terminal Aβ … SR Paik, JH Lee, DH Kim, CS Chang, YS Kim FEBS letters 421 (1), 73-76, 1998 | 85 | 1998 |
| Transgenic expression of a ratiometric autophagy probe specifically in neurons enables the interrogation of brain autophagy in vivo JH Lee, MV Rao, DS Yang, P Stavrides, E Im, A Pensalfini, C Huo, ... Autophagy 15 (3), 543-557, 2019 | 66 | 2019 |
| Declining phosphatases underlie aging-related hyperphosphorylation of neurofilaments DS Yang, JH Lee, KY Vinod, P Stavrides, ND Amin, HC Pant, RA Nixon Neurobiology of aging 32 (11), 2016-2029, 2011 | 44 | 2011 |
| Axonal transport of late endosomes and amphisomes is selectively modulated by local Ca2+ efflux and disrupted by PSEN1 loss of function PPY Lie, L Yoo, CN Goulbourne, MJ Berg, P Stavrides, C Huo, JH Lee, ... Science advances 8 (17), eabj5716, 2022 | 42 | 2022 |
| Monitoring autophagy in Alzheimer's disease and related neurodegenerative diseases DS Yang, JH Lee, RA Nixon Methods in enzymology 453, 111-144, 2009 | 35 | 2009 |
| Neurofilament tail phosphorylation: identity of the RT‐97 phosphoepitope and regulation in neurons by cross‐talk among proline‐directed kinases Veeranna, JH Lee, TK Pareek, H Jaffee, B Boland, KY Vinod, N Amin, ... Journal of neurochemistry 107 (1), 35-49, 2008 | 34 | 2008 |
Ralph A NixonProfessor of Psychiatry and Cell Biology New York UniversityVerified email at nki.rfmh.org
