GPCR dynamics: structures in motion NR Latorraca, AJ Venkatakrishnan, RO Dror Chemical reviews 117 (1), 139-155, 2017 | 823 | 2017 |
Structure of the µ-opioid receptor–Gi protein complex A Koehl, H Hu, S Maeda, Y Zhang, Q Qu, JM Paggi, NR Latorraca, ... Nature 558 (7711), 547-552, 2018 | 681 | 2018 |
Identification of phosphorylation codes for arrestin recruitment by G protein-coupled receptors XE Zhou, Y He, PW de Waal, X Gao, Y Kang, N Van Eps, Y Yin, K Pal, ... Cell 170 (3), 457-469. e13, 2017 | 442 | 2017 |
Structure of a signaling cannabinoid receptor 1-G protein complex KK Kumar, M Shalev-Benami, MJ Robertson, H Hu, SD Banister, ... Cell 176 (3), 448-458. e12, 2019 | 412 | 2019 |
Structure of the M2 muscarinic receptor–β-arrestin complex in a lipid nanodisc DP Staus, H Hu, MJ Robertson, ALW Kleinhenz, LM Wingler, WD Capel, ... Nature 579 (7798), 297-302, 2020 | 306 | 2020 |
Angiotensin analogs with divergent bias stabilize distinct receptor conformations LM Wingler, M Elgeti, D Hilger, NR Latorraca, MT Lerch, DP Staus, ... Cell 176 (3), 468-478. e11, 2019 | 256 | 2019 |
Conformational transitions of a neurotensin receptor 1–Gi1 complex HE Kato, Y Zhang, H Hu, CM Suomivuori, FMN Kadji, J Aoki, ... Nature 572 (7767), 80-85, 2019 | 240 | 2019 |
Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure X Liu, S Ahn, AW Kahsai, KC Meng, NR Latorraca, B Pani, ... Nature 548 (7668), 480-484, 2017 | 214 | 2017 |
Molecular mechanism of GPCR-mediated arrestin activation NR Latorraca, JK Wang, B Bauer, RJL Townshend, SA Hollingsworth, ... Nature 557 (7705), 452-456, 2018 | 212 | 2018 |
Molecular mechanism of biased signaling in a prototypical G-protein-coupled receptor CM Suomivuori, NR Latorraca, LM Wingler, S Eismann, MC King, ... Biophysical Journal 118 (3), 162a, 2020 | 211 | 2020 |
Catalytic activation of β-arrestin by GPCRs K Eichel, D Jullié, B Barsi-Rhyne, NR Latorraca, M Masureel, JB Sibarita, ... Nature 557 (7705), 381-386, 2018 | 207 | 2018 |
Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR LM Wingler, MA Skiba, C McMahon, DP Staus, ALW Kleinhenz, ... Science 367 (6480), 888-892, 2020 | 203 | 2020 |
Smoothened stimulation by membrane sterols drives Hedgehog pathway activity I Deshpande, J Liang, D Hedeen, KJ Roberts, Y Zhang, B Ha, ... Nature 571 (7764), 284-288, 2019 | 200 | 2019 |
Diverse GPCRs exhibit conserved water networks for stabilization and activation AJ Venkatakrishnan, AK Ma, R Fonseca, NR Latorraca, B Kelly, RM Betz, ... Proceedings of the National Academy of Sciences 116 (8), 3288-3293, 2019 | 146 | 2019 |
Structural and functional characterization of G protein–coupled receptors with deep mutational scanning EM Jones, NB Lubock, AJ Venkatakrishnan, J Wang, AM Tseng, JM Paggi, ... Elife 9, e54895, 2020 | 133 | 2020 |
How GPCR phosphorylation patterns orchestrate arrestin-mediated signaling NR Latorraca, M Masureel, SA Hollingsworth, FM Heydenreich, ... Cell 183 (7), 1813-1825. e18, 2020 | 132 | 2020 |
Revealing atomic-level mechanisms of protein allostery with molecular dynamics simulations S Hertig, NR Latorraca, RO Dror PLoS computational biology 12 (6), e1004746, 2016 | 121 | 2016 |
Structure and mechanism of the cation–chloride cotransporter NKCC1 TA Chew, BJ Orlando, J Zhang, NR Latorraca, A Wang, SA Hollingsworth, ... Nature 572 (7770), 488-492, 2019 | 120 | 2019 |
Mechanism of substrate translocation in an alternating access transporter NR Latorraca, NM Fastman, AJ Venkatakrishnan, WB Frommer, RO Dror, ... Cell 169 (1), 96-107. e12, 2017 | 103 | 2017 |
Gi-and Gs-coupled GPCRs show different modes of G-protein binding N Van Eps, C Altenbach, LN Caro, NR Latorraca, SA Hollingsworth, ... Proceedings of the National Academy of Sciences 115 (10), 2383-2388, 2018 | 95 | 2018 |