| Identification of host proteins required for HIV infection through a functional genomic screen AL Brass, DM Dykxhoorn, Y Benita, N Yan, A Engelman, RJ Xavier, ... science 319 (5865), 921-926, 2008 | 1815 | 2008 |
| Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses D Gao, J Wu, YT Wu, F Du, C Aroh, N Yan, L Sun, ZJ Chen Science 341 (6148), 903-906, 2013 | 1132 | 2013 |
| miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to “seedless” 3′ UTR microRNA recognition elements A Lal, F Navarro, CA Maher, LE Maliszewski, N Yan, E O'Day, ... Molecular cell 35 (5), 610-625, 2009 | 701 | 2009 |
| Intrinsic antiviral immunity N Yan, ZJ Chen Nature immunology 13 (3), 214-222, 2012 | 664 | 2012 |
| The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1 N Yan, AD Regalado-Magdos, B Stiggelbout, M Lee-Kirsch, J Lieberman Nature immunology 11 (11), 1005-1013, 2010 | 613 | 2010 |
| STING activation by translocation from the ER is associated with infection and autoinflammatory disease N Dobbs, N Burnaevskiy, D Chen, VK Gonugunta, NM Alto, N Yan Cell host & microbe 18 (2), 157-168, 2015 | 589 | 2015 |
| Trafficking-mediated STING degradation requires sorting to acidified endolysosomes and can be targeted to enhance anti-tumor response VK Gonugunta, T Sakai, V Pokatayev, K Yang, J Wu, N Dobbs, N Yan Cell reports 21 (11), 3234-3242, 2017 | 269 | 2017 |
| Interferon-independent activities of mammalian STING mediate antiviral response and tumor immune evasion J Wu, N Dobbs, K Yang, N Yan Immunity 53 (1), 115-126. e5, 2020 | 267 | 2020 |
| STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death J Wu, YJ Chen, N Dobbs, T Sakai, J Liou, JJ Miner, N Yan Journal of Experimental Medicine 216 (4), 867-883, 2019 | 251 | 2019 |
| RNase H2 catalytic core Aicardi-Goutières syndrome–related mutant invokes cGAS–STING innate immune-sensing pathway in mice V Pokatayev, N Hasin, H Chon, SM Cerritelli, K Sakhuja, JM Ward, ... Journal of Experimental Medicine 213 (3), 329-336, 2016 | 235 | 2016 |
| STING-associated vasculopathy develops independently of IRF3 in mice JD Warner, RA Irizarry-Caro, BG Bennion, TL Ai, AM Smith, CA Miner, ... Journal of Experimental Medicine 214 (11), 3279-3292, 2017 | 183 | 2017 |
| DNA polymerase-α regulates the activation of type I interferons through cytosolic RNA: DNA synthesis P Starokadomskyy, T Gemelli, JJ Rios, C Xing, RC Wang, H Li, ... Nature immunology 17 (5), 495-504, 2016 | 161 | 2016 |
| Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes M Hasan, J Koch, D Rakheja, AK Pattnaik, J Brugarolas, I Dozmorov, ... Nature immunology 14 (1), 61-71, 2013 | 161 | 2013 |
| Tonic prime-boost of STING signalling mediates Niemann–Pick disease type C TT Chu, X Tu, K Yang, J Wu, JJ Repa, N Yan Nature 596 (7873), 570-575, 2021 | 159 | 2021 |
| N-glycanase NGLY1 regulates mitochondrial homeostasis and inflammation through NRF1 K Yang, R Huang, H Fujihira, T Suzuki, N Yan Journal of Experimental Medicine 215 (10), 2600-2616, 2018 | 127 | 2018 |
| Cytosolic nuclease TREX1 regulates oligosaccharyltransferase activity independent of nuclease activity to suppress immune activation M Hasan, CS Fermaintt, N Gao, T Sakai, T Miyazaki, S Jiang, QZ Li, ... Immunity 43 (3), 463-474, 2015 | 125 | 2015 |
| The SET complex acts as a barrier to autointegration of HIV-1 N Yan, P Cherepanov, JE Daigle, A Engelman, J Lieberman PLoS pathogens 5 (3), e1000327, 2009 | 108 | 2009 |
| Immune diseases associated with TREX1 and STING dysfunction N Yan Journal of Interferon & Cytokine Research 37 (5), 198-206, 2017 | 104 | 2017 |
| Chronic innate immune activation of TBK1 suppresses mTORC1 activity and dysregulates cellular metabolism M Hasan, VK Gonugunta, N Dobbs, A Ali, G Palchik, MA Calvaruso, ... Proceedings of the National Academy of Sciences 114 (4), 746-751, 2017 | 103 | 2017 |
| Homeostatic regulation of STING protein at the resting state by stabilizer TOLLIP V Pokatayev, K Yang, X Tu, N Dobbs, J Wu, RG Kalb, N Yan Nature immunology 21 (2), 158-167, 2020 | 99 | 2020 |