| Intracellular delivery of peptidyl ligands by reversible cyclization: discovery of a PDZ domain inhibitor that rescues CFTR activity Z Qian, X Xu, JF Amacher, DR Madden, E Cormet‐Boyaka, D Pei Angewandte Chemie 127 (20), 5972-5976, 2015 | 91 | 2015 |
| The Src module: an ancient scaffold in the evolution of cytoplasmic tyrosine kinases NH Shah, JF Amacher, LM Nocka, J Kuriyan Critical reviews in biochemistry and molecular biology 53 (5), 535-563, 2018 | 84 | 2018 |
| A phosphosite within the SH2 domain of Lck regulates its activation by CD45 AH Courtney, JF Amacher, TA Kadlecek, MN Mollenauer, BB Au-Yeung, ... Molecular cell 67 (3), 498-511. e6, 2017 | 71 | 2017 |
| A Compact Structure of Cytochrome c Trapped in a Lysine-Ligated State: Loop Refolding and Functional Implications of a Conformational Switch JF Amacher, F Zhong, GP Lisi, MQ Zhu, SL Alden, KR Hoke, DR Madden, ... Journal of the American Chemical Society 137 (26), 8435-8449, 2015 | 63 | 2015 |
| Specificity in PDZ-peptide interaction networks: Computational analysis and review JF Amacher, L Brooks 3rd, TH Hampton, DR Madden Journal of Structural Biology: X 4, 100022, 2020 | 62 | 2020 |
| Stereochemical preferences modulate affinity and selectivity among five PDZ domains that bind CFTR: comparative structural and sequence analyses JF Amacher, PR Cushing, L Brooks, P Boisguerin, DR Madden Structure 22 (1), 82-93, 2014 | 49 | 2014 |
| Stereochemical determinants of C-terminal specificity in PDZ peptide-binding domains: a novel contribution of the carboxylate-binding loop JF Amacher, PR Cushing, CD Bahl, T Beck, DR Madden Journal of Biological Chemistry 288 (7), 5114-5126, 2013 | 42 | 2013 |
| Chemically modified peptide scaffolds target the CFTR-associated ligand PDZ domain JF Amacher, R Zhao, MR Spaller, DR Madden PloS one 9 (8), e103650, 2014 | 26 | 2014 |
| Sequence variation in the β7–β8 loop of bacterial class A sortase enzymes alters substrate selectivity IM Piper, SA Struyvenberg, JD Valgardson, DA Johnson, M Gao, ... Journal of Biological Chemistry 297 (2), 2021 | 20 | 2021 |
| Structures of Streptococcus pyogenes class A sortase in complex with substrate and product mimics provide key details of target recognition DA Johnson, IM Piper, BA Vogel, SN Jackson, JE Svendsen, HM Kodama, ... Journal of Biological Chemistry 298 (10), 2022 | 19 | 2022 |
| Crystallization and preliminary diffraction analysis of the CAL PDZ domain in complex with a selective peptide inhibitor JF Amacher, PR Cushing, JA Weiner, DR Madden Acta Crystallographica Section F: Structural Biology and Crystallization …, 2011 | 17 | 2011 |
| Structural and biochemical analyses of selectivity determinants in chimeric Streptococcus Class A sortase enzymes M Gao, DA Johnson, IM Piper, HM Kodama, JE Svendsen, E Tahti, ... Protein Science 31 (3), 701-715, 2022 | 15 | 2022 |
| MotifAnalyzer‐PDZ: A computational program to investigate the evolution of PDZ‐binding target specificity J Valgardson, R Cosbey, P Houser, M Rupp, R Van Bronkhorst, M Lee, ... Protein Science 28 (12), 2127-2143, 2019 | 15 | 2019 |
| Saturation mutagenesis of a predicted ancestral Syk‐family kinase HT Hobbs, NH Shah, SR Shoemaker, JF Amacher, S Marqusee, J Kuriyan Protein Science 31 (10), e4411, 2022 | 14 | 2022 |
| Comparative analysis and ancestral sequence reconstruction of bacterial sortase family proteins generates functional ancestral mutants with different sequence specificities JD Valgardson, SA Struyvenberg, ZR Sailer, IM Piper, JE Svendsen, ... Bacteria 1 (2), 121-135, 2022 | 9 | 2022 |
| Phosphorylation control of the ubiquitin ligase Cbl is conserved in choanoflagellates JF Amacher, HT Hobbs, AC Cantor, L Shah, MJ Rivero, SA Mulchand, ... Protein Science 27 (5), 923-932, 2018 | 9 | 2018 |
| Sortases: structure, mechanism, and implications for protein engineering JF Amacher, JM Antos Trends in Biochemical Sciences, 2024 | 6 | 2024 |
| Structural characterization and computational analysis of PDZ domains in Monosiga brevicollis M Gao, IGP Mackley, S Mesbahi‐Vasey, HA Bamonte, SA Struyvenberg, ... Protein Science 29 (11), 2226-2244, 2020 | 6 | 2020 |
| A unique binding mode of P1′ Leu-containing target sequences for Streptococcus pyogenes sortase A results in alternative cleavage BA Vogel, JM Blount, HM Kodama, NJ Goodwin-Rice, DJ Andaluz, ... RSC Chemical Biology 5 (1), 30-40, 2024 | 4 | 2024 |
| Additive energetic contributions of multiple peptide positions determine the relative promiscuity of viral and human sequences for PDZ domain targets EF Tahti, JM Blount, SN Jackson, M Gao, NP Gill, SN Smith, NJ Pederson, ... Protein Science 32 (4), e4611, 2023 | 4 | 2023 |
