| Therapeutic interleukin-6 trans-signaling inhibition by olamkicept (sgp130Fc) in patients with active inflammatory bowel disease S Schreiber, K Aden, JP Bernardes, C Conrad, F Tran, H Höper, V Volk, ... Gastroenterology 160 (7), 2354-2366. e11, 2021 | 198 | 2021 |
| The interleukin-6 receptor Asp358Ala single nucleotide polymorphism rs2228145 confers increased proteolytic conversion rates by ADAM proteases C Garbers, N Monhasery, S Aparicio-Siegmund, J Lokau, P Baran, ... Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1842 (9 …, 2014 | 159 | 2014 |
| Control of ADAM17 activity by regulation of its cellular localisation I Lorenzen, J Lokau, Y Korpys, M Oldefest, CM Flynn, U Künzel, ... Scientific reports 6 (1), 35067, 2016 | 138 | 2016 |
| Proteolytic origin of the soluble human IL-6R in vivo and a decisive role of N-glycosylation S Riethmueller, P Somasundaram, JC Ehlers, CW Hung, CM Flynn, ... PLoS biology 15 (1), e2000080, 2017 | 135 | 2017 |
| Proteolytic cleavage governs interleukin-11 trans-signaling J Lokau, R Nitz, M Agthe, N Monhasery, S Aparicio-Siegmund, ... Cell reports 14 (7), 1761-1773, 2016 | 130 | 2016 |
| The metalloprotease ADAM17 in inflammation and cancer S Düsterhöft, J Lokau, C Garbers Pathology-Research and Practice 215 (6), 152410, 2019 | 116 | 2019 |
| Jak-stat signaling induced by interleukin-6 family cytokines in hepatocellular carcinoma J Lokau, V Schoeder, J Haybaeck, C Garbers Cancers 11 (11), 1704, 2019 | 106 | 2019 |
| Cleavage site localization differentially controls interleukin-6 receptor proteolysis by ADAM10 and ADAM17 S Riethmueller, JC Ehlers, J Lokau, S Düsterhöft, K Knittler, ... Scientific reports 6 (1), 25550, 2016 | 102 | 2016 |
| The membrane-proximal domain of A Disintegrin and Metalloprotease 17 (ADAM17) is responsible for recognition of the interleukin-6 receptor and interleukin-1 receptor II I Lorenzen, J Lokau, S Düsterhöft, A Trad, C Garbers, J Scheller, ... FEBS letters 586 (8), 1093-1100, 2012 | 98 | 2012 |
| A disintegrin and metalloprotease 17 dynamic interaction sequence, the sweet tooth for the human interleukin 6 receptor S Düsterhöft, K Höbel, M Oldefest, J Lokau, GH Waetzig, A Chalaris, ... Journal of Biological Chemistry 289 (23), 16336-16348, 2014 | 91 | 2014 |
| ADAM17 is required for EGF-R–induced intestinal tumors via IL-6 trans-signaling S Schmidt, N Schumacher, J Schwarz, S Tangermann, L Kenner, ... Journal of Experimental Medicine 215 (4), 1205-1225, 2018 | 72 | 2018 |
| Generation of soluble interleukin‐11 and interleukin‐6 receptors: a crucial function for proteases during inflammation J Lokau, M Agthe, C Garbers Mediators of inflammation 2016 (1), 1785021, 2016 | 63 | 2016 |
| Activation of Toll-like Receptor 2 (TLR2) induces Interleukin-6 trans-signaling CM Flynn, Y Garbers, J Lokau, D Wesch, DM Schulte, M Laudes, W Lieb, ... Scientific reports 9 (1), 7306, 2019 | 62 | 2019 |
| Meprin metalloproteases generate biologically active soluble interleukin-6 receptor to induce trans-signaling P Arnold, I Boll, M Rothaug, N Schumacher, F Schmidt, R Wichert, ... Scientific reports 7 (1), 44053, 2017 | 62 | 2017 |
| Proteolytic control of Interleukin-11 and Interleukin-6 biology J Lokau, M Agthe, CM Flynn, C Garbers Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1864 (11), 2105-2117, 2017 | 53 | 2017 |
| Biological functions and therapeutic opportunities of soluble cytokine receptors J Lokau, C Garbers Cytokine & growth factor reviews 55, 94-108, 2020 | 52 | 2020 |
| Function and proteolytic generation of the soluble interleukin-6 receptor in health and disease T Schumertl, J Lokau, S Rose-John, C Garbers Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1869 (1), 119143, 2022 | 51 | 2022 |
| Kinetics of cytokine receptor trafficking determine signaling and functional selectivity J Martinez-Fabregas, S Wilmes, L Wang, M Hafer, E Pohler, J Lokau, ... Elife 8, e49314, 2019 | 42 | 2019 |
| The cytokine interleukin-11 crucially links bone formation, remodeling and resorption B Kespohl, T Schumertl, J Bertrand, J Lokau, C Garbers Cytokine & growth factor reviews 60, 18-27, 2021 | 39 | 2021 |
| Activating mutations of the gp130/JAK/STAT pathway in human diseases J Lokau, C Garbers Advances in Protein Chemistry and Structural Biology 116, 283-309, 2019 | 36 | 2019 |
