| Sequential modification of NEMO/IKKγ by SUMO-1 and ubiquitin mediates NF-κB activation by genotoxic stress TT Huang, SM Wuerzberger-Davis, ZH Wu, S Miyamoto Cell 115 (5), 565-576, 2003 | 729 | 2003 |
| The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway SMB Nijman, TT Huang, AMG Dirac, TR Brummelkamp, RM Kerkhoven, ... Molecular cell 17 (3), 331-339, 2005 | 703 | 2005 |
| Regulation of monoubiquitinated PCNA by DUB autocleavage TT Huang, SMB Nijman, KD Mirchandani, PJ Galardy, MA Cohn, W Haas, ... Nature cell biology 8 (4), 341-347, 2006 | 675 | 2006 |
| A nuclear export signal in the N-terminal regulatory domain of IκBα controls cytoplasmic localization of inactive NF-κB/IκBα complexes TT Huang, N Kudo, M Yoshida, S Miyamoto Proceedings of the National Academy of Sciences 97 (3), 1014-1019, 2000 | 559 | 2000 |
| A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway MA Cohn, P Kowal, K Yang, W Haas, TT Huang, SP Gygi, AD D'Andrea Molecular cell 28 (5), 786-797, 2007 | 399 | 2007 |
| Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti–COVID-19 drug design W Rut, Z Lv, M Zmudzinski, S Patchett, D Nayak, SJ Snipas, F El Oualid, ... Science advances 6 (42), eabd4596, 2020 | 371 | 2020 |
| Regulation of DNA repair by ubiquitylation TT Huang, AD D'Andrea Nature reviews Molecular cell biology 7 (5), 323-334, 2006 | 360 | 2006 |
| FANCI is a second monoubiquitinated member of the Fanconi anemia pathway AE Sims, E Spiteri, RJ Sims III, AG Arita, FP Lach, T Landers, M Wurm, ... Nature structural & molecular biology 14 (6), 564-567, 2007 | 325 | 2007 |
| NF-κB activation by camptothecin: a linkage between nuclear DNA damage and cytoplasmic signaling events TT Huang, SM Wuerzberger-Davis, BJ Seufzer, SD Shumway, T Kurama, ... Journal of Biological Chemistry 275 (13), 9501-9509, 2000 | 226 | 2000 |
| ATR-mediated phosphorylation of FANCI regulates dormant origin firing in response to replication stress YH Chen, MJK Jones, Y Yin, SB Crist, L Colnaghi, RJ Sims, E Rothenberg, ... Molecular cell 58 (2), 323-338, 2015 | 181 | 2015 |
| Transcription shapes DNA replication initiation and termination in human cells YH Chen, S Keegan, M Kahli, P Tonzi, D Fenyö, TT Huang, DJ Smith Nature structural & molecular biology 26 (1), 67-77, 2019 | 163 | 2019 |
| Deubiquitinases as a signaling target of oxidative stress XM Cotto-Rios, M Békés, J Chapman, B Ueberheide, TT Huang Cell reports 2 (6), 1475-1484, 2012 | 163 | 2012 |
| Postrepression activation of NF-κB requires the amino-terminal nuclear export signal specific to IκBα TT Huang, S Miyamoto Molecular and cellular biology 21 (14), 4737-4747, 2001 | 158 | 2001 |
| Recognition of Lys48-linked di-ubiquitin and deubiquitinating activities of the SARS coronavirus papain-like protease M Békés, R Ekkebus, H Ovaa, TT Huang, CD Lima Molecular cell 62 (4), 572-585, 2016 | 153 | 2016 |
| The zinc finger domain of NEMO is selectively required for NF-κB activation by UV radiation and topoisomerase inhibitors TT Huang, SL Feinberg, S Suryanarayanan, S Miyamoto Molecular and cellular biology 22 (16), 5813-5825, 2002 | 139 | 2002 |
| Activity profiling and structures of inhibitor-bound SARS-CoV-2-PLpro protease provides a framework for anti-COVID-19 drug design W Rut, Z Lv, M Zmudzinski, S Patchett, D Nayak, SJ Snipas, F El Oualid, ... biorxiv, 2020.04. 29.068890, 2020 | 116 | 2020 |
| Role of deubiquitinating enzymes in DNA repair Y Kee, TT Huang Molecular and cellular biology, 2016 | 88 | 2016 |
| Targeting SARS-CoV-2 proteases for COVID-19 antiviral development Z Lv, KE Cano, L Jia, M Drag, TT Huang, SK Olsen Frontiers in Chemistry 9, 819165, 2022 | 82 | 2022 |
| Dysregulation of DNA polymerase κ recruitment to replication forks results in genomic instability MJK Jones, L Colnaghi, TT Huang The EMBO journal 31 (4), 908-918, 2012 | 78 | 2012 |
| Single-molecule imaging reveals replication fork coupled formation of G-quadruplex structures hinders local replication stress signaling WTC Lee, Y Yin, MJ Morten, P Tonzi, PP Gwo, DC Odermatt, M Modesti, ... Nature communications 12 (1), 2525, 2021 | 76 | 2021 |
