| A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models X Yu, D Li, J Kottur, Y Shen, HS Kim, KS Park, YH Tsai, W Gong, J Wang, ... Science translational medicine 13 (613), eabj1578, 2021 | 103 | 2021 |
| Structure and regulation of ZCCHC4 in m6A-methylation of 28S rRNA W Ren, J Lu, M Huang, L Gao, D Li, GG Wang, J Song Nature communications 10 (1), 5042, 2019 | 100 | 2019 |
| Harnessing the E3 ligase KEAP1 for targeted protein degradation J Wei, F Meng, KS Park, H Yim, J Velez, P Kumar, L Wang, L Xie, H Chen, ... Journal of the American Chemical Society 143 (37), 15073-15083, 2021 | 98 | 2021 |
| ZFX mediates non-canonical oncogenic functions of the androgen receptor splice variant 7 in castrate-resistant prostate cancer L Cai, YH Tsai, P Wang, J Wang, D Li, H Fan, Y Zhao, R Bareja, R Lu, ... Molecular cell 72 (2), 341-354. e6, 2018 | 89 | 2018 |
| BAHCC1 binds H3K27me3 via a conserved BAH module to mediate gene silencing and oncogenesis H Fan, J Lu, Y Guo, D Li, ZM Zhang, YH Tsai, WC Pi, JH Ahn, W Gong, ... Nature genetics 52 (12), 1384-1396, 2020 | 82 | 2020 |
| Discovery and characterization of a cellular potent positive allosteric modulator of the polycomb repressive complex 1 chromodomain, CBX7 KN Lamb, D Bsteh, SN Dishman, HF Moussa, H Fan, JI Stuckey, JL Norris, ... Cell chemical biology 26 (10), 1365-1379. e22, 2019 | 49 | 2019 |
| A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells C Xu, F Meng, KS Park, AJ Storey, W Gong, YH Tsai, E Gibson, SD Byrum, ... Cell chemical biology 29 (3), 386-397. e9, 2022 | 46 | 2022 |
| Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic D Li, X Yu, J Kottur, W Gong, Z Zhang, AJ Storey, YH Tsai, H Uryu, Y Shen, ... Oncogene 41 (24), 3328-3340, 2022 | 39 | 2022 |
| E2A-PBX1 functions as a coactivator for RUNX1 in acute lymphoblastic leukemia WC Pi, J Wang, M Shimada, JW Lin, H Geng, YL Lee, R Lu, D Li, ... Blood, The Journal of the American Society of Hematology 136 (1), 11-23, 2020 | 38 | 2020 |
| HISTONE DEACETYLASE6-defective mutants show increased expression and acetylation of ENHANCER OF TRIPTYCHON AND CAPRICE1 and GLABRA2 with small but significant effects on root … DX Li, WQ Chen, ZH Xu, SN Bai Plant physiology 168 (4), 1448-1458, 2015 | 34 | 2015 |
| Histone deacetylase HDA19 affects root cortical cell fate by interacting with SCARECROW WQ Chen, C Drapek, DX Li, ZH Xu, PN Benfey, SN Bai Plant Physiology 180 (1), 276-288, 2019 | 19 | 2019 |
| Reprogramming CBX8-PRC1 function with a positive allosteric modulator JL Suh, D Bsteh, B Hart, Y Si, TM Weaver, C Pribitzer, R Lau, S Soni, ... Cell chemical biology 29 (4), 555-571. e11, 2022 | 18 | 2022 |
| Novel RNA-affinity proteogenomics dissects tumor heterogeneity for revealing personalized markers in precision prognosis of cancer L Wang, JA Wrobel, L Xie, DX Li, G Zurlo, H Shen, P Yang, Z Wang, ... Cell chemical biology 25 (5), 619-633. e5, 2018 | 18 | 2018 |
| One additional histone deacetylase and 2 histone acetyltransferases are involved in cellular patterning of Arabidopsis root epidermis WQ Chen, DX Li, F Zhao, ZH Xu, SN Bai Plant signaling & behavior 11 (2), e1131373, 2016 | 16 | 2016 |
| DOT1L activity in leukemia cells requires interaction with ubiquitylated H2B that promotes productive nucleosome binding CJ Spangler, SP Yadav, D Li, CN Geil, CB Smith, GG Wang, TH Lee, ... Cell reports 38 (7), 2022 | 14 | 2022 |
| Discovery of potent and selective WDR5 proteolysis targeting chimeras as potential therapeutics for pancreatic cancer X Yu, D Li, J Kottur, HS Kim, LE Herring, Y Yu, L Xie, X Hu, X Chen, L Cai, ... Journal of Medicinal Chemistry 66 (23), 16168-16186, 2023 | 7 | 2023 |
| A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models. Sci Transl Med, 13 (613), eabj1578 X Yu, D Li, J Kottur, Y Shen, HS Kim, KS Park, YH Tsai, W Gong, J Wang, ... | 5 | 2021 |
| Wd40 repeat domain protein 5 (wdr5) degradation/disruption compounds and methods of use J Jin, G Wang, J Liu, YU Xufen, D Li | 2 | 2019 |
