| JAK/STAT cytokine signaling at the crossroad of NK cell development and maturation D Gotthardt, J Trifinopoulos, V Sexl, EM Putz Frontiers in immunology 10, 2590, 2019 | 174 | 2019 |
| Loss of HIF-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesis E Krzywinska, C Kantari-Mimoun, Y Kerdiles, M Sobecki, T Isagawa, ... Nature communications 8 (1), 1597, 2017 | 159 | 2017 |
| STAT5 is a key regulator in NK cells and acts as a molecular switch from tumor surveillance to tumor promotion D Gotthardt, EM Putz, E Grundschober, M Prchal-Murphy, E Straka, ... Cancer Discovery 6 (4), 414-429, 2016 | 155 | 2016 |
| CDK8-mediated STAT1-S727 phosphorylation restrains NK cell cytotoxicity and tumor surveillance EM Putz, D Gotthardt, G Hoermann, A Csiszar, S Wirth, A Berger, E Straka, ... Cell reports 4 (3), 437-444, 2013 | 138 | 2013 |
| STATs in NK-cells: the good, the bad, and the ugly D Gotthardt, V Sexl Frontiers in immunology 7, 694, 2017 | 130 | 2017 |
| Loss of STAT3 in murine NK cells enhances NK cell–dependent tumor surveillance D Gotthardt, EM Putz, E Straka, P Kudweis, M Biaggio, V Poli, B Strobl, ... Blood, The Journal of the American Society of Hematology 124 (15), 2370-2379, 2014 | 129 | 2014 |
| Decreased NK-cell tumour immunosurveillance consequent to JAK inhibition enhances metastasis in breast cancer models A Bottos, D Gotthardt, JW Gill, A Gattelli, A Frei, A Tzankov, V Sexl, ... Nature communications 7 (1), 12258, 2016 | 96 | 2016 |
| Cutting edge: IL-2–induced expression of the amino acid transporters SLC1A5 and CD98 is a prerequisite for NKG2D-mediated activation of human NK cells H Jensen, M Potempa, D Gotthardt, LL Lanier The Journal of Immunology 199 (6), 1967-1972, 2017 | 79 | 2017 |
| Conditional IFNAR1 ablation reveals distinct requirements of Type I IFN signaling for NK cell maturation and tumor surveillance T Mizutani, N Neugebauer, EM Putz, N Moritz, O Simma, ... Oncoimmunology 1 (7), 1027-1037, 2012 | 64 | 2012 |
| NK Cell–Specific CDK8 deletion enhances antitumor responses A Witalisz-Siepracka, D Gotthardt, M Prchal-Murphy, Z Didara, I Menzl, ... Cancer immunology research 6 (4), 458-466, 2018 | 46 | 2018 |
| NK cells in hypoxic skin mediate a trade-off between wound healing and antibacterial defence M Sobecki, E Krzywinska, S Nagarajan, A Audigé, K Huỳnh, J Zacharjasz, ... Nature communications 12 (1), 4700, 2021 | 45 | 2021 |
| The transcription factor HIF-1α mediates plasticity of NKp46+ innate lymphoid cells in the gut E Krzywinska, M Sobecki, S Nagarajan, J Zacharjasz, MM Tambuwala, ... Journal of Experimental Medicine 219 (2), e20210909, 2022 | 37 | 2022 |
| Targeting VEGF-A in myeloid cells enhances natural killer cell responses to chemotherapy and ameliorates cachexia R Klose, E Krzywinska, M Castells, D Gotthardt, EM Putz, ... Nature communications 7 (1), 12528, 2016 | 36 | 2016 |
| ImmGen at 15 SV Aguilar, O Aguilar, R Allan, EAD Amir, V Angeli, MN Artyomov, ... Nature immunology 21 (7), 700-703, 2020 | 34 | 2020 |
| In vivo tumor surveillance by NK cells requires TYK2 but not TYK2 kinase activity M Prchal-Murphy, A Witalisz-Siepracka, KT Bednarik, EM Putz, ... Oncoimmunology 4 (11), e1047579, 2015 | 34 | 2015 |
| Myeloid STAT3 promotes formation of colitis-associated colorectal cancer in mice P Pathria, D Gotthardt, M Prchal-Murphy, EM Putz, M Holcmann, ... Oncoimmunology 4 (4), e998529, 2015 | 34 | 2015 |
| Cutting edge: NKG2D signaling enhances NK cell responses but alone is insufficient to drive expansion during mouse cytomegalovirus infection T Nabekura, D Gotthardt, K Niizuma, T Trsan, T Jenus, S Jonjic, LL Lanier The Journal of Immunology 199 (5), 1567-1571, 2017 | 28 | 2017 |
| Novel non-canonical role of STAT1 in natural killer cell cytotoxicity EM Putz, A Majoros, D Gotthardt, M Prchal-Murphy, EM Zebedin-Brandl, ... Oncoimmunology 5 (9), e1186314, 2016 | 23 | 2016 |
| NK cell development in bone marrow and liver: site matters D Gotthardt, M Prchal-Murphy, C Seillet, A Glasner, O Mandelboim, ... Genes & Immunity 15 (8), 584-587, 2014 | 23 | 2014 |
| Triple-negative breast cancer cells rely on kinase-independent functions of CDK8 to evade NK-cell-mediated tumor surveillance VM Knab, D Gotthardt, K Klein, R Grausenburger, G Heller, I Menzl, ... Cell Death & Disease 12 (11), 991, 2021 | 21 | 2021 |
Veronika SexlProfessorin der Pharmakologie und Toxikologie, Vetmeduni ViennaVerified email at vetmeduni.ac.at