| Purification of a RAS-Responsive Adenylyl Cyclase Complex from Saccharomyces cerevisiae by Use of an Epitope Addition Method J Field, JI Nikawa, D Broek, B MacDonald, L Rodgers, IA Wilson, ... Molecular and cellular biology 8 (5), 2159-2165, 1988 | 1345 | 1988 |
| Schwann cells: origins and role in axonal maintenance and regeneration K Bhatheja, J Field The international journal of biochemistry & cell biology 38 (12), 1995-1999, 2006 | 419 | 2006 |
| Cloning and characterization of the high-affinity cAMP phosphodiesterase of Saccharomyces cerevisiae. P Sass, J Field, J Nikawa, T Toda, M Wigler Proceedings of the National Academy of Sciences 83 (24), 9303-9307, 1986 | 387 | 1986 |
| Pak protein kinases and their role in cancer B Dummler, K Ohshiro, R Kumar, J Field Cancer and Metastasis Reviews 28, 51-63, 2009 | 354 | 2009 |
| Cloning and characterization of CAP, the S. cerevisiae gene encoding the 70 kd adenylyl cyclase-associated protein J Field, A Vojtek, R Ballester, G Bolger, J Colicelli, K Ferguson, J Gerst, ... Cell 61 (2), 319-327, 1990 | 316 | 1990 |
| The Akt proto-oncogene links Ras to Pak and cell survival signals Y Tang, H Zhou, A Chen, RN Pittman, J Field Journal of Biological Chemistry 275 (13), 9106-9109, 2000 | 311 | 2000 |
| RAM, a gene of yeast required for a functional modification of RAS proteins and for production of mating pheromone a-factor S Powers, S Michaelis, D Broek, AAS Santa, J Field, I Herskowitz, ... Cell 47 (3), 413-422, 1986 | 299 | 1986 |
| A circadian output in Drosophila mediated by neurofibromatosis-1 and Ras/MAPK JA Williams, HS Su, A Bernards, J Field, A Sehgal Science 293 (5538), 2251-2256, 2001 | 288 | 2001 |
| PAK signaling in cancer DZ Ye, J Field Cellular logistics 2 (2), 105-116, 2012 | 278 | 2012 |
| Evidence for a functional link between profilin and CAP in the yeast S. cerevisiae A Vojtek, B Haarer, J Field, J Gerst, TD Pollard, S Brown, M Wigler Cell 66 (3), 497-505, 1991 | 255 | 1991 |
| Kinase-deficient Pak1 mutants inhibit Ras transformation of Rat-1 fibroblasts Y Tang, Z Chen, D Ambrose, J Liu, JB Gibbs, J Chernoff, J Field Molecular and cellular biology 17 (8), 4454-4464, 1997 | 252 | 1997 |
| Akt phosphorylation of serine 21 on Pak1 modulates Nck binding and cell migration GL Zhou, Y Zhuo, CC King, BH Fryer, GM Bokoch, J Field Molecular and cellular biology 23 (22), 8058-8069, 2003 | 215 | 2003 |
| CAP is a bifunctional component of the Saccharomyces cerevisiae adenylyl cyclase complex JE Gerst, K Ferguson, A Vojtek, M Wigler, J Field Molecular and cellular biology, 1991 | 206 | 1991 |
| Opposing roles for Akt1 and Akt2 in Rac/Pak signaling and cell migration GL Zhou, DF Tucker, SS Bae, K Bhatheja, MJ Birnbaum, J Field Journal of biological chemistry 281 (47), 36443-36453, 2006 | 189 | 2006 |
| A conserved proline-rich region of the Saccharomyces cerevisiae cyclase-associated protein binds SH3 domains and modulates cytoskeletal localization NL Freeman, T Lila, KA Mintzer, Z Chen, AJ Pahk, R Ren, DG Drubin, ... Molecular and cellular biology, 1996 | 184 | 1996 |
| p21-activated Kinase 1 (Pak1)-dependent phosphorylation of Raf-1 regulates its mitochondrial localization, phosphorylation of BAD, and Bcl-2 association S Jin, Y Zhuo, W Guo, J Field Journal of Biological Chemistry 280 (26), 24698-24705, 2005 | 179 | 2005 |
| An actin monomer binding activity localizes to the carboxyl-terminal half of the Saccharomyces cerevisiae cyclase-associated protein NL Freeman, Z Chen, J Horenstein, A Weber, J Field Journal of Biological Chemistry 270 (10), 5680-5685, 1995 | 177 | 1995 |
| Signals from the Ras, Rac, and Rho GTPases converge on the Pak protein kinase in Rat-1 fibroblasts Y Tang, J Yu, J Field Molecular and cellular biology 19 (3), 1881-1891, 1999 | 174 | 1999 |
| Separation of the adenovirus terminal protein precursor from its associated DNA polymerase: role of both proteins in the initiation of adenovirus DNA replication. JH Lichy, J Field, MS Horwitz, J Hurwitz Proceedings of the National Academy of Sciences 79 (17), 5225-5229, 1982 | 174 | 1982 |
| PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas H Lu, S Liu, G Zhang, B Wu, Y Zhu, DT Frederick, Y Hu, W Zhong, ... Nature 550 (7674), 133-136, 2017 | 172 | 2017 |
Randall N. PittmanProfessor of Pharmacology, University of PennsylvaniaVerified email at mail.med.upenn.edu