JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin BA Witthuhn, FW Quelle, O Silvennoinen, T Yi, B Tang, O Miura, JN Ihle Cell 74 (2), 227-236, 1993 | 1471 | 1993 |
Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 β receptor components N Stahl, TG Boulton, T Farruggella, NY Ip, S Davis, BA Witthuhn, ... Science 263 (5143), 92-95, 1994 | 1275 | 1994 |
Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase LS Argetsinger, GS Campbell, X Yang, BA Witthuhn, O Silvennoinen, ... Cell 74 (2), 237-244, 1993 | 1268 | 1993 |
The protein tyrosine kinase JAK1 complements defects in interferon-α/β and-γ signal transduction M Müller, J Briscoe, C Laxton, D Guschin, A Ziemiecki, O Silvennoinen, ... Nature 366 (6451), 129-135, 1993 | 960 | 1993 |
Signaling by the cytokine receptor superfamily: JAKs and STATs JN Ihle, BA Witthuhn, FW Quelle, K Yamamoto, WE Thierfelder, B Kreider, ... Trends in biochemical sciences 19 (5), 222-227, 1994 | 870 | 1994 |
Interaction of IL-2Rβ and γc Chains with Jak1 and Jak3: Implications for XSCID and XCID SM Russell, JA Johnston, M Noguchi, M Kawamura, CM Bacon, ... Science 266 (5187), 1042-1045, 1994 | 842 | 1994 |
Signaling through the hematopoietic cytokine receptors. JN Ihle, BA Witthuhn, FW Quelle, K Yamamoto, O Silvennoinen Annual review of immunology 13, 369-398, 1995 | 832 | 1995 |
The janus kinases (jaks) K Yamaoka, P Saharinen, M Pesu, VET Holt, O Silvennoinen, JJ O'Shea Genome biology 5, 1-6, 2004 | 830 | 2004 |
Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells BA Witthuhn, O Silvennoinen, O Miura, KS Lai, C Cwik, ET Liu, JN Ihle Nature 370 (6485), 153-157, 1994 | 775 | 1994 |
Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits T Miyazaki, A Kawahara, H Fujii, Y Nakagawa, Y Minami, ZJ Liu, I Oishi, ... Science 266 (5187), 1045-1047, 1994 | 746 | 1994 |
Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction. O Silvennoinen, BA Witthuhn, FW Quelle, JL Cleveland, T Yi, JN Ihle Proceedings of the National Academy of Sciences 90 (18), 8429-8433, 1993 | 638 | 1993 |
Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-& gamma; signal transduction pathway D Watling, D Guschin, M Müller, O Silvennoinen, BA Witthuhn, FW Quelle, ... Nature 366 (6451), 166-170, 1993 | 623 | 1993 |
Regulation of the Jak2 tyrosine kinase by its pseudokinase domain P Saharinen, K Takaluoma, O Silvennoinen Molecular and cellular biology 20 (10), 3387-3395, 2000 | 513 | 2000 |
Interferon-induced nuclear signalling by Jak protein tyrosine kinases O Silvennoinen, JN Ihle, J Schlessinger, DE Levy Nature 366 (6455), 583-585, 1993 | 496 | 1993 |
Ras-independent growth factor signaling by transcription factor tyrosine phosphorylation O Silvennoinen, C Schindler, J Schlessinger, DE Levy Science 261 (5129), 1736-1739, 1993 | 430 | 1993 |
The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction P Saharinen, O Silvennoinen Journal of Biological Chemistry 277 (49), 47954-47963, 2002 | 423 | 2002 |
Activation of JAK2 kinase mediated by the interleukin 6 signal transducer gp130. M Narazaki, BA Witthuhn, K Yoshida, O Silvennoinen, K Yasukawa, ... Proceedings of the National Academy of Sciences 91 (6), 2285-2289, 1994 | 382 | 1994 |
Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1 D Ungureanu, P Saharinen, I Junttila, DJ Hilton, O Silvennoinen Molecular and cellular biology, 2002 | 370 | 2002 |
Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture AL Lahti, VJ Kujala, H Chapman, AP Koivisto, M Pekkanen-Mattila, ... Disease models & mechanisms 5 (2), 220-230, 2012 | 367 | 2012 |
The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling D Ungureanu, J Wu, T Pekkala, Y Niranjan, C Young, ON Jensen, CF Xu, ... Nature structural & molecular biology 18 (9), 971-976, 2011 | 340 | 2011 |