| NFAT pulls the strings during CD4+ T helper cell effector functions N Hermann-Kleiter, G Baier Blood, The Journal of the American Society of Hematology 115 (15), 2989-2997, 2010 | 296 | 2010 |
| Targeting immune checkpoints potentiates immunoediting and changes the dynamics of tumor evolution M Efremova, D Rieder, V Klepsch, P Charoentong, F Finotello, H Hackl, ... Nature communications 9 (1), 32, 2018 | 293 | 2018 |
| The potent protein kinase C-selective inhibitor AEB071 (sotrastaurin) represents a new class of immunosuppressive agents affecting early T-cell activation JP Evenou, J Wagner, G Zenke, V Brinkmann, K Wagner, J Kovarik, ... Journal of Pharmacology and Experimental Therapeutics 330 (3), 792-801, 2009 | 184 | 2009 |
| NAD metabolism fuels human and mouse intestinal inflammation RR Gerner, V Klepsch, S Macheiner, K Arnhard, TE Adolph, C Grander, ... Gut 67 (10), 1813-1823, 2018 | 157 | 2018 |
| Defective IgG2a/2b class switching in PKCα−/− mice C Pfeifhofer, T Gruber, T Letschka, N Thuille, C Lutz-Nicoladoni, ... The Journal of Immunology 176 (10), 6004-6011, 2006 | 100 | 2006 |
| PKC-θ modulates the strength of T cell responses by targeting Cbl-b for ubiquitination and degradation T Gruber, N Hermann-Kleiter, R Hinterleitner, F Fresser, R Schneider, ... Science signaling 2 (76), ra30-ra30, 2009 | 95 | 2009 |
| The nuclear orphan receptor NR2F6 suppresses lymphocyte activation and T helper 17-dependent autoimmunity N Hermann-Kleiter, T Gruber, C Lutz-Nicoladoni, N Thuille, F Fresser, ... Immunity 29 (2), 205-216, 2008 | 93 | 2008 |
| PKC-θ selectively controls the adhesion-stimulating molecule Rap1 T Letschka, V Kollmann, C Pfeifhofer-Obermair, C Lutz-Nicoladoni, ... Blood, The Journal of the American Society of Hematology 112 (12), 4617-4627, 2008 | 77 | 2008 |
| Nuclear Receptors Regulate Intestinal Inflammation in the Context of IBD. HKN Klepsch V, Moschen AR, Tilg H, Baier G Frontiers in immunology 10 (1070), doi: 10.3389/fimmu.2019.01070., 2019 | 62* | 2019 |
| PKCθ cooperates with PKCα in alloimmune responses of T cells in vivo T Gruber, N Hermann-Kleiter, C Pfeifhofer-Obermair, C Lutz-Nicoladoni, ... Molecular immunology 46 (10), 2071-2079, 2009 | 60 | 2009 |
| Nuclear receptor NR2F6 inhibition potentiates responses to PD-L1/PD-1 cancer immune checkpoint blockade V Klepsch, N Hermann-Kleiter, P Do-Dinh, B Jakic, A Offermann, ... Nature communications 9 (1), 1538, 2018 | 59 | 2018 |
| The nuclear orphan receptor NR2F6 is a central checkpoint for cancer immune surveillance N Hermann-Kleiter, V Klepsch, S Wallner, K Siegmund, S Klepsch, ... Cell reports 12 (12), 2072-2085, 2015 | 53 | 2015 |
| PKCθ and PKA are antagonistic partners in the NF-AT transactivation pathway of primary mouse CD3+ T lymphocytes N Hermann-Kleiter, N Thuille, C Pfeifhofer, T Gruber, M Schäfer, C Zitt, ... Blood 107 (12), 4841-4848, 2006 | 53 | 2006 |
| Nuclear orphan receptor NR2F6 directly antagonizes NFAT and RORγt binding to the Il17a promoter N Hermann-Kleiter, M Meisel, F Fresser, N Thuille, M Müller, L Roth, ... Journal of autoimmunity 39 (4), 428-440, 2012 | 51 | 2012 |
| Coronin 1A is an essential regulator of the TGFβ receptor/SMAD3 signaling pathway in Th17 CD4+ T cells S Kaminski, N Hermann-Kleiter, M Meisel, N Thuille, S Cronin, H Hara, ... Journal of autoimmunity 37 (3), 198-208, 2011 | 44 | 2011 |
| The kinase PKCα selectively upregulates interleukin-17A during Th17 cell immune responses M Meisel, N Hermann-Kleiter, R Hinterleitner, T Gruber, K Wachowicz, ... Immunity 38 (1), 41-52, 2013 | 42 | 2013 |
| Cbl-b mediates TGFβ sensitivity by downregulating inhibitory SMAD7 in primary T cells T Gruber, R Hinterleitner, N Hermann-Kleiter, M Meisel, I Kleiter, ... Journal of molecular cell biology 5 (6), 358-368, 2013 | 38 | 2013 |
| Orphan nuclear receptor NR2F6 acts as an essential gatekeeper of Th17 CD4+ T cell effector functions N Hermann-Kleiter, G Baier Cell Communication and Signaling 12, 1-12, 2014 | 37 | 2014 |
| Nuclear orphan receptor NR2F6 as a safeguard against experimental murine colitis V Klepsch, RR Gerner, S Klepsch, WJ Olson, H Tilg, AR Moschen, G Baier, ... Gut 67 (8), 1434-1444, 2018 | 32 | 2018 |
| Loss of PIDD limits NF-κB activation and cytokine production but not cell survival or transformation after DNA damage FJ Bock, G Krumschnabel, C Manzl, L Peintner, MC Tanzer, ... Cell Death & Differentiation 20 (4), 546-557, 2013 | 32 | 2013 |
Dr. Kerstin Siegmund (Bellaire-Siegm...Cell Genetics, Med. Uni. InnsbruckVerified email at i-med.ac.at