| The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4 A Csibi, SM Fendt, C Li, G Poulogiannis, AY Choo, DJ Chapski, SM Jeong, ... Cell 153 (4), 840-854, 2013 | 711 | 2013 |
| Methionine metabolism and methyltransferases in the regulation of aging and lifespan extension across species AA Parkhitko, P Jouandin, SE Mohr, N Perrimon Aging cell 18 (6), e13034, 2019 | 234 | 2019 |
| Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent A Parkhitko, F Myachina, TA Morrison, KM Hindi, N Auricchio, ... Proceedings of the National Academy of Sciences 108 (30), 12455-12460, 2011 | 224 | 2011 |
| Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices ES Leshchiner, A Parkhitko, GH Bird, J Luccarelli, JA Bellairs, S Escudero, ... Proceedings of the National Academy of Sciences 112 (6), 1761-1766, 2015 | 191 | 2015 |
| Tissue-specific down-regulation of S-adenosyl-homocysteine via suppression of dAhcyL1/dAhcyL2 extends health span and life span in Drosophila AA Parkhitko, R Binari, N Zhang, JM Asara, F Demontis, N Perrimon Genes & development 30 (12), 1409-1422, 2016 | 98 | 2016 |
| Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells C Li, PS Lee, Y Sun, X Gu, E Zhang, Y Guo, CL Wu, N Auricchio, C Priolo, ... Journal of Experimental Medicine 211 (1), 15-28, 2014 | 84 | 2014 |
| Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide AA Parkhitko, C Priolo, JL Coloff, J Yun, JJ Wu, K Mizumura, W Xu, ... Molecular Cancer Research 12 (1), 48-57, 2014 | 71 | 2014 |
| Mammalian target of rapamycin signaling and autophagy: roles in lymphangioleiomyomatosis therapy J Yu, AA Parkhitko, EP Henske Proceedings of the American Thoracic Society 7 (1), 48-53, 2010 | 71 | 2010 |
| ARDD 2020: from aging mechanisms to interventions GV Mkrtchyan, K Abdelmohsen, P Andreux, I Bagdonaite, N Barzilai, ... Aging (Albany NY) 12 (24), 24484, 2020 | 66 | 2020 |
| Interaction of Epstein-Barr virus latent membrane protein 1 with SCFHOS/β-TrCP E3 ubiquitin ligase regulates extent of NF-κB activation W Tang, OA Pavlish, VS Spiegelman, AA Parkhitko, SY Fuchs Journal of Biological Chemistry 278 (49), 48942-48949, 2003 | 66 | 2003 |
| Targeting metabolic pathways for extension of lifespan and healthspan across multiple species AA Parkhitko, E Filine, SE Mohr, A Moskalev, N Perrimon Ageing Research Reviews 64, 101188, 2020 | 61 | 2020 |
| Folliculin regulates cell–cell adhesion, AMPK, and mTORC1 in a cell‐type‐specific manner in lung‐derived cells D Khabibullin, DA Medvetz, M Pinilla, V Hariharan, C Li, A Hergrueter, ... Physiological reports 2 (8), e12107, 2014 | 61 | 2014 |
| p62/SQSTM1 cooperates with hyperactive mTORC1 to regulate glutathione production, maintain mitochondrial integrity, and promote tumorigenesis HC Lam, CV Baglini, AL Lope, AA Parkhitko, HJ Liu, N Alesi, ... Cancer research 77 (12), 3255-3267, 2017 | 59 | 2017 |
| Lysosomal cystine mobilization shapes the response of TORC1 and tissue growth to fasting P Jouandin, Z Marelja, YH Shih, AA Parkhitko, M Dambowsky, JM Asara, ... Science 375 (6582), eabc4203, 2022 | 51 | 2022 |
| Kinase mTOR: regulation and role in maintenance of cellular homeostasis, tumor development, and aging AA Parkhitko, OO Favorova, DI Khabibullin, VN Anisimov, EP Henske Biochemistry (Moscow) 79, 88-101, 2014 | 50 | 2014 |
| Faslodex inhibits estradiol-induced extracellular matrix dynamics and lung metastasis in a model of lymphangioleiomyomatosis C Li, X Zhou, Y Sun, E Zhang, JD Mancini, A Parkhitko, TA Morrison, ... American journal of respiratory cell and molecular biology 49 (1), 135-142, 2013 | 49 | 2013 |
| Autophagy: mechanisms, regulation, and its role in tumorigenesis AA Parkhitko, OO Favorova, EP Henske Biochemistry (Moscow) 78, 355-367, 2013 | 47 | 2013 |
| Autophagy: an'Achilles' heel of tumorigenesis in TSC and LAM J Yu, A Parkhitko, EP Henske Autophagy 7 (11), 1400-1401, 2011 | 47 | 2011 |
| Blocking p62-dependent SMN degradation ameliorates spinal muscular atrophy disease phenotypes N Rodriguez-Muela, A Parkhitko, T Grass, RM Gibbs, EM Norabuena, ... The Journal of Clinical Investigation 128 (7), 3008-3023, 2018 | 44 | 2018 |
| Downregulation of the tyrosine degradation pathway extends Drosophila lifespan AA Parkhitko, D Ramesh, L Wang, D Leshchiner, E Filine, R Binari, ... Elife 9, e58053, 2020 | 36 | 2020 |