| ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A CT Williamson, R Miller, HN Pemberton, SE Jones, J Campbell, A Konde, ... Nature communications 7 (1), 1-13, 2016 | 357 | 2016 |
| Hierarchical modularity and the evolution of genetic interactomes across species CJ Ryan, A Roguev, K Patrick, J Xu, H Jahari, Z Tong, P Beltrao, M Shales, ... Molecular cell 46 (5), 691-704, 2012 | 239 | 2012 |
| Cells lacking the RB1 tumor suppressor gene are hyperdependent on Aurora B kinase for survival MG Oser, R Fonseca, AA Chakraborty, R Brough, A Spektor, RB Jennings, ... Cancer discovery 9 (2), 230-247, 2019 | 157 | 2019 |
| Large-scale profiling of kinase dependencies in cancer cell lines J Campbell, CJ Ryan, R Brough, I Bajrami, HN Pemberton, IY Chong, ... Cell reports 14 (10), 2490-2501, 2016 | 125 | 2016 |
| E-cadherin/ROS1 inhibitor synthetic lethality in breast cancer I Bajrami, R Marlow, M van de Ven, R Brough, HN Pemberton, J Frankum, ... Cancer discovery 8 (4), 498-515, 2018 | 124 | 2018 |
| Synthetic lethality and cancer–penetrance as the major barrier CJ Ryan, I Bajrami, CJ Lord Trends in cancer 4 (10), 671-683, 2018 | 97 | 2018 |
| High-resolution network biology: connecting sequence with function CJ Ryan, P Cimermančič, ZA Szpiech, A Sali, RD Hernandez, NJ Krogan Nature Reviews Genetics 14 (12), 865-879, 2013 | 94 | 2013 |
| The yeast SR-like protein Npl3 links chromatin modification to mRNA processing EA Moehle, CJ Ryan, NJ Krogan, TL Kress, C Guthrie PLoS genetics 8 (11), e1003101, 2012 | 82 | 2012 |
| Paralog buffering contributes to the variable essentiality of genes in cancer cell lines B De Kegel, CJ Ryan PLoS genetics 15 (10), e1008466, 2019 | 80 | 2019 |
| Comprehensive prediction of robust synthetic lethality between paralog pairs in cancer cell lines B De Kegel, N Quinn, NA Thompson, DJ Adams, CJ Ryan Cell Systems 12 (12), 1144-1159. e6, 2021 | 65 | 2021 |
| Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D SA Kennedy, MA Jarboui, S Srihari, C Raso, K Bryan, L Dernayka, ... Nature communications 11 (1), 1-14, 2020 | 61 | 2020 |
| Systematic triple-mutant analysis uncovers functional connectivity between pathways involved in chromosome regulation JE Haber, H Braberg, Q Wu, R Alexander, J Haase, C Ryan, ... Cell reports 3 (6), 2168-2178, 2013 | 53 | 2013 |
| A compendium of co-regulated protein complexes in breast cancer reveals collateral loss events CJ Ryan, S Kennedy, I Bajrami, D Matallanas, CJ Lord Cell systems 5 (4), 399-409. e5, 2017 | 49 | 2017 |
| Integrative analysis of large-scale loss-of-function screens identifies robust cancer-associated genetic interactions CJ Lord, N Quinn, CJ Ryan Elife 9, e58925, 2020 | 47 | 2020 |
| All or nothing: protein complexes flip essentiality between distantly related eukaryotes CJ Ryan, NJ Krogan, P Cunningham, G Cagney Genome biology and evolution 5 (6), 1049-1059, 2013 | 45 | 2013 |
| Key functional regions in the histone variant H2A. Z C-terminal docking domain AY Wang, MJ Aristizabal, C Ryan, NJ Krogan, MS Kobor Molecular and cellular biology 31 (18), 3871-3884, 2011 | 42 | 2011 |
| Chemical genetics of rapamycin-insensitive TORC2 in S. cerevisiae JI Kliegman, D Fiedler, CJ Ryan, YF Xu, X Su, D Thomas, MC Caccese, ... Cell reports 5 (6), 1725-1736, 2013 | 40 | 2013 |
| Experimental reproducibility limits the correlation between mRNA and protein abundances in tumor proteomic profiles SR Upadhya, CJ Ryan Cell Reports Methods, 100288, 2022 | 36 | 2022 |
| Genetic interaction mapping reveals a role for the SWI/SNF nucleosome remodeler in spliceosome activation in fission yeast KL Patrick, CJ Ryan, J Xu, JJ Lipp, KE Nissen, A Roguev, M Shales, ... PLoS genetics 11 (3), e1005074, 2015 | 35 | 2015 |
| DAISY: picking synthetic lethals from cancer genomes CJ Ryan, CJ Lord, A Ashworth Cancer cell 26 (3), 306-308, 2014 | 35 | 2014 |