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Austin E. Y. T. Lefebvre, Ph.D.
Austin E. Y. T. Lefebvre, Ph.D.
Data Scientist at Calico Life Sciences
Verified email at calicolabs.com - Homepage
Title
Cited by
Cited by
Year
Transcriptional diversity and bioenergetic shift in human breast cancer metastasis revealed by single-cell RNA sequencing
RT Davis, K Blake, D Ma, MBI Gabra, GA Hernandez, AT Phung, Y Yang, ...
Nature cell biology 22 (3), 310-320, 2020
2572020
Automated segmentation and tracking of mitochondria in live-cell time-lapse images
AEYT Lefebvre, D Ma, K Kessenbrock, DA Lawson, MA Digman
Nature Methods 18 (9), 1091-1102, 2021
882021
Collagen density modulates triple-negative breast cancer cell metabolism through adhesion-mediated contractility
EJ Mah, AEYT Lefebvre, GE McGahey, AF Yee, MA Digman
Scientific reports 8 (1), 17094, 2018
752018
LKB1 promotes metabolic flexibility in response to energy stress
SJ Parker, RU Svensson, AS Divakaruni, AE Lefebvre, AN Murphy, ...
Metabolic engineering 43, 208-217, 2017
612017
Disruption of the circadian clock drives Apc loss of heterozygosity to accelerate colorectal cancer
SK Chun, BM Fortin, RC Fellows, AN Habowski, A Verlande, WA Song, ...
Science advances 8 (31), eabo2389, 2022
512022
Microenvironmental stiffness induces metabolic reprogramming in glioblastoma
A Sohrabi, AEYT Lefebvre, MJ Harrison, MC Condro, TM Sanazzaro, ...
Cell reports 42 (10), 2023
232023
The actin binding protein profilin 1 is critical for mitochondria function
TA Read, BA Cisterna, K Skruber, S Ahmadieh, HL Lindamood, JA Vitriol, ...
BioRxiv, 2023
92023
Patient-derived xenograft culture-transplant system for investigation of human breast cancer metastasis
D Ma, GA Hernandez, AEYT Lefebvre, H Alshetaiwi, K Blake, KR Dave, ...
Communications biology 4 (1), 1268, 2021
92021
Nellie: Automated organelle segmentation, tracking, and hierarchical feature extraction in 2D/3D live-cell microscopy
AEYT Lefebvre, G Sturm, TY Lin, E Stoops, MP Lopez, ...
arXiv preprint arXiv:2403.13214, 2024
32024
The microenvironment dictates glycocalyx construction and immune surveillance
KM Tharp, S Park, GA Timblin, AL Richards, JA Berg, NM Twells, ...
Research Square, 2023
32023
Specific activation of the integrated stress response uncovers regulation of central carbon metabolism and lipid droplet biogenesis
K Labbé, L LeBon, B King, N Vu, EH Stoops, N Ly, AEYT Lefebvre, ...
Nature Communications 15 (1), 8301, 2024
12024
The actin binding protein profilin 1 localizes inside mitochondria and is critical for their function
TA Read, BA Cisterna, K Skruber, S Ahmadieh, TM Liu, JA Vitriol, Y Shi, ...
EMBO reports 25 (8), 3240-3262, 2024
12024
Fluorescence Lifetime Imaging Microscopy (FLIM) visualizes internalization and biological impact of nanoplastics in live intestinal organoids
IA Okkelman, H Zhou, SM Borisov, AC Debruyne, AEYT Lefebvre, ...
bioRxiv, 2025.01. 27.635069, 2025
2025
Morphological and genetic screens reveal mechanisms of BiDAC-induced plasma membrane protein degradation
K Bersuker, Q Jafri, J Lazzari-Dean, M Sangha, S Villa, A Lefebvre, ...
2024
Metabolic profiling and tracking phenotypic changes in mitochondria in cancer cells with mitometer and the phasor approach to FLIM
MA Digman, G Tedeschi, L Scipioni, AE Lefebvre, F Palomba
Biophysical Journal 123 (3), 36a, 2024
2024
The biophysical mechanism of mitochondrial pearling
G Sturm, K Hake, AEYT Lefebvre, CJ Rux, D Ivanova, A Millett-Sikking, ...
bioRxiv, 2024.12. 21.629509, 2024
2024
From cameras to confocal to cytometry: measuring tumbling rates is a general way to reveal protein binding
AGY Julia R Lazzari-Dean, Austin EYT Lefebvre, Rebecca Frank Hayward ...
10.5281/zenodo.10028432, 2023
2023
BIOMIMETIC HYALURONIC ACID-BASED HYDROGELS TO INVESTIGATE ROLE OF TUMOR BIOPHYSICAL PROPERTIES ON GLIOBLASTOMA (GBM) PROGRESSION
A Sohrabi, J Liang, A Lefebvre, M Condro, H Kornblum, M Digman, ...
TISSUE ENGINEERING PART A 28, S517-S517, 2022
2022
Effects Of Matrix Stiffness On Glioblastoma Metabolism
SK Seidlits, A Sohrabi, A Lefebvre, M Condro, HI Kornblum, MA Digman
2022
TRACKING MITOCHONDRIA REVEALS METABOLIC AND DYNAMIC HETEROGENEITY IN BREAST CANCERS
AEYT Lefebvre
2021 Annual Meeting, 2021
2021
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Articles 1–20