| The phosphatidylinositol 3-kinase–AKT pathway in human cancer I Vivanco, CL Sawyers Nature Reviews Cancer 2 (7), 489-501, 2002 | 7863 | 2002 |
| Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia BJ Druker, M Talpaz, DJ Resta, B Peng, E Buchdunger, JM Ford, ... New England Journal of Medicine 344 (14), 1031-1037, 2001 | 6881 | 2001 |
| Integrative genomic profiling of human prostate cancer BS Taylor, N Schultz, H Hieronymus, A Gopalan, Y Xiao, BS Carver, ... Cancer cell 18 (1), 11-22, 2010 | 4174 | 2010 |
| Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification ME Gorre, M Mohammed, K Ellwood, N Hsu, R Paquette, PN Rao, ... Science 293 (5531), 876-880, 2001 | 4109 | 2001 |
| Integrative clinical genomics of advanced prostate cancer D Robinson, EM Van Allen, YM Wu, N Schultz, RJ Lonigro, JM Mosquera, ... Cell 161 (5), 1215-1228, 2015 | 3960 | 2015 |
| Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome BJ Druker, CL Sawyers, H Kantarjian, DJ Resta, SF Reese, JM Ford, ... New England Journal of Medicine 344 (14), 1038-1042, 2001 | 3597 | 2001 |
| Molecular determinants of resistance to antiandrogen therapy CD Chen, DS Welsbie, C Tran, SH Baek, R Chen, R Vessella, ... Nature medicine 10 (1), 33-39, 2004 | 2906 | 2004 |
| Development of a second-generation antiandrogen for treatment of advanced prostate cancer C Tran, S Ouk, NJ Clegg, Y Chen, PA Watson, V Arora, J Wongvipat, ... Science 324 (5928), 787-790, 2009 | 2753 | 2009 |
| Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia H Kantarjian, C Sawyers, A Hochhaus, F Guilhot, C Schiffer, ... New England Journal of Medicine 346 (9), 645-652, 2002 | 2731 | 2002 |
| Overriding imatinib resistance with a novel ABL kinase inhibitor NP Shah, C Tran, FY Lee, P Chen, D Norris, CL Sawyers Science 305 (5682), 399-401, 2004 | 2348 | 2004 |
| Dasatinib in imatinib-resistant Philadelphia chromosome–positive leukemias M Talpaz, NP Shah, H Kantarjian, N Donato, J Nicoll, R Paquette, ... New England Journal of Medicine 354 (24), 2531-2541, 2006 | 2214 | 2006 |
| Chronic myeloid leukemia CL Sawyers New England Journal of Medicine 340 (17), 1330-1340, 1999 | 2154 | 1999 |
| Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia NP Shah, JM Nicoll, B Nagar, ME Gorre, RL Paquette, J Kuriyan, ... Cancer cell 2 (2), 117-125, 2002 | 2095 | 2002 |
| Granulocyte–macrophage progenitors as candidate leukemic stem cells in blast-crisis CML CHM Jamieson, LE Ailles, SJ Dylla, M Muijtjens, C Jones, JL Zehnder, ... New England Journal of Medicine 351 (7), 657-667, 2004 | 1901 | 2004 |
| Inherited DNA-repair gene mutations in men with metastatic prostate cancer CC Pritchard, J Mateo, MF Walsh, N De Sarkar, W Abida, H Beltran, ... New England Journal of Medicine 375 (5), 443-453, 2016 | 1754 | 2016 |
| Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors IK Mellinghoff, MY Wang, I Vivanco, DA Haas-Kogan, S Zhu, EQ Dia, ... New England Journal of Medicine 353 (19), 2012-2024, 2005 | 1741 | 2005 |
| Targeted cancer therapy C Sawyers Nature 432 (7015), 294-297, 2004 | 1612 | 2004 |
| Organoid cultures derived from patients with advanced prostate cancer D Gao, I Vela, A Sboner, PJ Iaquinta, WR Karthaus, A Gopalan, ... Cell 159 (1), 176-187, 2014 | 1584 | 2014 |
| Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results of a phase II study: Presented in part at … CL Sawyers, A Hochhaus, E Feldman, JM Goldman, CB Miller, ... Blood, The Journal of the American Society of Hematology 99 (10), 3530-3539, 2002 | 1540 | 2002 |
| Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: results of a phase 2 study M Talpaz, RT Silver, BJ Druker, JM Goldman, C Gambacorti-Passerini, ... Blood, The Journal of the American Society of Hematology 99 (6), 1928-1937, 2002 | 1482 | 2002 |
