| Potent and selective antisense oligonucleotides targeting single-nucleotide polymorphisms in the Huntington disease gene/allele-specific silencing of mutant huntingtin JB Carroll, SC Warby, AL Southwell, CN Doty, S Greenlee, N Skotte, ... Molecular Therapy 19 (12), 2178-2185, 2011 | 332 | 2011 |
| Site-specific characterization of endogenous SUMOylation across species and organs IA Hendriks, D Lyon, D Su, NH Skotte, JA Daniel, LJ Jensen, ML Nielsen Nature communications 9 (1), 2456, 2018 | 197 | 2018 |
| Rational design of antisense oligonucleotides targeting single nucleotide polymorphisms for potent and allele selective suppression of mutant Huntingtin in the CNS ME Østergaard, AL Southwell, H Kordasiewicz, AT Watt, NH Skotte, ... Nucleic acids research 41 (21), 9634-9650, 2013 | 187 | 2013 |
| In vivo evaluation of candidate allele-specific mutant huntingtin gene silencing antisense oligonucleotides AL Southwell, NH Skotte, HB Kordasiewicz, ME Østergaard, AT Watt, ... Molecular Therapy 22 (12), 2093-2106, 2014 | 170 | 2014 |
| Antisense oligonucleotide therapeutics for inherited neurodegenerative diseases AL Southwell, NH Skotte, CF Bennett, MR Hayden Trends in molecular medicine 18 (11), 634-643, 2012 | 166 | 2012 |
| Allele-specific suppression of mutant huntingtin using antisense oligonucleotides: providing a therapeutic option for all Huntington disease patients NH Skotte, AL Southwell, ME Østergaard, JB Carroll, SC Warby, CN Doty, ... PloS one 9 (9), e107434, 2014 | 161 | 2014 |
| Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression MA Pouladi, Y Xie, NH Skotte, DE Ehrnhoefer, RK Graham, JE Kim, ... Human molecular genetics 19 (8), 1528-1538, 2010 | 144 | 2010 |
| Huntingtin suppression restores cognitive function in a mouse model of Huntington’s disease AL Southwell, HB Kordasiewicz, D Langbehn, NH Skotte, MP Parsons, ... Science translational medicine 10 (461), eaar3959, 2018 | 133 | 2018 |
| A fully humanized transgenic mouse model of Huntington disease AL Southwell, SC Warby, JB Carroll, CN Doty, NH Skotte, W Zhang, ... Human molecular genetics 22 (1), 18-34, 2013 | 129 | 2013 |
| Huntingtin haplotypes provide prioritized target panels for allele-specific silencing in Huntington disease patients of European ancestry C Kay, JA Collins, NH Skotte, AL Southwell, SC Warby, NS Caron, ... Molecular Therapy 23 (11), 1759-1771, 2015 | 120 | 2015 |
| HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response B Rotblat, AL Southwell, DE Ehrnhoefer, NH Skotte, M Metzler, ... Proceedings of the National Academy of Sciences 111 (8), 3032-3037, 2014 | 111 | 2014 |
| Integrative characterization of the R6/2 mouse model of Huntington’s disease reveals dysfunctional astrocyte metabolism NH Skotte, JV Andersen, A Santos, BI Aldana, CW Willert, A Nørremølle, ... Cell reports 23 (7), 2211-2224, 2018 | 87 | 2018 |
| Personalized gene silencing therapeutics for Huntington disease C Kay, NH Skotte, AL Southwell, MR Hayden Clinical genetics 86 (1), 29-36, 2014 | 82 | 2014 |
| Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice V Uribe, BKY Wong, RK Graham, CL Cusack, NH Skotte, MA Pouladi, ... Human molecular genetics 21 (9), 1954-1967, 2012 | 81 | 2012 |
| Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimer’s disease JV Andersen, NH Skotte, SK Christensen, FS Polli, M Shabani, ... Cell Death & Disease 12 (11), 954, 2021 | 66 | 2021 |
| Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington disease DE Ehrnhoefer, DDO Martin, ME Schmidt, X Qiu, S Ladha, NS Caron, ... Acta neuropathologica communications 6 (1), 16, 2018 | 66 | 2018 |
| p53 increases caspase-6 expression and activation in muscle tissue expressing mutant huntingtin DE Ehrnhoefer, NH Skotte, S Ladha, YTN Nguyen, X Qiu, Y Deng, ... Human molecular genetics 23 (3), 717-729, 2014 | 60 | 2014 |
| Reduced gluconeogenesis and lactate clearance in Huntington's disease K Josefsen, SMB Nielsen, A Campos, T Seifert, L Hasholt, JE Nielsen, ... Neurobiology of disease 40 (3), 656-662, 2010 | 45 | 2010 |
| A novel humanized mouse model of Huntington disease for preclinical development of therapeutics targeting mutant huntingtin alleles AL Southwell, NH Skotte, EB Villanueva, ME Østergaard, X Gu, ... Human Molecular Genetics 26 (6), 1115-1132, 2017 | 44 | 2017 |
| Integrative analysis identifies key molecular signatures underlying neurodevelopmental deficits in fragile X syndrome KH Utami, NH Skotte, AR Colaço, NABM Yusof, B Sim, XY Yeo, HG Bae, ... Biological Psychiatry 88 (6), 500-511, 2020 | 42 | 2020 |
Michael HaydenKillam Professor, University of British ColumbiaVerified email at cmmt.ubc.ca