Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure S Shah, A Henry, C Roselli, H Lin, G Sveinbjörnsson, G Fatemifar, ... Nature communications 11 (1), 163, 2020 | 693 | 2020 |
The druggable genome and support for target identification and validation in drug development C Finan, A Gaulton, FA Kruger, RT Lumbers, T Shah, J Engmann, ... Science translational medicine 9 (383), eaag1166, 2017 | 663 | 2017 |
Evidence-based assessment of genes in dilated cardiomyopathy E Jordan, L Peterson, T Ai, B Asatryan, L Bronicki, E Brown, R Celeghin, ... Circulation 144 (1), 7-19, 2021 | 366 | 2021 |
2024 ESC Guidelines for the management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS) Developed by the task … IC Van Gelder, M Rienstra, KV Bunting, R Casado-Arroyo, V Caso, ... European Heart Journal, ehae176, 2024 | 291 | 2024 |
A chronological map of 308 physical and mental health conditions from 4 million individuals in the English National Health Service V Kuan, S Denaxas, A Gonzalez-Izquierdo, K Direk, O Bhatti, S Husain, ... The Lancet Digital Health 1 (2), e63-e77, 2019 | 289 | 2019 |
Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect R Tadros, C Francis, X Xu, AMC Vermeer, AR Harper, R Huurman, ... Nature genetics 53 (2), 128-134, 2021 | 229 | 2021 |
Beta‐blockers and inhibitors of the renin‐angiotensin aldosterone system for chronic heart failure with preserved ejection fraction N Martin, K Manoharan, C Davies, RT Lumbers Cochrane Database of Systematic Reviews, 2021 | 182 | 2021 |
PDGFRα demarcates the cardiogenic clonogenic Sca1+ stem/progenitor cell in adult murine myocardium M Noseda, M Harada, S McSweeney, T Leja, E Belian, DJ Stuckey, ... Nature communications 6 (1), 6930, 2015 | 172 | 2015 |
Genetic and functional insights into the fractal structure of the heart HV Meyer, TJW Dawes, M Serrani, W Bai, P Tokarczuk, J Cai, ... Nature 584 (7822), 589-594, 2020 | 131 | 2020 |
Therapeutic targets for heart failure identified using proteomics and Mendelian randomization A Henry, M Gordillo-Marañón, C Finan, AF Schmidt, JP Ferreira, R Karra, ... Circulation 145 (16), 1205-1217, 2022 | 113 | 2022 |
CODE-EHR best-practice framework for the use of structured electronic health-care records in clinical research D Kotecha, FW Asselbergs, S Achenbach, SD Anker, D Atar, C Baigent, ... The Lancet Digital Health 4 (10), e757-e764, 2022 | 94 | 2022 |
Identifying adults at high-risk for change in weight and BMI in England: a longitudinal, large-scale, population-based cohort study using electronic health records M Katsoulis, AG Lai, K Diaz-Ordaz, M Gomes, L Pasea, A Banerjee, ... The Lancet Diabetes & Endocrinology 9 (10), 681-694, 2021 | 84 | 2021 |
Machine learning for subtype definition and risk prediction in heart failure, acute coronary syndromes and atrial fibrillation: systematic review of validity and clinical utility A Banerjee, S Chen, G Fatemifar, M Zeina, RT Lumbers, J Mielke, S Gill, ... BMC medicine 19, 1-14, 2021 | 66 | 2021 |
Transferability of genetic loci and polygenic scores for cardiometabolic traits in British Pakistani and Bangladeshi individuals QQ Huang, N Sallah, D Dunca, B Trivedi, KA Hunt, S Hodgson, ... Nature communications 13 (1), 4664, 2022 | 51 | 2022 |
Integrating polygenic risk scores in the prediction of type 2 diabetes risk and subtypes in British Pakistanis and Bangladeshis: A population-based cohort study S Hodgson, QQ Huang, N Sallah, Genes & Health Research Team, ... PLoS medicine 19 (5), e1003981, 2022 | 41 | 2022 |
Data-driven identification of ageing-related diseases from electronic health records V Kuan, HC Fraser, M Hingorani, S Denaxas, A Gonzalez-Izquierdo, ... Scientific reports 11 (1), 2938, 2021 | 33 | 2021 |
Weight change and the onset of cardiovascular diseases: emulating trials using electronic health records M Katsoulis, BD Stavola, K Diaz-Ordaz, M Gomes, A Lai, P Lagiou, ... Epidemiology 32 (5), 744-755, 2021 | 32 | 2021 |
Transforming and evaluating electronic health record disease phenotyping algorithms using the OMOP common data model: a case study in heart failure V Papez, M Moinat, S Payralbe, FW Asselbergs, RT Lumbers, ... JAMIA open 4 (3), ooab001, 2021 | 29 | 2021 |
H3K27ac acetylome signatures reveal the epigenomic reorganization in remodeled non-failing human hearts J Pei, M Harakalova, TA Treibel, RT Lumbers, BJ Boukens, IR Efimov, ... Clinical epigenetics 12, 1-18, 2020 | 28 | 2020 |
Genetic and environmental determinants of diastolic heart function M Thanaj, J Mielke, KA McGurk, W Bai, N Savioli, A de Marvao, HV Meyer, ... Nature cardiovascular research 1 (4), 361-371, 2022 | 24 | 2022 |