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R. Thomas Lumbers
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Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure
S Shah, A Henry, C Roselli, H Lin, G Sveinbjörnsson, G Fatemifar, ...
Nature communications 11 (1), 163, 2020
6932020
The druggable genome and support for target identification and validation in drug development
C Finan, A Gaulton, FA Kruger, RT Lumbers, T Shah, J Engmann, ...
Science translational medicine 9 (383), eaag1166, 2017
6632017
Evidence-based assessment of genes in dilated cardiomyopathy
E Jordan, L Peterson, T Ai, B Asatryan, L Bronicki, E Brown, R Celeghin, ...
Circulation 144 (1), 7-19, 2021
3662021
2024 ESC Guidelines for the management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS) Developed by the task …
IC Van Gelder, M Rienstra, KV Bunting, R Casado-Arroyo, V Caso, ...
European Heart Journal, ehae176, 2024
2912024
A chronological map of 308 physical and mental health conditions from 4 million individuals in the English National Health Service
V Kuan, S Denaxas, A Gonzalez-Izquierdo, K Direk, O Bhatti, S Husain, ...
The Lancet Digital Health 1 (2), e63-e77, 2019
2892019
Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect
R Tadros, C Francis, X Xu, AMC Vermeer, AR Harper, R Huurman, ...
Nature genetics 53 (2), 128-134, 2021
2292021
Beta‐blockers and inhibitors of the renin‐angiotensin aldosterone system for chronic heart failure with preserved ejection fraction
N Martin, K Manoharan, C Davies, RT Lumbers
Cochrane Database of Systematic Reviews, 2021
1822021
PDGFRα demarcates the cardiogenic clonogenic Sca1+ stem/progenitor cell in adult murine myocardium
M Noseda, M Harada, S McSweeney, T Leja, E Belian, DJ Stuckey, ...
Nature communications 6 (1), 6930, 2015
1722015
Genetic and functional insights into the fractal structure of the heart
HV Meyer, TJW Dawes, M Serrani, W Bai, P Tokarczuk, J Cai, ...
Nature 584 (7822), 589-594, 2020
1312020
Therapeutic targets for heart failure identified using proteomics and Mendelian randomization
A Henry, M Gordillo-Marañón, C Finan, AF Schmidt, JP Ferreira, R Karra, ...
Circulation 145 (16), 1205-1217, 2022
1132022
CODE-EHR best-practice framework for the use of structured electronic health-care records in clinical research
D Kotecha, FW Asselbergs, S Achenbach, SD Anker, D Atar, C Baigent, ...
The Lancet Digital Health 4 (10), e757-e764, 2022
942022
Identifying adults at high-risk for change in weight and BMI in England: a longitudinal, large-scale, population-based cohort study using electronic health records
M Katsoulis, AG Lai, K Diaz-Ordaz, M Gomes, L Pasea, A Banerjee, ...
The Lancet Diabetes & Endocrinology 9 (10), 681-694, 2021
842021
Machine learning for subtype definition and risk prediction in heart failure, acute coronary syndromes and atrial fibrillation: systematic review of validity and clinical utility
A Banerjee, S Chen, G Fatemifar, M Zeina, RT Lumbers, J Mielke, S Gill, ...
BMC medicine 19, 1-14, 2021
662021
Transferability of genetic loci and polygenic scores for cardiometabolic traits in British Pakistani and Bangladeshi individuals
QQ Huang, N Sallah, D Dunca, B Trivedi, KA Hunt, S Hodgson, ...
Nature communications 13 (1), 4664, 2022
512022
Integrating polygenic risk scores in the prediction of type 2 diabetes risk and subtypes in British Pakistanis and Bangladeshis: A population-based cohort study
S Hodgson, QQ Huang, N Sallah, Genes & Health Research Team, ...
PLoS medicine 19 (5), e1003981, 2022
412022
Data-driven identification of ageing-related diseases from electronic health records
V Kuan, HC Fraser, M Hingorani, S Denaxas, A Gonzalez-Izquierdo, ...
Scientific reports 11 (1), 2938, 2021
332021
Weight change and the onset of cardiovascular diseases: emulating trials using electronic health records
M Katsoulis, BD Stavola, K Diaz-Ordaz, M Gomes, A Lai, P Lagiou, ...
Epidemiology 32 (5), 744-755, 2021
322021
Transforming and evaluating electronic health record disease phenotyping algorithms using the OMOP common data model: a case study in heart failure
V Papez, M Moinat, S Payralbe, FW Asselbergs, RT Lumbers, ...
JAMIA open 4 (3), ooab001, 2021
292021
H3K27ac acetylome signatures reveal the epigenomic reorganization in remodeled non-failing human hearts
J Pei, M Harakalova, TA Treibel, RT Lumbers, BJ Boukens, IR Efimov, ...
Clinical epigenetics 12, 1-18, 2020
282020
Genetic and environmental determinants of diastolic heart function
M Thanaj, J Mielke, KA McGurk, W Bai, N Savioli, A de Marvao, HV Meyer, ...
Nature cardiovascular research 1 (4), 361-371, 2022
242022
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