Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2 A Kobayashi, MI Kang, H Okawa, M Ohtsuji, Y Zenke, T Chiba, K Igarashi, ... Molecular and cellular biology 24 (16), 7130-7139, 2004 | 2537 | 2004 |
Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers N Wakabayashi, AT Dinkova-Kostova, WD Holtzclaw, MI Kang, ... Proceedings of the National Academy of Sciences 101 (7), 2040-2045, 2004 | 1180 | 2004 |
Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1 A Kobayashi, MI Kang, Y Watai, KI Tong, T Shibata, K Uchida, ... Molecular and cellular biology 26 (1), 221-229, 2006 | 1101 | 2006 |
Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer B Padmanabhan, KI Tong, T Ohta, Y Nakamura, M Scharlock, M Ohtsuji, ... Molecular cell 21 (5), 689-700, 2006 | 852 | 2006 |
Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes MI Kang, A Kobayashi, N Wakabayashi, SG Kim, M Yamamoto Proceedings of the National Academy of Sciences 101 (7), 2046-2051, 2004 | 691 | 2004 |
Differential responses of the Nrf2-Keap1 system to laminar and oscillatory shear stresses in endothelial cells T Hosoya, A Maruyama, MI Kang, Y Kawatani, T Shibata, K Uchida, K Itoh, ... Journal of Biological Chemistry 280 (29), 27244-27250, 2005 | 274 | 2005 |
Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome Y Katoh, K Iida, MIL Kang, A Kobayashi, M Mizukami, KI Tong, ... Archives of biochemistry and biophysics 433 (2), 342-350, 2005 | 264 | 2005 |
Effects of meal timing on postprandial glucose metabolism and blood metabolites in healthy adults M Takahashi, M Ozaki, MI Kang, H Sasaki, M Fukazawa, T Iwakami, ... Nutrients 10 (11), 1763, 2018 | 91 | 2018 |
Targeting of noncanonical Wnt5a signaling by AP-1 blocker dominant-negative Jun when it inhibits skin carcinogenesis MIL Kang, AR Baker, CR Dextras, SM Cabarcas, MR Young, NH Colburn Genes & cancer 3 (1), 37-50, 2012 | 37 | 2012 |
Quassinoid inhibition of AP-1 function does not correlate with cytotoxicity or protein synthesis inhibition JA Beutler, MI Kang, F Robert, JA Clement, J Pelletier, NH Colburn, ... Journal of natural products 72 (3), 503-506, 2009 | 36 | 2009 |
Microwave-Based Reaction Screening: Tandem Retro-Diels–Alder/Diels–Alder Cycloadditions of o-Quinol Dimers S Dong, KJ Cahill, MI Kang, NH Colburn, CJ Henrich, JA Wilson, ... The Journal of organic chemistry 76 (21), 8944-8954, 2011 | 30 | 2011 |
Tryptophan metabolism regulates proliferative capacity of human pluripotent stem cells S Someya, S Tohyama, K Kameda, S Tanosaki, Y Morita, K Sasaki, ... IScience 24 (2), 2021 | 26 | 2021 |
A selective small-molecule nuclear factor-κB inhibitor from a high-throughput cell-based assay for “activator protein-1 hits” MI Kang, CJ Henrich, HR Bokesch, KR Gustafson, JB McMahon, ... Molecular cancer therapeutics 8 (3), 571-581, 2009 | 21 | 2009 |
Purification, crystallization and preliminary X-ray diffraction analysis of the Kelch-like motif region of mouse Keap1 B Padmanabhan, M Scharlock, KI Tong, Y Nakamura, MI Kang, ... Acta Crystallographica Section F: Structural Biology and Crystallization …, 2005 | 21 | 2005 |
Capillary electrophoresis mass spectrometry-based metabolomics of plasma samples from healthy subjects in a cross-sectional Japanese population study H Yamamoto, M Suzuki, R Matsuta, K Sasaki, MI Kang, K Kami, Y Tatara, ... Metabolites 11 (5), 314, 2021 | 4 | 2021 |
NUCLEAR FACTOR KAPPA B PATHWAY INHIBITOR COMPOSITION AND USE OF SAME CJ Henrich, MI Kang, HR Bokesch, KR Gustafson, NH Colburn, ... US Patent US 8729053 B2, 2014 | | 2014 |
A laminar shear stress activates Keap 1-Nrf2 system in endothelial cells T HOSOYA, MI KANG, K ITOH, K UCHIDA, M YAMAMOTO Seikagaku 76 (8), 957, 2004 | | 2004 |