| MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition RC Coll, JR Hill, CJ Day, A Zamoshnikova, D Boucher, NL Massey, ... Nature chemical biology 15 (6), 556-559, 2019 | 802 | 2019 |
| Temporal profiling of the breast tumour microenvironment reveals collagen XII as a driver of metastasis M Papanicolaou, AL Parker, M Yam, EC Filipe, SZ Wu, JL Chitty, K Wyllie, ... Nature communications 13 (1), 4587, 2022 | 128 | 2022 |
| Charting the unexplored extracellular matrix in cancer EC Filipe, JL Chitty, TR Cox International journal of experimental pathology 99 (2), 58-76, 2018 | 111 | 2018 |
| A Genomic Safe Haven for Mutant Complementation in Cryptococcus neoformans SDM Arras, JL Chitty, KL Blake, BL Schulz, JA Fraser PloS one 10 (4), e0122916, 2015 | 105 | 2015 |
| Recent advances in understanding the complexities of metastasis JL Chitty, EC Filipe, MC Lucas, D Herrmann, TR Cox, P Timpson F1000Research 7, 2018 | 102 | 2018 |
| Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma determine response to SLC7A11 inhibition G Sharbeen, JA McCarroll, A Akerman, C Kopecky, J Youkhana, ... Cancer research 81 (13), 3461-3479, 2021 | 81 | 2021 |
| Targeting lysyl oxidase family meditated matrix cross-linking as an anti-stromal therapy in solid tumours YFI Setargew, K Wyllie, RD Grant, JL Chitty, TR Cox Cancers 13 (3), 491, 2021 | 79 | 2021 |
| A first-in-class pan-lysyl oxidase inhibitor impairs stromal remodeling and enhances gemcitabine response and survival in pancreatic cancer JL Chitty, M Yam, L Perryman, AL Parker, JN Skhinas, YFI Setargew, ... Nature Cancer 4 (9), 1326-1344, 2023 | 41 | 2023 |
| Purine acquisition and synthesis by human fungal pathogens JL Chitty, JA Fraser Microorganisms 5 (2), 33, 2017 | 37 | 2017 |
| Targeting the lysyl oxidases in tumour desmoplasia JL Chitty, YFI Setargew, TR Cox Biochemical Society Transactions 47 (6), 1661-1678, 2019 | 36 | 2019 |
| GMP synthase is required for virulence factor production and infection by Cryptococcus neoformans JL Chitty, TL Tatzenko, SJ Williams, YQAE Koh, EC Corfield, MS Butler, ... Journal of Biological Chemistry 292 (7), 3049-3059, 2017 | 25 | 2017 |
| Sirtuins in the phylum Basidiomycota: A role in virulence in Cryptococcus neoformans SDM Arras, JL Chitty, MSI Wizrah, PE Erpf, BL Schulz, M Tanurdzic, ... Scientific reports 7 (1), 46567, 2017 | 24 | 2017 |
| Disruption of de Novo Adenosine Triphosphate (ATP) Biosynthesis Abolishes Virulence in Cryptococcus neoformans RD Blundell, SJ Williams, SDM Arras, JL Chitty, KL Blake, DJ Ericsson, ... ACS infectious diseases 2 (9), 651-663, 2016 | 24 | 2016 |
| miRNAs in pancreatic cancer progression and metastasis ETY Mok, JL Chitty, TR Cox Clinical & Experimental Metastasis, 1-24, 2024 | 22 | 2024 |
| Antibacterial and antifungal screening of natural products sourced from Australian fungi and characterisation of pestalactams D–F KD Beattie, N Ellwood, R Kumar, X Yang, PC Healy, V Choomuenwai, ... Phytochemistry 124, 79-85, 2016 | 22 | 2016 |
| Cryptococcus neoformans ADS lyase is an enzyme essential for virulence whose crystal structure reveals features exploitable in antifungal drug design JL Chitty, KL Blake, RD Blundell, YQAE Koh, M Thompson, ... Journal of Biological Chemistry 292 (28), 11829-11839, 2017 | 16 | 2017 |
| The Mini‐Organo: A rapid high‐throughput 3D coculture organotypic assay for oncology screening and drug development JL Chitty, JN Skhinas, EC Filipe, S Wang, CR Cupello, RD Grant, M Yam, ... Cancer Reports 3 (1), e1209, 2020 | 12 | 2020 |
| Antimicrobial octapeptin C4 analogues active against Cryptococcus species JL Chitty, MS Butler, A Suboh, DJ Edwards, MA Cooper, JA Fraser, ... Antimicrobial agents and chemotherapy 62 (2), 10.1128/aac. 00986-17, 2018 | 11 | 2018 |
| Quantitation of Purines from Pigeon Guano and Implications for Cryptococcus neoformans Survival During Infection JL Chitty, DJ Edwards, AAB Robertson, MS Butler, JA Duley, MA Cooper, ... Mycopathologia 184, 273-281, 2019 | 9 | 2019 |
| Australian pancreatic cancer genome I (2021) Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma determine response to SLC7A11 inhibition G Sharbeen, JA McCarroll, A Akerman, C Kopecky, J Youkhana, ... Cancer Res 81 (13), 3461-3479, 0 | 9 | |